Search Results - "Vincenzo Belcastro"

Metabolic and endocrine effects of valproic acid chronic treatment by Belcastro, Vincenzo, D’Egidio, Claudia, Striano, Pasquale, Verrotti, Alberto

“…Summary Treatment of epileptic patients with valproic acid (VPA) may be associated with substantial weight changes that may increase morbidity and impair…”
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Discovery of drug mode of action and drug repositioning from transcriptional responses by Iorio, Francesco, Bosotti, Roberta, Scacheri, Emanuela, Belcastro, Vincenzo, Mithbaokar, Pratibha, Ferriero, Rosa, Murino, Loredana, Tagliaferri, Roberto, Brunetti-Pierri, Nicola, Isacchi, Antonella, Bernardo, Diego di, Cantor, Charles R.

“…A bottleneck in drug discovery is the identification of the molecular targets of a compound (mode of action, MoA) and of its off-target effects. Previous…”
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Interrogating the microbiome: experimental and computational considerations in support of study reproducibility by Poussin, Carine, Sierro, Nicolas, Boué, Stéphanie, Battey, James, Scotti, Elena, Belcastro, Vincenzo, Peitsch, Manuel C., Ivanov, Nikolai V., Hoeng, Julia

“…[Display omitted] •Growing evidence indicates that the microbiome plays an important role in health and disease.•Reliable and meaningful scientific conclusions…”
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Identification of microRNA-regulated gene networks by expression analysis of target genes by Gennarino, Vincenzo Alessandro, D'Angelo, Giovanni, Dharmalingam, Gopuraja, Fernandez, Serena, Russolillo, Giorgio, Sanges, Remo, Mutarelli, Margherita, Belcastro, Vincenzo, Ballabio, Andrea, Verde, Pasquale, Sardiello, Marco, Banfi, Sandro

“…MicroRNAs (miRNAs) and transcription factors control eukaryotic cell proliferation, differentiation, and metabolism through their specific gene regulatory…”
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Human bronchial epithelial cells exposed in vitro to cigarette smoke at the air-liquid interface resemble bronchial epithelium from human smokers by Mathis, Carole, Poussin, Carine, Weisensee, Dirk, Gebel, Stephan, Hengstermann, Arnd, Sewer, Alain, Belcastro, Vincenzo, Xiang, Yang, Ansari, Sam, Wagner, Sandra, Hoeng, Julia, Peitsch, Manuel C

“…Organotypic culture of human primary bronchial epithelial cells is a useful in vitro system to study normal biological processes and lung disease mechanisms,…”
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A Yeast Synthetic Network for In Vivo Assessment of Reverse-Engineering and Modeling Approaches by Cantone, Irene, Marucci, Lucia, Iorio, Francesco, Ricci, Maria Aurelia, Belcastro, Vincenzo, Bansal, Mukesh, Santini, Stefania, di Bernardo, Mario, di Bernardo, Diego, Cosma, Maria Pia

“…Systems biology approaches are extensively used to model and reverse engineer gene regulatory networks from experimental data. Conversely, synthetic biology…”
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Perampanel Confirms to Be Effective and Well-Tolerated as an Add-On Treatment in Patients With Brain Tumor-Related Epilepsy (PERADET Study) by Coppola, Antonietta, Zarabla, Alessia, Maialetti, Andrea, Villani, Veronica, Koudriavtseva, Tatiana, Russo, Emilio, Nozzolillo, Agostino, Sueri, Chiara, Belcastro, Vincenzo, Balestrini, Simona, Ferlazzo, Edoardo, Giannarelli, Diana, Bilo, Leonilda, Maschio, Marta

“…Background: Epilepsy is one of the most common symptoms of brain tumors. It is often drug resistant and generally worsen patients' quality of life (QoL). Brain…”
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Non-convulsive status epilepticus after ischemic stroke: a hospital-based stroke cohort study by Belcastro, Vincenzo, Vidale, Simone, Gorgone, Gaetano, Pisani, Laura Rosa, Sironi, Luigi, Arnaboldi, Marco, Pisani, Francesco

“…To evaluate in the setting of a stroke unit ward the usefulness of a prolonged (>6 h) video-EEG recording (PVEEG) in identifying non-convulsive status…”
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Levetiracetam in brain ischemia: Clinical implications in neuroprotection and prevention of post-stroke epilepsy by Belcastro, Vincenzo, Pierguidi, Laura, Tambasco, Nicola

“…Abstract Several new antiepileptic drugs (AEDs) have been introduced for clinical use recently. These new AEDs, like the classic AEDs, target multiple cellular…”
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Valproic Acid Metabolism and its Consequences on Sexual Functions by Verrotti, Alberto, Mencaroni, Elisabetta, Cofini, Marta, Castagnino, Miriam, Leo, Antonio, Russo, Emilio, Belcastro, Vincenzo

“…Valproic acid (VPA) is a broad spectrum antiepileptic drug (AED) that is generally regarded as a first-choice agent for most forms of idiopathic and…”
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Transcriptional gene network inference from a massive dataset elucidates transcriptome organization and gene function by Belcastro, Vincenzo, Siciliano, Velia, Gregoretti, Francesco, Mithbaokar, Pratibha, Dharmalingam, Gopuraja, Berlingieri, Stefania, Iorio, Francesco, Oliva, Gennaro, Polishchuck, Roman, Brunetti-Pierri, Nicola, di Bernardo, Diego

