Search Results - "Vincent, Mélanie"

Variability of Care in Infants with Severe Bronchiolitis: Less-Invasive Respiratory Management Leads to Similar Outcomes by Essouri, Sandrine, MD, PhD, Baudin, Florent, MD, Chevret, Laurent, MD, Vincent, Mélanie, MD, Emeriaud, Guillaume, MD, PhD, Jouvet, Philippe, MD, PhD

“…Objective To compare the management of children with severe bronchiolitis requiring intensive care (based on duration of ventilatory support and duration of…”
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Outpatient management of moderate cellulitis in children using high-dose oral cephalexin by Trottier, Evelyne D, Farley St-Amand, Beatrice, Vincent, Mélanie, Chevalier, Isabelle, Autmizguine, Julie, Tremblay, Stéphanie, Gouin, Serge

“…Abstract Objectives To evaluate the effectiveness of a high-dose (HD) oral cephalexin treatment guideline for children with moderate cellulitis treated as…”
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Glucocorticoid receptor deletion from the dorsal raphé nucleus of mice reduces dysphoria-like behavior and impairs hypothalamic-pituitary-adrenocortical axis feedback inhibition by Vincent, Melanie Y., Jacobson, Lauren

“…Glucocorticoids can cause depression and anxiety. Mechanisms for glucocorticoid effects on mood are largely undefined. The dorsal raphé nucleus (DRN) produces…”
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SIX1 and EWS/FLI1 co-regulate an anti-metastatic gene network in Ewing Sarcoma by Hughes, Connor J., Fields, Kaiah M., Danis, Etienne P., Hsu, Jessica Y., Neelakantan, Deepika, Vincent, Melanie Y., Gustafson, Annika L., Oliphant, Michael J., Sreekanth, Varsha, Zaberezhnyy, Vadym, Costello, James C., Jedlicka, Paul, Ford, Heide L.

“…Ewing sarcoma (ES), which is characterized by the presence of oncogenic fusion proteins such as EWS/FLI1, is an aggressive pediatric malignancy with a high…”
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SIX2 Mediates Late-Stage Metastasis via Direct Regulation of SOX2 and Induction of a Cancer Stem Cell Program by Oliphant, Michael U J, Vincent, Melanie Y, Galbraith, Matthew D, Pandey, Ahwan, Zaberezhnyy, Vadym, Rudra, Pratyaydipta, Johnson, Katherine R, Costello, James C, Ghosh, Debashis, DeGregori, James, Espinosa, Joaquin M, Ford, Heide L

“…The capacity for tumor cells to metastasize efficiently is directly linked to their ability to colonize secondary sites. Here we identify Six2, a developmental…”
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Eya3 promotes breast tumor-associated immune suppression via threonine phosphatase-mediated PD-L1 upregulation by Vartuli, Rebecca L, Zhou, Hengbo, Zhang, Lingdi, Powers, Rani K, Klarquist, Jared, Rudra, Pratyaydipta, Vincent, Melanie Y, Ghosh, Debashis, Costello, James C, Kedl, Ross M, Slansky, Jill E, Zhao, Rui, Ford, Heide L

“…Eya proteins are critical developmental regulators that are highly expressed in embryogenesis but downregulated after development. Amplification and/or…”
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Structural and Functional Analyses of an Allosteric EYA2 Phosphatase Inhibitor That Has On-Target Effects in Human Lung Cancer Cells by Anantharajan, Jothi, Zhou, Hengbo, Zhang, Lingdi, Hotz, Taylor, Vincent, Melanie Y, Blevins, Melanie A, Jansson, Anna E, Kuan, John Wee Liang, Ng, Elizabeth Yihui, Yeo, Yee Khoon, Baburajendran, Nithya, Lin, Grace, Hung, Alvin W, Joy, Joma, Patnaik, Samarjit, Marugan, Juan, Rudra, Pratyaydipta, Ghosh, Debashis, Hill, Jeffrey, Keller, Thomas H, Zhao, Rui, Ford, Heide L, Kang, CongBao

“…EYA proteins (EYA1-4) are critical developmental transcriptional cofactors that contain an EYA domain (ED) harboring Tyr phosphatase activity. EYA proteins are…”
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Dorsal raphé nucleus glucocorticoid receptors inhibit tph2 gene expression in male C57BL/6J mice by Vincent, Melanie Y., Donner, Nina C., Smith, David G., Lowry, Christopher A., Jacobson, Lauren

“…•Dorsal raphé glucocorticoid receptors inhibit DRN tryptophan hydroxylase 2 mRNA.•DRN GR deletion did not change basal serotonin or 5-HIAA content of DRN…”
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EYA2 tyrosine phosphatase inhibition reduces MYC and prevents medulloblastoma progression by Wolin, Arthur R, Vincent, Melanie Y, Hotz, Taylor, Purdy, Stephen C, Rosenbaum, Sheera R, Hughes, Connor J, Hsu, Jessica Y, Oliphant, Michael U J, Armstrong, Brock, Wessells, Veronica, Varella-Garcia, Marileila, Galbraith, Matthew D, Pierce, Angela, Wang, Dong, Venkataraman, Sujatha, Danis, Etienne, Veo, Bethany, Serkova, Natalie, Espinosa, Joaquin M, Gustafson, Daniel L, Vibhakar, Rajeev, Ford, Heide L

“…Abstract Background Medulloblastoma is the most common pediatric brain malignancy. Patients with the Group 3 subtype of medulloblastoma (MB) often exhibit MYC…”
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First-in-human phase I dose escalation trial of the first-in-class tumor microenvironment modulator VT1021 in advanced solid tumors by Mahalingam, Devalingam, Harb, Wael, Patnaik, Amita, Bullock, Andrea, Watnick, Randolph S., Vincent, Melanie Y., Chen, Jian Jenny, Wang, Suming, Pestana, Harold, Chao, Judy, Mahoney, James, Cieslewicz, Michael, Watnick, Jing

