Search Results - "Vincent, Karen A"

Innate Immunity and Angiogenesis by Frantz, Stefan, Vincent, Karen A, Feron, Olivier, Kelly, Ralph A

“…Activation of an innate immune response is among the first lines of defense after tissue injury. Restoring blood flow to the site of injured tissue is often a…”
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Hypoxia-Inducible Factor-1 Mediates Activation of Cultured Vascular Endothelial Cells by Inducing Multiple Angiogenic Factors by Yamakawa, Midori, Liu, Louis X, Date, Taro, Belanger, Adam J, Vincent, Karen A, Akita, Geoffrey Y, Kuriyama, Takayuki, Cheng, Seng H, Gregory, Richard J, Jiang, Canwen

“…ABSTRACT—Hypoxia-inducible factor-1 (HIF-1) mediates transcriptional activation of vascular endothelial growth factor (VEGF) and other hypoxia-responsive…”
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Stabilization of Vascular Endothelial Growth Factor mRNA by Hypoxia-Inducible Factor 1 by Liu, Louis X., Lu, Hsienwie, Luo, Yuxia, Date, Taro, Belanger, Adam J., Vincent, Karen A., Akita, Geoffrey Y., Goldberg, Mark, Cheng, Seng H., Gregory, Richard J., Jiang, Canwen

“…Hypoxia regulates expression of vascular endothelial growth factor (VEGF) by increasing its transcription and by stabilizing its mRNA. Despite the pivotal role…”
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Reversal of Integration and DNA Splicing Mediated by Integrase of Human Immunodeficiency Virus by Chow, Samson A., Vincent, Karen A., Ellison, Viola, Brown, Patrick O.

“…In retroviral integration, the viral integration protein (integrase) mediates a concerted DNA cleavage-ligation reaction in which the target DNA is cleaved and…”
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Hypoxia-inducible factor 1 mediates hypoxia-induced cardiomyocyte lipid accumulation by reducing the DNA binding activity of peroxisome proliferator-activated receptor α/retinoid X receptor by Belanger, Adam J., Luo, Zhengyu, Vincent, Karen A., Akita, Geoffrey Y., Cheng, Seng H., Gregory, Richard J., Jiang, Canwen

“…In response to cellular hypoxia, cardiomyocytes adapt to consume less oxygen by shifting ATP production from mitochondrial fatty acid β-oxidation to…”
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Angiogenesis is induced in a rabbit model of hindlimb ischemia by naked DNA encoding an HIF-1α/VP16 hybrid transcription factor by VINCENT, Karen A, SHYU, Kou-Gi, LUO, Yuxia, MAGNER, Meredith, TIO, Rene A, CANWEN JIANG, GOLDBERG, Mark A, AKITA, Geoffrey Y, GREGORY, Richard J, ISNER, Jeffrey M

“…Background —Hypoxia-inducible factor-1 (HIF-1) is a heterodimeric transcription factor that regulates expression of genes involved in O 2 homeostasis,…”
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AAVS1-Targeted Plasmid Integration in AAV Producer Cell Lines by Luo, Yuxia, Frederick, Amy, Martin, John M, Scaria, Abraham, Cheng, Seng H, Armentano, Donna, Wadsworth, Samuel C, Vincent, Karen A

“…Adeno-associated virus (AAV) producer cell lines are created via transfection of HeLaS3 cells with a single plasmid containing three components (the vector…”
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Characteristics of Minimally Oversized Adeno-Associated Virus Vectors Encoding Human Factor VIII Generated Using Producer Cell Lines and Triple Transfection by Nambiar, Bindu, Cornell Sookdeo, Cathleen, Berthelette, Patricia, Jackson, Robert, Piraino, Susan, Burnham, Brenda, Nass, Shelley, Souza, David, O'Riordan, Catherine R, Vincent, Karen A, Cheng, Seng H, Armentano, Donna, Kyostio-Moore, Sirkka

“…Several ongoing clinical studies are evaluating recombinant adeno-associated virus (rAAV) vectors as gene delivery vehicles for a variety of diseases. However,…”
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A hypoxic inducible factor-1α hybrid enhances collateral development and reduces vascular leakage in diabetic rats by Kajiwara, Hidetoshi, Luo, Zhengyu, Belanger, Adam J., Urabe, Akihiro, Vincent, Karen A., Akita, Geoffrey Y., Cheng, Seng H., Mochizuki, Seibu, Gregory, Richard J., Jiang, Canwen

“…Background Diabetes mellitus is a common comorbidity of atherosclerosis. Hypoxia‐inducible factor‐1 (HIF‐1) is the master regulator of the angiogenic response…”
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Harnessing the Response to Tissue Hypoxia: HIF-1α and Therapeutic Angiogenesis by Vincent, Karen A, Feron, Olivier, Kelly, Ralph A

“…In most cell types a family of transcriptional regulatory proteins termed hypoxia-inducible factors, of which HIF-1 is the most prevalent, mediates the…”
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Adenovirus-mediated expression of β-adrenergic receptor kinase C-terminus reduces intimal hyperplasia and luminal stenosis of arteriovenous polytetrafluoroethylene grafts in pigs by ZHENGYU LUO, AKITA, Geoffrey Y, DATE, Taro, TRELEAVEN, Christopher, VINCENT, Karen A, WOODCOCK, Denise, CHENG, Seng H, GREGORY, Richard J, CANWEN JIANG

“…Hemodialysis vascular access dysfunction is the single most important cause of morbidity in kidney hemodialysis patients. Failure of an arteriovenous…”
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An Essential Interaction between Distinct Domains of HIV-1 Integrase Mediates Assembly of the Active Multimer (∗) by Ellison, Viola, Gerton, Jennifer, Vincent, Karen A., Brown, Patrick O.

