Search Results - "Vince, James E."

The intersection of cell death and inflammasome activation by Vince, James E., Silke, John

“…Inflammasomes sense cellular danger to activate the cysteine-aspartic protease caspase-1, which processes precursor interleukin-1β (IL-1β) and IL-18 into their…”
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Inhibitor of Apoptosis Proteins Limit RIP3 Kinase-Dependent Interleukin-1 Activation by Vince, James E., Wong, W. Wei-Lynn, Gentle, Ian, Lawlor, Kate E., Allam, Ramanjaneyulu, O'Reilly, Lorraine, Mason, Kylie, Gross, Olaf, Ma, Stephen, Guarda, Greta, Anderton, Holly, Castillo, Rosa, Häcker, Georg, Silke, John, Tschopp, Jürg

“…Interleukin-1β (IL-1β) is a potent inflammatory cytokine that is usually cleaved and activated by inflammasome-associated caspase-1. To determine whether IL-1β…”
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Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic manner by Conos, Stephanie A., Chen, Kaiwen W., De Nardo, Dominic, Hara, Hideki, Whitehead, Lachlan, Núñez, Gabriel, Masters, Seth L., Murphy, James M., Schroder, Kate, Vaux, David L., Lawlor, Kate E., Lindqvist, Lisa M., Vince, James E.

“…Necroptosis is a physiological cell suicide mechanism initiated by receptor-interacting protein kinase-3 (RIPK3) phosphorylation of mixed-lineage kinase…”
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Caspase-1 Is an Apical Caspase Leading to Caspase-3 Cleavage in the AIM2 Inflammasome Response, Independent of Caspase-8 by Sagulenko, Vitaliya, Vitak, Nazarii, Vajjhala, Parimala R., Vince, James E., Stacey, Katryn J.

“…Canonical inflammasomes are multiprotein complexes that can activate both caspase-1 and caspase-8. Caspase-1 drives rapid lysis of cells by pyroptosis and…”
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RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL by Lawlor, Kate E., Khan, Nufail, Mildenhall, Alison, Gerlic, Motti, Croker, Ben A., D’Cruz, Akshay A., Hall, Cathrine, Kaur Spall, Sukhdeep, Anderton, Holly, Masters, Seth L., Rashidi, Maryam, Wicks, Ian P., Alexander, Warren S., Mitsuuchi, Yasuhiro, Benetatos, Christopher A., Condon, Stephen M., Wong, W. Wei-Lynn, Silke, John, Vaux, David L., Vince, James E.

“…RIPK3 and its substrate MLKL are essential for necroptosis, a lytic cell death proposed to cause inflammation via the release of intracellular molecules…”
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Activated MLKL attenuates autophagy following its translocation to intracellular membranes by Frank, Daniel, Vaux, David L., Murphy, James M., Vince, James E., Lindqvist, Lisa M.

“…ABSTRACT Necroptosis is an inflammatory form of programmed cell death mediated by the pseudokinase mixed-lineage kinase domain-like protein (MLKL). Upon…”
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Oxidative Stress and NLRP3-Inflammasome Activity as Significant Drivers of Diabetic Cardiovascular Complications: Therapeutic Implications by Sharma, Arpeeta, Tate, Mitchel, Mathew, Geetha, Vince, James E, Ritchie, Rebecca H, de Haan, Judy B

“…It is now increasingly appreciated that inflammation is not limited to the control of pathogens by the host, but rather that sterile inflammation which occurs…”
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Macrophages, rather than DCs, are responsible for inflammasome activity in the GM-CSF BMDC model by Erlich, Ziv, Shlomovitz, Inbar, Edry-Botzer, Liat, Cohen, Hadar, Frank, Daniel, Wang, Hanqing, Lew, Andrew M., Lawlor, Kate E., Zhan, Yifan, Vince, James E., Gerlic, Motti

“…Inflammasomes are one of the most important mechanisms for innate immune defense against microbial infection but are also known to drive various inflammatory…”
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RIPK1 Regulates RIPK3-MLKL-Driven Systemic Inflammation and Emergency Hematopoiesis by Rickard, James A., O’Donnell, Joanne A., Evans, Joseph M., Lalaoui, Najoua, Poh, Ashleigh R., Rogers, TeWhiti, Vince, James E., Lawlor, Kate E., Ninnis, Robert L., Anderton, Holly, Hall, Cathrine, Spall, Sukhdeep K., Phesse, Toby J., Abud, Helen E., Cengia, Louise H., Corbin, Jason, Mifsud, Sandra, Di Rago, Ladina, Metcalf, Donald, Ernst, Matthias, Dewson, Grant, Roberts, Andrew W., Alexander, Warren S., Murphy, James M., Ekert, Paul G., Masters, Seth L., Vaux, David L., Croker, Ben A., Gerlic, Motti, Silke, John

“…Upon ligand binding, RIPK1 is recruited to tumor necrosis factor receptor superfamily (TNFRSF) and Toll-like receptor (TLR) complexes promoting prosurvival and…”
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Distinct initiating events underpin the immune and metabolic heterogeneity of KRAS-mutant lung adenocarcinoma by Best, Sarah A., Ding, Sheryl, Kersbergen, Ariena, Dong, Xueyi, Song, Ji-Ying, Xie, Yi, Reljic, Boris, Li, Kaiming, Vince, James E., Rathi, Vivek, Wright, Gavin M., Ritchie, Matthew E., Sutherland, Kate D.

