Search Results - "Vinceti, Alessandro"

Reduced gene templates for supervised analysis of scale-limited CRISPR-Cas9 fitness screens by Vinceti, Alessandro, Perron, Umberto, Trastulla, Lucia, Iorio, Francesco

“…Pooled genome-wide CRISPR-Cas9 screens are furthering our mechanistic understanding of human biology and have allowed us to identify new oncology therapeutic…”
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CoRe: a robustly benchmarked R package for identifying core-fitness genes in genome-wide pooled CRISPR-Cas9 screens by Vinceti, Alessandro, Karakoc, Emre, Pacini, Clare, Perron, Umberto, De Lucia, Riccardo Roberto, Garnett, Mathew J, Iorio, Francesco

“…CRISPR-Cas9 genome-wide screens are being increasingly performed, allowing systematic explorations of cancer dependencies at unprecedented accuracy and scale…”
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A benchmark of computational methods for correcting biases of established and unknown origin in CRISPR-Cas9 screening data by Vinceti, Alessandro, Iannuzzi, Raffaele M, Boyle, Isabella, Trastulla, Lucia, Campbell, Catarina D, Vazquez, Francisca, Dempster, Joshua M, Iorio, Francesco

“…CRISPR-Cas9 dropout screens are formidable tools for investigating biology with unprecedented precision and scale. However, biases in data lead to potential…”
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Author Correction: A benchmark of computational methods for correcting biases of established and unknown origin in CRISPR-Cas9 screening data by Vinceti, Alessandro, Iannuzzi, Rafaele M, Boyle, Isabella, Trastulla, Lucia, Campbell, Catarina D, Vazquez, Francisca, Dempster, Joshua M, Iorio, Francesco

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Minimal genome-wide human CRISPR-Cas9 library by Gonçalves, Emanuel, Thomas, Mark, Behan, Fiona M, Picco, Gabriele, Pacini, Clare, Allen, Felicity, Vinceti, Alessandro, Sharma, Mamta, Jackson, David A, Price, Stacey, Beaver, Charlotte M, Dovey, Oliver, Parry-Smith, David, Iorio, Francesco, Parts, Leopold, Yusa, Kosuke, Garnett, Mathew J

“…CRISPR guide RNA libraries have been iteratively improved to provide increasingly efficient reagents, although their large size is a barrier for many…”
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A heuristic algorithm solving the mutual-exclusivity-sorting problem by Vinceti, Alessandro, Trastulla, Lucia, Perron, Umberto, Raiconi, Andrea, Iorio, Francesco

“…Abstract Motivation Binary (or Boolean) matrices provide a common effective data representation adopted in several domains of computational biology, especially…”
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Phenotypic plasticity and genetic control in colorectal cancer evolution by Househam, Jacob, Heide, Timon, Cresswell, George D., Spiteri, Inmaculada, Kimberley, Chris, Zapata, Luis, Lynn, Claire, James, Chela, Mossner, Maximilian, Fernandez-Mateos, Javier, Vinceti, Alessandro, Baker, Ann-Marie, Gabbutt, Calum, Berner, Alison, Schmidt, Melissa, Chen, Bingjie, Lakatos, Eszter, Gunasri, Vinaya, Nichol, Daniel, Costa, Helena, Mitchinson, Miriam, Ramazzotti, Daniele, Werner, Benjamin, Iorio, Francesco, Jansen, Marnix, Caravagna, Giulio, Barnes, Chris P., Shibata, Darryl, Bridgewater, John, Rodriguez-Justo, Manuel, Magnani, Luca, Sottoriva, Andrea, Graham, Trevor A.

“…Genetic and epigenetic variation, together with transcriptional plasticity, contribute to intratumour heterogeneity 1 . The interplay of these biological…”
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An interactive web application for processing, correcting, and visualizing genome-wide pooled CRISPR-Cas9 screens by Vinceti, Alessandro, De Lucia, Riccardo Roberto, Cremaschi, Paolo, Perron, Umberto, Karakoc, Emre, Mauri, Luca, Fernandez, Carlos, Kluczynski, Krzysztof Henryk, Anderson, Daniel Stephen, Iorio, Francesco

“…A limitation of pooled CRISPR-Cas9 screens is the high false-positive rate in detecting essential genes arising from copy-number-amplified genomics regions. To…”
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