Search Results - "Vines, Douglass C."

Administration of Hypoxia-Activated Prodrug Evofosfamide after Conventional Adjuvant Therapy Enhances Therapeutic Outcome and Targets Cancer-Initiating Cells in Preclinical Models of Colorectal Cancer by Haynes, Jennifer, McKee, Trevor D, Haller, Andrew, Wang, Yadong, Leung, Cherry, Gendoo, Deena M A, Lima-Fernandes, Evelyne, Kreso, Antonija, Wolman, Robin, Szentgyorgyi, Eva, Vines, Douglass C, Haibe-Kains, Benjamin, Wouters, Bradly G, Metser, Ur, Jaffray, David A, Smith, Myles, O'Brien, Catherine A

“…Cancer-initiating cells (C-IC) have been described in multiple cancer types, including colorectal cancer. C-ICs are defined by their capacity to self-renew,…”
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Molecular Alterations in the Hippocampus after Experimental Subarachnoid Hemorrhage by Han, Sang Myung, Wan, Hoyee, Kudo, Gen, Foltz, Warren D, Vines, Douglass C, Green, David E, Zoerle, Tommaso, Tariq, Asma, Brathwaite, Shakira, D'Abbondanza, Josephine, Ai, Jinglu, Macdonald, R Loch

“…Patients with aneurysmal subarachnoid hemorrhage (SAH) frequently have deficits in learning and memory that may or may not be associated with detectable brain…”
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Widespread decrease of nicotinic acetylcholine receptors in Parkinson's disease by Fujita, Masahiro, Ichise, Masanori, Zoghbi, Sami S., Liow, Jeih-San, Ghose, Subroto, Vines, Douglass C., Sangare, Janet, Lu, Jian-Qiang, Cropley, Vanessa L., Iida, Hidehiro, Kim, Kyeong Min, Cohen, Robert M., Bara-Jimenez, William, Ravina, Bernard, Innis, Robert B.

“…Objective Nicotinic acetylcholine receptors have close interactions with the dopaminergic system and play critical roles in cognitive function. The purpose of…”
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Evaluation of anesthesia effects on [ 18F]FDG uptake in mouse brain and heart using small animal PET by Toyama, Hiroshi, Ichise, Masanori, Liow, Jeih-San, Vines, Douglass C., Seneca, Nicholas M., Modell, Kendra J., Seidel, Jurgen, Green, Michael V., Innis, Robert B.

“…This study evaluates effects of anesthesia on 18F-FDG (FDG) uptake in mouse brain and heart to establish the basic conditions of small animal PET imaging…”
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Predicting Radiation Esophagitis Using 18F-FDG PET During Chemoradiotherapy for Locally Advanced Non-Small Cell Lung Cancer by Mehmood, Qurrat, Sun, Alexander, Becker, Nathan, Higgins, Jane, Marshall, Andrea, Le, Lisa W, Vines, Douglass C, McCloskey, Paula, Ford, Victoria, Clarke, Katy, Yap, Mei, Bezjak, Andrea, Bissonnette, Jean-Pierre

“…Treatment of locally advanced non-small cell lung cancer with chemoradiotherapy (CRT) is limited by development of toxicity in normal tissue, including…”
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Correlation of Somatostatin Receptor-2 Expression with Gallium-68-DOTA-TATE Uptake in Neuroblastoma Xenograft Models by Vali, Reza, Shammas, Amer, Besanger, Travis, Baruchel, Sylvain, Wu, Bing, Do, Trevor, Ganguly, Milan, Komal, Teesha, McKee, Trevor, Scollard, Deborah A., Vines, Douglass C., Zhang, Libo, Alexander, Natasha

“…Peptide-receptor imaging and therapy with radiolabeled somatostatin analogs such as 68Ga-DOTA-TATE and 177Lu-DOTA-TATE have become an effective treatment…”
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Effects of Early Life Stress on [11C]DASB Positron Emission Tomography Imaging of Serotonin Transporters in Adolescent Peer- and Mother-Reared Rhesus Monkeys by Ichise, Masanori, Vines, Douglass C, Gura, Tami, Anderson, George M, Suomi, Stephen J, Higley, J. Dee, Innis, Robert B

“…Peer-reared (PR) rhesus monkeys with early maternal separation later exhibit aggressiveness, impaired impulse control, alcohol abuse, and low CSF…”
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Evaluation of mouse tail-vein injections both qualitatively and quantitatively on small-animal PET tail scans by Vines, Douglass C, Green, David E, Kudo, Gen, Keller, Harald

“…Quantitative small-animal PET of mice requires successful delivery of radiotracers into the venous system. Intravenous injection of radiotracers via lateral…”
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Quantification of Local Tumor Response to Fractionated Radiation Therapy for Non-Hodgkin Lymphoma Using Weekly 18F-FDG PET/CT Imaging by Keller, Harald, Goda, Jayant Sastri, Vines, Douglass C., Lockwood, Gina, Tsang, Richard

