Search Results - "Vine, K L"

Cytotoxic and anticancer activities of isatin and its derivatives: a comprehensive review from 2000-2008 by Vine, K L, Matesic, L, Locke, J M, Ranson, M, Skropeta, D

“…Isatin (1H-indole-2,3-dione) and its derivatives demonstrate a diverse array of biological and pharmacological activities including anticonvulsant,…”
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Targeting urokinase and the transferrin receptor with novel, anti-mitotic N-alkylisatin cytotoxin conjugates causes selective cancer cell death and reduces tumor growth by Vine, K L, Indira Chandran, V, Locke, J M, Matesic, L, Lee, J, Skropeta, D, Bremner, J B, Ranson, M

“…Tumor-specific delivery of ligand-directed prodrugs can increase the therapeutic window of chemotherapeutics by maintaining efficacy whilst decreasing toxic…”
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Enhancing pancreatic cancer immunotherapy: Leveraging localized delivery strategies through the use of implantable devices and scaffolds by Minaei, E., Ranson, M., Aghmesheh, M., Sluyter, R., Vine, K.L.

“…Pancreatic cancer (PC) remains the predominant type of upper gastrointestinal tract cancer, associated with heightened morbidity and a survival rate below 12%…”
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SerpinB2 regulates stromal remodelling and local invasion in pancreatic cancer by Harris, N L E, Vennin, C, Conway, J R W, Vine, K L, Pinese, M, Cowley, M J, Shearer, R F, Lucas, M C, Herrmann, D, Allam, A H, Pajic, M, Morton, J P, Biankin, A V, Ranson, M, Timpson, P, Saunders, D N

“…Pancreatic cancer has a devastating prognosis, with an overall 5-year survival rate of ~8%, restricted treatment options and characteristic molecular…”
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Individual characteristics associated with community integration of adults with intellectual disability by Vine, Xanthe K. L., Hamilton, David I.

“…Background The purpose of this study was to identify individual characteristics associated with community integration of adults with an intellectual…”
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The antiangiogenic properties of sulfated β-cyclodextrins in anticancer formulations incorporating 5-fluorouracil by Watson, Clare A, Vine, Kara L, Locke, Julie M, Bezos, Anna, Parish, Christopher R, Ranson, Marie

“…Sulfated β-cyclodextrins (S-β-CDs) are useful excipients for improving the solubility of drugs. One such formulation incorporating 5-fluorouracil (5-FU),…”
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Preclinical evaluation of novel, all-in-one formulations of 5-fluorouracil and folinic acid with reduced toxicity profiles by Stutchbury, Tamantha K, Vine, Kara L, Locke, Julie M, Chrisp, Jeremy S, Bremner, John B, Clingan, Philip R, Ranson, Marie

“…5-Fluorouracil (5-FU) in combination with its synergistic biomodulator folinic acid maintains a pivotal position in cancer chemotherapy. However, clinical…”
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Development and assessment of novel all-in-one parenteral formulations with integrated anticoagulant properties for the concomitant delivery of 5-fluorouracil and calcium folinate by Locke, Julie M, Stutchbury, Tamantha K, Vine, Kara L, Gamble, Allan B, Clingan, Philip R, Bremner, John B, Ranson, Marie

“…5-Fluorouracil in combination with its biomodulator folinic acid maintains a pivotal position in current anticancer treatment regimens. However, limitations in…”
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PO-437 Drug and radio sensitivity profile of a primary CTC cell line derived from a patient with metastatic neuroendocrine tumour of the distal oesophagus by Minaei, E, Brungs, D, Engels, E, Vine, KL, Tehei, M, Corde, S, Ranson, M

“…IntroductionCirculating Tumour Cells (CTCs) are important biomarkers in many solid tumours including gastroesophageal cancer. Cultures derived from CTCs…”
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Individual characteristics associated with community integration of adults with intellectual disability by Vine, Xanthe K. L., Hamilton, David I.

“…Background The purpose of this study was to identify individual characteristics associated with community integration of adults with an intellectual…”
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