“…The KRAS oncoprotein, a critical driver in 33% of lung adenocarcinoma (LUAD), has remained an elusive clinical target due to its perceived undruggable nature…”
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The ubiquitylation of IL-1β limits its cleavage by caspase-1 and targets it for proteasomal degradation by Vijayaraj, Swarna L., Feltham, Rebecca, Rashidi, Maryam, Frank, Daniel, Liu, Zhengyang, Simpson, Daniel S., Ebert, Gregor, Vince, Angelina, Herold, Marco J., Kueh, Andrew, Pearson, Jaclyn S., Dagley, Laura F., Murphy, James M., Webb, Andrew I., Lawlor, Kate E., Vince, James E.

“…Interleukin-1β (IL-1β) is activated by inflammasome-associated caspase-1 in rare autoinflammatory conditions and in a variety of other inflammatory diseases…”
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The pathogen Candida albicans hijacks pyroptosis for escape from macrophages by Uwamahoro, Nathalie, Verma-Gaur, Jiyoti, Shen, Hsin-Hui, Qu, Yue, Lewis, Rowena, Lu, Jingxiong, Bambery, Keith, Masters, Seth L, Vince, James E, Naderer, Thomas, Traven, Ana

“…The fungal pathogen Candida albicans causes macrophage death and escapes, but the molecular mechanisms remained unknown. Here we used live-cell imaging to…”
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cIAPs and XIAP regulate myelopoiesis through cytokine production in an RIPK1- and RIPK3-dependent manner by Wong, W. Wei-Lynn, Vince, James E., Lalaoui, Najoua, Lawlor, Kate E., Chau, Diep, Bankovacki, Aleksandra, Anderton, Holly, Metcalf, Donald, O'Reilly, Lorraine, Jost, Philipp J., Murphy, James M., Alexander, Warren S., Strasser, Andreas, Vaux, David L., Silke, John

“…Loss of inhibitor of apoptosis proteins (IAPs), particularly cIAP1, can promote production of tumor necrosis factor (TNF) and sensitize cancer cell lines to…”
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Mitochondrial apoptosis is dispensable for NLRP3 inflammasome activation but non-apoptotic caspase-8 is required for inflammasome priming by Allam, Ramanjaneyulu, Lawlor, Kate E, Yu, Eric Chi-Wang, Mildenhall, Alison L, Moujalled, Donia M, Lewis, Rowena S, Ke, Francine, Mason, Kylie D, White, Michael J, Stacey, Katryn J, Strasser, Andreas, O'Reilly, Lorraine A, Alexander, Warren, Kile, Benjamin T, Vaux, David L, Vince, James E

“…A current paradigm proposes that mitochondrial damage is a critical determinant of NLRP3 inflammasome activation. Here, we genetically assess whether…”
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Pyroptosis versus necroptosis: similarities, differences, and crosstalk by Frank, Daniel, Vince, James E.

“…Pyroptosis and necroptosis represent two pathways of genetically encoded necrotic cell death. Although these cell death programmes can protect the host against…”
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XIAP Loss Triggers RIPK3- and Caspase-8-Driven IL-1β Activation and Cell Death as a Consequence of TLR-MyD88-Induced cIAP1-TRAF2 Degradation by Lawlor, Kate E., Feltham, Rebecca, Yabal, Monica, Conos, Stephanie A., Chen, Kaiwen W., Ziehe, Stephanie, Graß, Carina, Zhan, Yifan, Nguyen, Tan A., Hall, Cathrine, Vince, Angelina J., Chatfield, Simon M., D’Silva, Damian B., Pang, Kenneth C., Schroder, Kate, Silke, John, Vaux, David L., Jost, Philipp J., Vince, James E.

“…X-linked Inhibitor of Apoptosis (XIAP) deficiency predisposes people to pathogen-associated hyperinflammation. Upon XIAP loss, Toll-like receptor (TLR)…”
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More to life than death: molecular determinants of necroptotic and non-necroptotic RIP3 kinase signaling by Khan, Nufail, Lawlor, Kate E, Murphy, James M, Vince, James E

“…Highlights • RIP3 kinase activation causes programmed necrosis, referred to as necroptosis. • The RIP3 kinase substrate MLKL is essential for necroptotic cell…”
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Oxidative photocatalysis on membranes triggers non-canonical pyroptosis by Lee, Chaiheon, Park, Mingyu, Wijesinghe, W. C. Bhashini, Na, Seungjin, Lee, Chae Gyu, Hwang, Eunhye, Yoon, Gwangsu, Lee, Jeong Kyeong, Roh, Deok-Ho, Kwon, Yoon Hee, Yang, Jihyeon, Hughes, Sebastian A., Vince, James E., Seo, Jeong Kon, Min, Duyoung, Kwon, Tae-Hyuk

“…Intracellular membranes composing organelles of eukaryotes include membrane proteins playing crucial roles in physiological functions. However, a comprehensive…”
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IFNγ: Priming for death by Vince, James E

“…TNF signaling does not result in cell death unless multiple inhibitory signals are overcome, which can be accomplished by simultaneous signaling through IFNγ…”
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Deletion of IKK2 in haematopoietic cells of adult mice leads to elevated interleukin-6, neutrophilia and fatal gastrointestinal inflammation by Fischer, Karla C., Daunt, Carmel P., Tremblay, Cédric S., Dias, Sheila, Vince, James E., Jabbour, Anissa M.

“…The IκB kinase complex, consisting of IKK1, IKK2 and the regulatory subunit NEMO, is required for NF-κB signalling following the activation of several cell…”
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