Search Results - "Vincent, Isabel M"

The trypanocidal benzoxaborole AN7973 inhibits trypanosome mRNA processing by Begolo, Daniela, Vincent, Isabel M, Giordani, Federica, Pöhner, Ina, Witty, Michael J, Rowan, Timothy G, Bengaly, Zakaria, Gillingwater, Kirsten, Freund, Yvonne, Wade, Rebecca C, Barrett, Michael P, Clayton, Christine

“…Kinetoplastid parasites-trypanosomes and leishmanias-infect millions of humans and cause economically devastating diseases of livestock, and the few existing…”
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Transcriptional differentiation of Trypanosoma brucei during in vitro acquisition of resistance to acoziborole by Steketee, Pieter C, Giordani, Federica, Vincent, Isabel M, Crouch, Kathryn, Achcar, Fiona, Dickens, Nicholas J, Morrison, Liam J, MacLeod, Annette, Barrett, Michael P

“…Subspecies of the protozoan parasite Trypanosoma brucei are the causative agents of Human African Trypanosomiasis (HAT), a debilitating neglected tropical…”
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A molecular mechanism for eflornithine resistance in African trypanosomes by Vincent, Isabel M, Creek, Darren, Watson, David G, Kamleh, Mohammed A, Woods, Debra J, Wong, Pui Ee, Burchmore, Richard J S, Barrett, Michael P

“…Human African trypanosomiasis, endemic to sub-Saharan Africa, is invariably fatal if untreated. Its causative agent is the protozoan parasite Trypanosoma…”
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Metabolomic profiling of macrophages determines the discrete metabolomic signature and metabolomic interactome triggered by polarising immune stimuli by Rattigan, Kevin M, Pountain, Andrew W, Regnault, Clement, Achcar, Fiona, Vincent, Isabel M, Goodyear, Carl S, Barrett, Michael P

“…Priming and activating immune stimuli have profound effects on macrophages, however, studies generally evaluate stimuli in isolation rather than in…”
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Different Mutations in a P-type ATPase Transporter in Leishmania Parasites are Associated with Cross-resistance to Two Leading Drugs by Distinct Mechanisms by Fernandez-Prada, Christopher, Vincent, Isabel M, Brotherton, Marie-Christine, Roberts, Mathew, Roy, Gaétan, Rivas, Luis, Leprohon, Philippe, Smith, Terry K, Ouellette, Marc

“…Leishmania infantum is an etiological agent of the life-threatening visceral form of leishmaniasis. Liposomal amphotericin B (AmB) followed by a short…”
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Benzoxaborole treatment perturbs S-adenosyl-L-methionine metabolism in Trypanosoma brucei by Steketee, Pieter C, Vincent, Isabel M, Achcar, Fiona, Giordani, Federica, Kim, Dong-Hyun, Creek, Darren J, Freund, Yvonne, Jacobs, Robert, Rattigan, Kevin, Horn, David, Field, Mark C, MacLeod, Annette, Barrett, Michael P

“…The parasitic protozoan Trypanosoma brucei causes Human African Trypanosomiasis and Nagana in other mammals. These diseases present a major socio-economic…”
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Untargeted metabolomics reveals a lack of synergy between nifurtimox and eflornithine against Trypanosoma brucei by Vincent, Isabel M, Creek, Darren J, Burgess, Karl, Woods, Debra J, Burchmore, Richard J S, Barrett, Michael P

“…A non-targeted metabolomics-based approach is presented that enables the study of pathways in response to drug action with the aim of defining the mode of…”
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Metabolomics Identifies Multiple Candidate Biomarkers to Diagnose and Stage Human African Trypanosomiasis by Vincent, Isabel M, Daly, Rónán, Courtioux, Bertrand, Cattanach, Amy M, Biéler, Sylvain, Ndung'u, Joseph M, Bisser, Sylvie, Barrett, Michael P

“…Treatment for human African trypanosomiasis is dependent on the species of trypanosome causing the disease and the stage of the disease (stage 1 defined by…”
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Sterol 14α-demethylase mutation leads to amphotericin B resistance in Leishmania mexicana by Mwenechanya, Roy, Kovářová, Julie, Dickens, Nicholas J, Mudaliar, Manikhandan, Herzyk, Pawel, Vincent, Isabel M, Weidt, Stefan K, Burgess, Karl E, Burchmore, Richard J S, Pountain, Andrew W, Smith, Terry K, Creek, Darren J, Kim, Dong-Hyun, Lepesheva, Galina I, Barrett, Michael P

