Search Results - "Vincetti, Paolo"

Discovery of Multitarget Antivirals Acting on Both the Dengue Virus NS5-NS3 Interaction and the Host Src/Fyn Kinases by Vincetti, Paolo, Caporuscio, Fabiana, Kaptein, Suzanne, Gioiello, Antimo, Mancino, Valentina, Suzuki, Youichi, Yamamoto, Naoki, Crespan, Emmanuele, Lossani, Andrea, Maga, Giovanni, Rastelli, Giulio, Castagnolo, Daniele, Neyts, Johan, Leyssen, Pieter, Costantino, Gabriele, Radi, Marco

“…This study describes the discovery of novel dengue virus inhibitors targeting both a crucial viral protein–protein interaction and an essential host cell…”
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Iterative synthesis of 1,3-polyboronic esters with high stereocontrol and application to the synthesis of bahamaolide A by Aiken, Sheenagh G., Bateman, Joseph M., Liao, Hsuan-Hung, Fawcett, Alexander, Bootwicha, Teerawut, Vincetti, Paolo, Myers, Eddie L., Noble, Adam, Aggarwal, Varinder K.

“…Polyketide natural products often contain common repeat motifs, for example, propionate, acetate and deoxypropionate, and so can be synthesized by iterative…”
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Identification of Breast Cancer Inhibitors Specific for G Protein‐Coupled Estrogen Receptor (GPER)‐Expressing Cells by Aiello, Francesca, Carullo, Gabriele, Giordano, Francesca, Spina, Elena, Nigro, Alessandra, Garofalo, Antonio, Tassini, Sabrina, Costantino, Gabriele, Vincetti, Paolo, Bruno, Agostino, Radi, Marco

“…Together with estrogen receptors ERα and ERβ, the G protein‐coupled estrogen receptor (GPER) mediates important pathophysiological signaling pathways induced…”
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Selective Inhibitors of G2019S-LRRK2 Kinase Activity by Garofalo, Albert W, Bright, Jessica, De Lombaert, Stéphane, Toda, Alyssa M. A, Zobel, Kerry, Andreotti, Daniele, Beato, Claudia, Bernardi, Silvia, Budassi, Federica, Caberlotto, Laura, Gao, Peng, Griffante, Cristiana, Liu, Xinying, Mengatto, Luisa, Migliore, Marco, Sabbatini, Fabio Maria, Sava, Anna, Serra, Elena, Vincetti, Paolo, Zhang, Mingliang, Carlisle, Holly J

“…Pathogenic variants in the leucine-rich repeat kinase 2 (LRRK2) gene have been identified that increase the risk for developing Parkinson’s disease in a…”
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Scaffold Morphing Approach To Expand the Toolbox of Broad-Spectrum Antivirals Blocking Dengue/Zika Replication by Vincetti, Paolo, Kaptein, Suzanne J. F, Costantino, Gabriele, Neyts, Johan, Radi, Marco

“…We have recently discovered a family of 2,6-diaminopurine derivatives acting as DENV inhibitors by targeting an allosteric pocket on the thumb of the viral NS5…”
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A microwave-assisted multicomponent protocol for the synthesis of benzofuran-2-carboxamides by Vincetti, Paolo, Brianza, Anna, Scalacci, Nicolò, Costantino, Gabriele, Castagnolo, Daniele, Radi, Marco

“…[Display omitted] •Microwave-assisted synthesis of highly functionalized benzofuran-2-carboxamides.•Compounds are obtained in a one-pot multicomponent reaction…”
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A one-pot two-step microwave-assisted synthesis of N1-substituted 5,6-ring-fused 2-pyridones by Radi, Marco, Vallerini, Gian Paolo, Petrelli, Alessia, Vincetti, Paolo, Costantino, Gabriele

“…A fast, versatile and practical one-pot, two-step microwave-assisted protocol for the direct synthesis of N1-substituted 5,6-ring-fused 2-pyridones has been…”
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Identification of Broad‐Spectrum Dengue/Zika Virus Replication Inhibitors by Functionalization of Quinoline and 2,6‐Diaminopurine Scaffolds by Kaptein, Suzanne J. F., Vincetti, Paolo, Crespan, Emmanuele, Rivera, Jorge I. Armijos, Costantino, Gabriele, Maga, Giovanni, Neyts, Johan, Radi, Marco

“…Social and demographic changes across the world over the past 50 years have resulted in significant outbreaks of arboviruses such as dengue virus (DENV) and…”
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Cover Feature: Identification of Broad‐Spectrum Dengue/Zika Virus Replication Inhibitors by Functionalization of Quinoline and 2,6‐Diaminopurine Scaffolds (ChemMedChem 14/2018) by Kaptein, Suzanne J. F., Vincetti, Paolo, Crespan, Emmanuele, Rivera, Jorge I. Armijos, Costantino, Gabriele, Maga, Giovanni, Neyts, Johan, Radi, Marco

“…The Cover Feature shows how a single purine derivative inhibits the replication of multiple mosquito‐borne flaviviruses by targeting a conserved allosteric…”
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Identification of Breast Cancer Inhibitors Specific for GProtein-Coupled Estrogen Receptor (GPER)-Expressing Cells by Aiello, Francesca, Carullo, Gabriele, Giordano, Francesca, Spina, Elena, Nigro, Alessandra, Garofalo, Antonio, Tassini, Sabrina, Costantino, Gabriele, Vincetti, Paolo, Bruno, Agostino, Radi, Marco

“…Together with estrogen receptors ER[alpha] and ER[beta], the Gprotein-coupled estrogen receptor (GPER) mediates important pathophysiological signaling pathways…”
Get full text