Search Results - "Vincent, Karen J"

Current strategies in antibody engineering: Fc engineering and pH-dependent antigen binding, bispecific antibodies and antibody drug conjugates by Vincent, Karen J., Zurini, Mauro

“…Antibody engineering technologies are constantly advancing to improve the clinical effectiveness of monoclonal antibodies (mAbs). Effector functions may be…”
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Inhibition of tumorigenesis driven by different Wnt proteins requires blockade of distinct ligand-binding regions by LRP6 antibodies by Ettenberg, Seth A., Charlat, Olga, Daley, Michael P., Liu, Shanming, Vincent, Karen J., Stuart, Darrin D., Schuller, Alwin G., Yuan, Jing, Ospina, Beatriz, Green, John, Yu, Qunyan, Walsh, Renee, Li, Sharon, Schmitz, Rita, Heine, Holger, Bilic, Sanela, Ostrom, Lance, Mosher, Rebecca, Hartlepp, K. Felix, Zhu, Zhenping, Fawell, Stephen, Yao, Yung-Mae, Stover, David, Finan, Peter M., Porter, Jeffery A., Sellers, William R., Klagge, Ingo M., Cong, Feng, Nusse, Roeland

“…Disregulated Wnt/β-catenin signaling has been linked to various human diseases, including cancers. Inhibitors of oncogenic Wnt signaling are likely to have a…”
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Production of soluble mammalian proteins in Escherichia coli: identification of protein features that correlate with successful expression by Dyson, Michael R, Shadbolt, S Paul, Vincent, Karen J, Perera, Rajika L, McCafferty, John

“…In the search for generic expression strategies for mammalian protein families several bacterial expression vectors were examined for their ability to promote…”
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A simple vector system to improve performance and utilisation of recombinant antibodies by Martin, Cecile D, Rojas, Gertrudis, Mitchell, Joanne N, Vincent, Karen J, Wu, Jiahua, McCafferty, John, Schofield, Darren J

“…Isolation of recombinant antibody fragments from antibody libraries is well established using technologies such as phage display. Phage display vectors are…”
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Application of phage display to high throughput antibody generation and characterization by Schofield, Darren J, Pope, Anthony R, Clementel, Veronica, Buckell, Jenny, Chapple, Susan Dj, Clarke, Kay F, Conquer, Jennie S, Crofts, Anna M, Crowther, Sandra R E, Dyson, Michael R, Flack, Gillian, Griffin, Gareth J, Hooks, Yvette, Howat, William J, Kolb-Kokocinski, Anja, Kunze, Susan, Martin, Cecile D, Maslen, Gareth L, Mitchell, Joanne N, O'Sullivan, Maureen, Perera, Rajika L, Roake, Wendy, Shadbolt, S Paul, Vincent, Karen J, Warford, Anthony, Wilson, Wendy E, Xie, Jane, Young, Joyce L, McCafferty, John

“…We have created a high quality phage display library containing over 1010 human antibodies and describe its use in the generation of antibodies on an…”
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Retinoic acid receptor β2 and neurite outgrowth in the adult mouse spinal cord in vitro by Corcoran, Jonathan, So, Po-Lin, Barber, Robert D., Vincent, Karen J., Mazarakis, Nicholas D., Mitrophanous, Kyriacos A., Kingsman, Susan M., Maden, Malcolm

“…Retinoic acid, acting through the nuclear retinoic acid receptor β2(RARβ2), stimulates neurite outgrowth from peripheral nervous system tissue that has the…”
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JunD Regulates Transcription of the Tissue Inhibitor of Metalloproteinases-1 and Interleukin-6 Genes in Activated Hepatic Stellate Cells by Smart, David E., Vincent, Karen J., Arthur, Michael J.P., Eickelberg, Oliver, Castellazzi, Marc, Mann, Jelena, Mann, Derek A.

“…Activation of hepatic stellate cells (HSCs) to a myofibroblast-like phenotype is the pivotal event in hepatic wound healing and fibrosis. Rat HSCs activated in…”
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Control of the tissue inhibitor of metalloproteinases‐1 promoter in culture‐activated rat hepatic stellate cells: Regulation by activator protein‐1 DNA binding proteins by Bahr, Matthias J., Vincent, Karen J., Arthur, Michael J. P., Fowler, Andrew V., Smart, David E., Wright, Matthew C., Clark, Ian M., Benyon, R. Christopher, Iredale, John P., Mann, Derek A.

“…In the injured liver hepatic stellate cells (HSCs) undergo a dramatic phenotypic transformation known as “activation” in which they become myofibroblast‐like…”
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Retinoic acid receptor beta2 and neurite outgrowth in the adult mouse spinal cord in vitro by Corcoran, Jonathan, So, Po-Lin, Barber, Robert D, Vincent, Karen J, Mazarakis, Nicholas D, Mitrophanous, Kyriacos A, Kingsman, Susan M, Maden, Malcolm

“…Retinoic acid, acting through the nuclear retinoic acid receptor beta2 (RARbeta2), stimulates neurite outgrowth from peripheral nervous system tissue that has…”
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junD regulates transcription of the tissue inhbitor of metalloproteinases-1 and interleukin-6 genes in activated hepatic stellate cells by Smart, David E., Vincent, Karen J., Arthur, Michael Jp, Eickelberg, Oliver, Castellazzi, Marc, Mann, Jelena, Mann, Derek A.

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