“…Amphotericin B has emerged as the therapy of choice for use against the leishmaniases. Administration of the drug in its liposomal formulation as a single…”
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Host-parasite co-metabolic activation of antitrypanosomal aminomethyl-benzoxaboroles by Zhang, Ning, Zoltner, Martin, Leung, Ka-Fai, Scullion, Paul, Hutchinson, Sebastian, Del Pino, Ricardo C, Vincent, Isabel M, Zhang, Yong-Kang, Freund, Yvonne R, Alley, Michael R K, Jacobs, Robert T, Read, Kevin D, Barrett, Michael P, Horn, David, Field, Mark C

“…Recent development of benzoxaborole-based chemistry gave rise to a collection of compounds with great potential in targeting diverse infectious diseases,…”
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The threonine degradation pathway of the Trypanosoma brucei procyclic form: the main carbon source for lipid biosynthesis is under metabolic control by Millerioux, Yoann, Ebikeme, Charles, Biran, Marc, Morand, Pauline, Bouyssou, Guillaume, Vincent, Isabel M., Mazet, Muriel, Riviere, Loïc, Franconi, Jean‐Michel, Burchmore, Richard J. S., Moreau, Patrick, Barrett, Michael P., Bringaud, Frédéric

“…Summary The Trypanosoma brucei procyclic form resides within the digestive tract of its insect vector, where it exploits amino acids as carbon sources…”
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Mitochondrial Proteomics of Antimony and Miltefosine Resistant Leishmania infantum by Vincent, Isabel M, Racine, Gina, Légaré, Danielle, Ouellette, Marc

“…Antimony (SbIII) and miltefosine (MIL) are important drugs for the treatment of parasite infections. The mitochondrion is likely to play a central role in…”
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Small Polar Hits against S. aureus: Screening, Initial Hit Optimization, and Metabolomic Studies by Lim, Andrew S. T, Vincent, Isabel M, Barrett, Michael P, Gilbert, Ian H

“…The global prevalence of antibacterial resistance requires new antibacterial drugs with novel chemical scaffolds and modes of action. It is also vital to…”
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Untargeted Metabolomics To Ascertain Antibiotic Modes of Action by Vincent, Isabel M, Ehmann, David E, Mills, Scott D, Perros, Manos, Barrett, Michael P

“…Deciphering the mode of action (MOA) of new antibiotics discovered through phenotypic screening is of increasing importance. Metabolomics offers a potentially…”
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Metabolomic-based strategies for anti-parasite drug discovery by Vincent, Isabel M, Barrett, Michael P

“…Metabolomics-based studies are proving of great utility in the analysis of modes of action (MOAs) and resistance mechanisms of drugs in parasitic protozoa…”
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Veterinary trypanocidal benzoxaboroles are peptidase-activated prodrugs by Giordani, Federica, Paape, Daniel, Vincent, Isabel M, Pountain, Andrew W, Fernández-Cortés, Fernando, Rico, Eva, Zhang, Ning, Morrison, Liam J, Freund, Yvonne, Witty, Michael J, Peter, Rosemary, Edwards, Darren Y, Wilkes, Jonathan M, van der Hooft, Justin J J, Regnault, Clément, Read, Kevin D, Horn, David, Field, Mark C, Barrett, Michael P

“…Livestock diseases caused by Trypanosoma congolense, T. vivax and T. brucei, collectively known as nagana, are responsible for billions of dollars in lost food…”
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Untargeted metabolomic analysis of miltefosine action in Leishmania infantum reveals changes to the internal lipid metabolism by Vincent, Isabel M., Weidt, Stefan, Rivas, Luis, Burgess, Karl, Smith, Terry K., Ouellette, Marc

“…•Metabolomics reveals 876 metabolites of the Leishmania donovani metabolome.•Miltefosine alters 10% of the metabolome of sensitive but not resistant…”
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Drug resistance in human African trypanosomiasis by Barrett, Michael P, Vincent, Isabel M, Burchmore, Richard J S, Kazibwe, Anne J N, Matovu, Enock

“…Human African trypanosomiasis or 'sleeping sickness' is a neglected tropical disease caused by the parasite Trypanosoma brucei. A decade of intense…”
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LM14 defined medium enables continuous growth of Trypanosoma cruzi by De Paula Lima, Carla V, Batista, Michel, Kugeratski, Fernanda G, Vincent, Isabel M, Soares, Maurilio J, Probst, Christian M, Krieger, Marco A, Marchini, Fabricio K

“…Trypanosoma cruzi, the etiologic agent of Chagas disease, alternates between distinct morphological and functional forms during its life cycle. Axenic…”
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Polymeric hydrophilic interaction liquid chromatography coupled with Orbitrap mass spectrometry and chemometric analysis for untargeted metabolite profiling of natural rice variants by Akram, Muhammad Irfan, Vincent, Isabel M., Siddiqui, Amna Jabbar, Musharraf, Syed Ghulam

“…GC-MS based metabolomics of genetically modified rice varieties are widely reported but involves tedious derivatization processes. Broad-scale LC-MS-based…”
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