“…To quantify, in a feasibility study, metabolic and volumetric response to fractionated radiation therapy (RT) using weekly 18F fluoro-deoxyglucose positron…”
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PET imaging of brain with the beta-amyloid probe, [11C]6-OH-BTA-1, in a transgenic mouse model of Alzheimer's disease by Toyama, Hiroshi, Ye, Daniel, Ichise, Masanori, Liow, Jeih-San, Cai, Lisheng, Jacobowitz, David, Musachio, John L, Hong, Jinsoo, Crescenzo, Mathew, Tipre, Dnyanesh, Lu, Jian-Qiang, Zoghbi, Sami, Vines, Douglass C, Seidel, Jurgen, Katada, Kazuhiro, Green, Michael V, Pike, Victor W, Cohen, Robert M, Innis, Robert B

“…The purpose of this study was to evaluate the capacity of [11C]6-OH-BTA-1 and positron emission tomography (PET) to quantify beta-amyloid (Abeta) plaques in…”
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Positron-emission tomography imaging of the TSPO with [(18)F]FEPPA in a preclinical breast cancer model by Vasdev, Neil, Green, David E, Vines, Douglass C, McLarty, Kristin, McCormick, Patrick N, Moran, Matthew D, Houle, Sylvain, Wilson, Alan A, Reilly, Raymond M

“…The present study aims to image the 18-kDa translocator protein (TSPO; formerly known as the peripheral benzodiazepine receptor) in a preclinical human breast…”
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Synthesis and preliminary biological evaluations of [18F]-1-deoxy-1-fluoro-scyllo-inositol by Vasdev, Neil, Chio, Jason, van Oosten, Erik M, Nitz, Mark, McLaurin, Joanne, Vines, Douglass C, Houle, Sylvain, Reilly, Raymond M, Wilson, Alan A

“…A novel PET radiotracer, [18F]-1-deoxy-1-fluoro-scyllo-inositol, was synthesized via a one-pot reaction in 16 +/- 3% uncorrected radiochemical yield within 80…”
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Quantitative PET Comparing Gated with Nongated Acquisitions Using a NEMA Phantom with Respiratory-Simulated Motion by Vines, Douglass C, Keller, Harald, Hoisak, Jeremy D.P, Breen, Stephen L

“…This study evaluated the use of gated versus nongated PET acquisitions for absolute quantification of radioisotope concentration (RC) in a respiratory…”
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Evaluation of 2 Scatter Correction Methods Using a Striatal Phantom for Quantitative Brain SPECT by Vines, Douglass C, Ichise, Masanori, Liow, Jeih-San, Toyama, Hiroshi, Innis, Robert B

“…Scatter correction is an important factor in quantitative SPECT. In this study, we evaluated 2 methods of scatter correction for brain SPECT. The first is…”
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Evaluation of differential magnification during brain SPECT acquisition by Vines, DC, Ichise, M

“…We developed a modification of the acquisition zoom technique, referred to as differential magnification (DM), to improve the pixel resolution with fanbeam…”
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Measurement of Tumor Hypoxia in Patients with Advanced Pancreatic Cancer Based on 18 F-Fluoroazomyin Arabinoside Uptake by Metran-Nascente, Cristiane, Yeung, Ivan, Vines, Douglass C., Metser, Ur, Dhani, Neesha C., Green, David, Milosevic, Michael, Jaffray, David, Hedley, David W.

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Measurement of Tumor Hypoxia in Patients with Advanced Pancreatic Cancer Based on sigma up 18 Theta -Fluoroazomyin Arabinoside Uptake by Metran-Nascente, Cristiane, Yeung, Ivan, Vines, Douglass C, Metser, Ur, Dhani, Neesha C, Green, David, Milosevic, Michael, Jaffray, David, Hedley, David W

“…Pancreatic cancers are thought to be unusually hypoxic, which might sensitize them to drugs that are activated under hypoxic conditions. In order to develop…”
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Measurement of Tumor Hypoxia in Patients with Advanced Pancreatic Cancer Based on ^sup 18^F-Fluoroazomyin Arabinoside Uptake by Metran-Nascente, Cristiane, Yeung, Ivan, Vines, Douglass C, Metser, Ur, Dhani, Neesha C, Green, David, Milosevic, Michael, Jaffray, David, Hedley, David W

“…Pancreatic cancers are thought to be unusually hypoxic, which might sensitize them to drugs that are activated under hypoxic conditions. In order to develop…”
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External radioactive reference markers in SPECT imaging of the dopamine system by Vines, DC, Ivo, BD, Ballinger, JR, Ichise, M

“…External radioactive reference markers have been used to localize the canthomeatal (CM) line and correct for head rotation in perfusion brain SPECT. This…”
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[ 18F]FDG mouse brain PET imaging: absolute quantification of regional cerebral glucose utilization as compared with 2-[ 14C]DG autoradiography by Toyama, Hiroshi, Ichise, Masanori, Liow, Jeih-San, Modell, Kendra J, Vines, Douglass C, Zoghbi, Sami, Esaki, Takanori, Cook, Michelle, Seidel, Jurgen, Katada, Kazuhiro, Sokoloff, Louis, Green, Michael V, Innis, Robert B

“…The purpose of this study was to evaluate the feasibility of absolute quantification of regional cerebral glucose utilization (rCMR glc) in mice with 18FDG…”
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