“…Background VT1021 is a cyclic peptide that induces the expression of thrombospondin-1 (TSP-1) in myeloid-derived suppressor cells (MDSCs) recruited to the…”
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Phase 1 dose expansion and biomarker study assessing first-in-class tumor microenvironment modulator VT1021 in patients with advanced solid tumors by Chen, Jian Jenny, Vincent, Melanie Y., Shepard, Dale, Peereboom, David, Mahalingam, Devalingam, Battiste, James, Patel, Manish R., Juric, Dejan, Wen, Patrick Y., Bullock, Andrea, Selfridge, Jennifer Eva, Pant, Shubham, Liu, Joyce, Li, Wendy, Fyfe, Susanne, Wang, Suming, Zota, Victor, Mahoney, James, Watnick, Randolph S., Cieslewicz, Michael, Watnick, Jing

“…Background Preclinical studies have demonstrated that VT1021, a first-in-class therapeutic agent, inhibits tumor growth via stimulation of thrombospondin-1…”
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Sensitivity of depression-like behavior to glucocorticoids and antidepressants is independent of forebrain glucocorticoid receptors by Vincent, Melanie Y, Hussain, Rifat J, Zampi, Michael E, Sheeran, Katherine, Solomon, Matia B, Herman, James P, Khan, Anum, Jacobson, Lauren

“…Abstract The location of glucocorticoid receptors (GR) implicated in depression symptoms and antidepressant action remains unclear. Forebrain glucocorticoid…”
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A simple method for measuring intracellular activities of glutamine synthetase and glutaminase in glial cells by Mongin, Alexander A, Hyzinski-García, María C, Vincent, Melanie Y, Keller, Jr, Richard W

“…Here we report and validate a simple method for measuring intracellular activities of glial glutamine synthetase (GS) and glutaminase (GLNase) in intact glial…”
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Effects of 18-methoxycoronaridine on ghrelin-induced increases in sucrose intake and accumbal dopamine overflow in female rats by McCallum, Sarah E., Taraschenko, Olga D., Hathaway, Ethan R., Vincent, Melanie Y., Glick, Stanley D.

“…Rationale 18-Methoxycoronaridine (18-MC), a selective antagonist of α3β4 nicotinic receptors, has been previously shown, in rats, to reduce the…”
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Hypo‐osmotic swelling modifies glutamate‐glutamine cycle in the cerebral cortex and in astrocyte cultures by Hyzinski‐García, María C., Vincent, Melanie Y., Haskew‐Layton, Renée E., Dohare, Preeti, Keller, Jr, Richard W., Mongin, Alexander A.

“…J. Neurochem. (2011) 10.1111/j.1471‐4159.2011.07289.x In our previous work, we found that perfusion of the rat cerebral cortex with hypo‐osmotic medium…”
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369 Clinical update of VT1021, a first-in-class CD36 and CD47 targeting immunomodulating agent, in subjects with pancreatic cancer and other solid tumors stratified by novel biomarkers by Mahalingam, Devalingam, Mulcahy, Mary, Juric, Dejan, Patel, Manish, Pant, Shubham, Ulahannan, Susanna, Dowlati, Afshin, Bullock, Andrea, Vaickus, Lou, Fyfe, Susanne, Vincent, Melanie, Wang, Suming, Chen, Jian, Crochiere, Marsha, Watnick, Randolph, Cieslewicz, Michael, Watnick, Jing

“…BackgroundOne barrier to treating pancreatic cancer is the immunosuppressive tumor microenvironment (TME). VT1021 is a cyclic peptide derived from prosaposin…”
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374 A first-in-human Phase 1/2 open label trial evaluating the safety, pharmacology, and preliminary efficacy of VT1021 in subjects with advanced solid tumors by Mahalingam, Devalingam, Harb, Wael, Patnaik, Amita, Ulahannan, Susanna, Mahdi, Haider, Ahluwalia, Manmeet, Patel, Manish, Dowlati, Afshin, Bullock, Andrea, Wen, Patrick, Pant, Shubham, Mulcahy, Mary, Guttendorf, Robert, Vaickus, Lou, Wang, Suming, Crochiere, Marsha, Vincent, Melanie, Cieslewicz, Michael, Watnick, Jing

“…BackgroundVT1021, a cyclic pentapeptide, reprograms myeloid-derived suppressor cells (MDSCs) and induces the production of thrombospondin-1 (Tsp-1) in the…”
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Evaluation of an anti-tumor necrosis factor therapeutic in a mouse model of Niemann-Pick C liver disease by Vincent, Melanie, Sayre, Naomi L, Graham, Mark J, Crooke, Rosanne M, Shealy, David J, Liscum, Laura

“…Niemann-Pick type C (NPC) disease is a lysosomal storage disease characterized by the accumulation of cholesterol and glycosphingolipids. The majority of NPC…”
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Very low birth weight newborns do not need repeat screening for congenital hypothyroidism by Vincent, Melanie A., Rodd, Celia, Dussault, Jean H., Van Vliet, Guy

“…Objective: To determine whether repeat screening for congenital hypothyroidism is necessary in newborns weighing <1500 g (very low birth weight [VLBW]). Study…”
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Nurse and dietitian: effective collaboration in rehabilitation by Poindessous, Jean-Luc, Basta, Martial, Renaud, Adeline, Vincent, Mélanie, Héron, Anne

“…In functional rehabilitation service, the dietician, as educator, contributes to preventing recidivism and return to independence. A hospital team demonstrates…”
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