“…Integrase mediates integration of the retroviral genome into a host cell chromosome, an essential step in the viral life cycle. In vitro, a stable complex…”
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Differential effects of membrane and soluble Fas ligand on cardiomyocytes: role in ischemia/reperfusion injury by Date, Taro, Mochizuki, Seibu, Belanger, Adam J., Yamakawa, Midori, Luo, Zhengyu, Vincent, Karen A., Cheng, Seng H., Gregory, Richard J., Jiang, Canwen

“…Cardiomyocyte apoptosis by Fas ligand (FasL)/Fas signaling is associated with various pathophysiological conditions, such as ischemia/reperfusion injury and…”
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Effect of intron A from human cytomegalovirus (Towne) immediate-early gene on heterologous expression in mammalian cells by Chapman, B S, Thayer, R M, Vincent, K A, Haigwood, N L

“…A 2.4 kb fragment of hCMV (Towne strain), containing the 5' end of the major immediate-early gene, has been cloned, sequenced, and used to construct a series…”
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Gene expression profiles in human cardiac cells subjected to hypoxia or expressing a hybrid form of HIF-1 alpha by Jiang, Canwen, Lu, Hsienwie, Vincent, Karen A, Shankara, Srinivas, Belanger, Adam J, Cheng, Seng H, Akita, Geoffrey Y, Kelly, Ralph A, Goldberg, Mark A, Gregory, Richard J

“…The cellular response to hypoxia depends on rapid posttranslational modifications of proteins as well as regulation of gene expression. We performed serial…”
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Scaleable chromatographic purification process for recombinant adeno-associated virus (rAAV) by O'Riordan, Catherine R., Lachapelle, Amy L., Vincent, Karen A., Wadsworth, Samuel C.

“…Background Adeno‐associated virus (AAV) is a human parvovirus currently being developed as a vector for gene therapy applications. Traditionally AAV has been…”
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Enhancement of Fas ligand-induced inhibition of neointimal formation in rabbit femoral and iliac arteries by coexpression of p35 by Luo, Z, Garron, T, Palasis, M, Lu, H, Belanger, A J, Scaria, A, Vincent, K A, Date, T, Akita, G Y, Cheng, S H, Barry, J, Gregory, R J, Jiang, C

“…Adenovirus-mediated gene transfer of Fas ligand (FasL) inhibits neointimal formation in balloon-injured rat carotid arteries. Vascular smooth muscle (VSM)…”
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Catheter-mediated delivery of adenoviral vectors expressing β-adrenergic receptor kinase C-terminus inhibits intimal hyperplasia and luminal stenosis in rabbit iliac arteries by Luo, Zhengyu, Palasis, Maria, Yamakawa, Midori, Liu, Louis X., Vincent, Karen A., Trudell, Leonard, Akita, Geoffrey A., Koch, Walter J., Cheng, Seng H., Gregory, Richard J., Jiang, Canwen

“…Background Previous studies have shown that incubation of balloon‐injured rat carotid arteries with adenoviral vectors encoding the carboxyl terminus of the…”
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Hypoxia Up-regulates Expression of Peroxisome Proliferator-activated Receptor γ Angiopoietin-related Gene (PGAR) in Cardiomyocytes: Role of Hypoxia Inducible Factor 1α by Belanger, Adam J., Lu, Hsienwie, Date, Taro, Liu, Louis X., Vincent, Karen A., Akita, Geoffery Y., Cheng, Seng H., Gregory, Richard J., Jiang, Canwen

“…A. J. Belanger, H. Lu, T. Date, L. X. Liu, K. A. Vincent, G. Y. Akita, S. H. Cheng, R. J. Gregory and C. Jiang. Hypoxia Up-regulates Expression of Peroxisome…”
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Hypoxia-inducible factor 1 mediates hypoxia-induced cardiomyocyte lipid accumulation by reducing the DNA binding activity of peroxisome proliferator-activated receptor {alpha}/retinoid X receptor by Belanger, Adam J., Luo Zhengyu, Vincent, Karen A., Akita, Geoffrey Y., Cheng, Seng H., Gregory, Richard J., Jiang Canwen

“…In response to cellular hypoxia, cardiomyocytes adapt to consume less oxygen by shifting ATP production from mitochondrial fatty acid {beta}-oxidation to…”
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