“…We collected a massive and heterogeneous dataset of 20 255 gene expression profiles (GEPs) from a variety of human samples and experimental conditions, as well…”
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Crowdsourced benchmarking of taxonomic metagenome profilers: lessons learned from the sbv IMPROVER Microbiomics challenge by Poussin, Carine, Khachatryan, Lusine, Sierro, Nicolas, Narsapuram, Vijay Kumar, Meyer, Fernando, Kaikala, Vinay, Chawla, Vandna, Muppirala, Usha, Kumar, Sunil, Belcastro, Vincenzo, Battey, James N. D, Scotti, Elena, Boué, Stéphanie, McHardy, Alice C, Peitsch, Manuel C, Ivanov, Nikolai V, Hoeng, Julia

“…Abstract Background Selection of optimal computational strategies for analyzing metagenomics data is a decisive step in determining the microbial composition…”
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Understanding the limits of animal models as predictors of human biology: lessons learned from the sbv IMPROVER Species Translation Challenge by Rhrissorrakrai, Kahn, Belcastro, Vincenzo, Bilal, Erhan, Norel, Raquel, Poussin, Carine, Mathis, Carole, Dulize, Rémi H J, Ivanov, Nikolai V, Alexopoulos, Leonidas, Rice, J Jeremy, Peitsch, Manuel C, Stolovitzky, Gustavo, Meyer, Pablo, Hoeng, Julia

“…Inferring how humans respond to external cues such as drugs, chemicals, viruses or hormones is an essential question in biomedicine. Very often, however, this…”
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Colocalization of coregulated genes: a steered molecular dynamics study of human chromosome 19 by Di Stefano, Marco, Rosa, Angelo, Belcastro, Vincenzo, di Bernardo, Diego, Micheletti, Cristian

“…The connection between chromatin nuclear organization and gene activity is vividly illustrated by the observation that transcriptional coregulation of certain…”
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Plasticity and repair in the post-ischemic brain by Di Filippo, Massimiliano, Tozzi, Alessandro, Costa, Cinzia, Belcastro, Vincenzo, Tantucci, Michela, Picconi, Barbara, Calabresi, Paolo

“…Stroke is the second commonest cause of death and the principal cause of adult disability in the world. In most cases ischemic injuries have been reported to…”
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The centrosomal OFD1 protein interacts with the translation machinery and regulates the synthesis of specific targets by Iaconis, Daniela, Monti, Maria, Renda, Mario, van Koppen, Arianne, Tammaro, Roberta, Chiaravalli, Marco, Cozzolino, Flora, Pignata, Paola, Crina, Claudia, Pucci, Piero, Boletta, Alessandra, Belcastro, Vincenzo, Giles, Rachel H., Surace, Enrico Maria, Gallo, Simone, Pende, Mario, Franco, Brunella

“…Protein synthesis is traditionally associated with specific cytoplasmic compartments. We now show that OFD1, a centrosomal/basal body protein, interacts with…”
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Ictal Epileptic Headache: When Terminology Is Not a Moot Question by Parisi, Pasquale, Paolino, Maria Chiara, Raucci, Umberto, Della Vecchia, Nicoletta, Belcastro, Vincenzo, Villa, Maria Pia, Striano, Pasquale

“…The relationship between headache and epilepsy is complex and despite the nature of this association is not yet clear. In the last few years, it has been…”
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Hyperhomocysteinemia in epileptic patients on new antiepileptic drugs by Belcastro, Vincenzo, Striano, Pasquale, Gorgone, Gaetano, Costa, Cinzia, Ciampa, Clotilde, Caccamo, Daniela, Pisani, Laura R., Oteri, Giancarla, Marciani, Maria G., Aguglia, Umberto, Striano, Salvatore, Ientile, Riccardo, Calabresi, Paolo, Pisani, Francesco

“…Summary Purpose:  Older enzyme‐inducing antiepileptic drugs (AEDs) may induce supraphysiologic plasma concentrations of total (t) homocysteine (Hcy). The aim…”
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A parallel implementation of the network identification by multiple regression (NIR) algorithm to reverse-engineer regulatory gene networks by Gregoretti, Francesco, Belcastro, Vincenzo, di Bernardo, Diego, Oliva, Gennaro

“…The reverse engineering of gene regulatory networks using gene expression profile data has become crucial to gain novel biological knowledge. Large amounts of…”
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Myoclonus: Differential diagnosis and current management by Riva, Antonella, D'Onofrio, Gianluca, Ferlazzo, Edoardo, Pascarella, Angelo, Pasini, Elena, Franceschetti, Silvana, Panzica, Ferruccio, Canafoglia, Laura, Vignoli, Aglaia, Coppola, Antonietta, Badioni, Valeria, Beccaria, Francesca, Labate, Angelo, Gambardella, Antonio, Romeo, Antonino, Capovilla, Giuseppe, Michelucci, Roberto, Striano, Pasquale, Belcastro, Vincenzo

“…Myoclonus classically presents as a brief (10–50 ms duration), non‐rhythmic jerk movement. The etiology could vary considerably ranging from self‐limited to…”
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