Search Results - "Vineberg, Jacob G."

Drug discovery targeting cell division proteins, microtubules and FtsZ by Ojima, Iwao, Kumar, Kunal, Awasthi, Divya, Vineberg, Jacob G.

“…Eukaryotic cell division or cytokinesis has been a major target for anticancer drug discovery. After the huge success of paclitaxel and docetaxel,…”
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Design, Synthesis, and Biological Evaluation of Theranostic Vitamin–Linker–Taxoid Conjugates by Vineberg, Jacob G, Wang, Tao, Zuniga, Edison S, Ojima, Iwao

“…Novel tumor-targeting theranostic conjugates 1 and 2, bearing either a fluorine-labeled prosthetic as a potential 18F-PET radiotracer (1) or a fluorescence…”
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Design, Synthesis, and Biological Evaluations of Tumor-Targeting Dual-Warhead Conjugates for a Taxoid–Camptothecin Combination Chemotherapy by Vineberg, Jacob G, Zuniga, Edison S, Kamath, Anushree, Chen, Ying-Jen, Seitz, Joshua D, Ojima, Iwao

“…Novel tumor-targeting dual-warhead conjugates, 2 (DW-1) and 3 (DW-2), which consist of a next-generation taxoid, 1 (SB-T-1214), and camptothecin as two…”
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Design, synthesis and biological evaluation of a highly-potent and cancer cell selective folate–taxoid conjugate by Seitz, Joshua D., Vineberg, Jacob G., Herlihy, Evan, Park, Bora, Melief, Eduard, Ojima, Iwao

“…[Display omitted] The folate receptor (FR) has been widely recognized as an excellent target for the tumor-selective delivery of cytotoxic agents, and four…”
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Synthesis of a Next-Generation Taxoid by Rapid Methylation Amenable for 11 C-Labeling by Seitz, Joshua D, Wang, Tao, Vineberg, Jacob G, Honda, Tadashi, Ojima, Iwao

“…Next-generation taxoids, such as SB-T-1214, are highly potent cytotoxic agents that exhibit remarkable efficacy against drug-resistant tumors in vivo,…”
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Design and synthesis of tumor-targeting theranostic drug conjugates for SPECT and PET imaging studies by Wang, Tao, Vineberg, Jacob G., Honda, Tadashi, Ojima, Iwao

“…[Display omitted] •Design and synthesis of novel tumor-targeting drug conjugates with imaging arms.•Theranostic drug conjugate with a ligand for a 64Cu for PET…”
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Fluorine-containing taxoid anticancer agents and their tumor-targeted drug delivery by Seitz, Joshua, Vineberg, Jacob G., Zuniga, Edison S., Ojima, Iwao

“…This account presents our recent progress, in perspective, on the strategic incorporation of fluorine(s) for the development of taxoid-based tumor-targeted…”
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Design, synthesis and application of fluorine-labeled taxoids as 19F NMR probes for the metabolic stability assessment of tumor-targeted drug delivery systems by Seitz, Joshua D., Vineberg, Jacob G., Wei, Longfei, Khan, Jonathan F., Lichtenthal, Brendan, Lin, Chi-Feng, Ojima, Iwao

“…Novel biotin-linker-taxoid conjugates, BLT-F2 and BLT-S-F6, were synthesized with strategically incorporated fluorine substituents to observe disulfide linker…”
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Synthesis of a Next-Generation Taxoid by Rapid Methylation Amenable for 11C‑Labeling by Seitz, Joshua D, Wang, Tao, Vineberg, Jacob G, Honda, Tadashi, Ojima, Iwao

“…Next-generation taxoids, such as SB-T-1214, are highly potent cytotoxic agents that exhibit remarkable efficacy against drug-resistant tumors in vivo,…”
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Design, Synthesis and Application of Fluorine-Labeled Taxoids as 19 F NMR Probes for the Metabolic Stability Assessment of Tumor-Targeted Drug Delivery Systems by Seitz, Joshua D, Vineberg, Jacob G, Wei, Longfei, Khan, Jonathan F, Lichtenthal, Brendan, Lin, Chi-Feng, Ojima, Iwao

“…Novel tumor-targeting drug conjugates, BLT-F ( ) and BLT-S-F ( ), bearing a fluorotaxoid as the warhead, a mechanism-based self-immolative disulfide linker,…”
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Design, synthesis, and biological evaluation of novel taxoid-based drug conjugates and theranostic imaging agents towards tumor-targeted chemotherapy by Vineberg, Jacob G

“…Cancer remains the second leading cause of death in the United States, accounting for nearly a quarter of all deaths, and is exceeded only by heart disease…”
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Design, synthesis, and biological evaluation of novel taxoid-based drug conjugates and theranostic imaging agents towards tumor-targeted chemotherapy by Vineberg, Jacob G

“…Cancer remains the second leading cause of death in the United States, accounting for nearly a quarter of all deaths, and is exceeded only by heart disease…”
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