Search Results - "Vince, Bradley"

A phase I study of the effect of repeated oral doses of pantoprazole on the pharmacokinetics of a single dose of fedratinib in healthy male subjects by Ogasawara, Ken, Vince, Bradley, Xu, Christine, Zhang, Meng, Palmisano, Maria, Krishna, Gopal

“…Purpose Fedratinib, an oral, selective Janus kinase 2 inhibitor with activity against both wild-type and mutant Janus kinase 2, has pH-dependent solubility,…”
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Oral, intranasal, and intravenous abuse potential of serdexmethylphenidate, a novel prodrug of d-methylphenidate by Shram, Megan J., Setnik, Beatrice, Webster, Lynn, Guenther, Sven, Mickle, Travis C., Braeckman, Rene, Kanski, Jaroslaw, Martin, Andrea, Kelsh, Debra, Vince, Bradley D., Barrett, Andrew C.

“…Serdexmethylphenidate (SDX) chloride (Cl) is a novel prodrug of d-methylphenidate (d-MPH). These studies evaluated the abuse potential of SDX Cl when…”
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A randomized, double-blind, placebo-controlled, crossover study to evaluate the human abuse liability of solriamfetol, a selective dopamine and norepinephrine reuptake inhibitor by Carter, Lawrence P, Henningfield, Jack E, Wang, Y Grace, Lu, Yuan, Kelsh, Debra, Vince, Bradley, Sellers, Edward

“…Background: This study evaluated the human abuse potential of solriamfetol (formerly JZP-110), a selective dopamine and norepinephrine reuptake inhibitor with…”
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The Pharmacodynamics, Pharmacokinetics, and Safety of Arhalofenate in Combination with Febuxostat When Treating Hyperuricemia Associated with Gout by Steinberg, Alexandra S, Vince, Bradley D, Choi, Yun-Jung, Martin, Robert L, McWherter, Charles A, Boudes, Pol F

“…Arhalofenate (ARH), in development for gout, has uricosuric and anti-flare activities. ARH plus febuxostat (FBX) were evaluated in subjects with gout for serum…”
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A randomized, double‐blind, placebo‐controlled study of the kappa opioid receptor antagonist, CERC‐501, in a human laboratory model of smoking behavior by Jones, Jermaine D., Babalonis, Shanna, Marcus, Ronald, Vince, Bradley, Kelsh, Debra, Lofwall, Michelle R., Fraser, Heather, Paterson, Blake, Martinez, Suky, Martinez, Diana M., Nunes, Edward V., Walsh, Sharon L., Comer, Sandra D.

“…Preclinical data indicate that selective kappa opioid receptor antagonists reduce nicotine self‐administration and withdrawal symptoms. The aim of the current…”
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Pharmacokinetics and Abuse Potential of Asalhydromorphone, a Novel Prodrug of Hydromorphone, After Intranasal Administration in Recreational Drug Users by Guenther, Sven, Mickle, Travis C, Barrett, Andrew C, Smith, Adam, Braeckman, Rene, Kelsh, Debra, Vince, Bradley

“…Abstract Objectives Hydromorphone (HM) is a potent μ-opioid receptor agonist with high susceptibility for abuse. A prodrug of hydromorphone, asalhydromorphone…”
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Interaction of Ethanol and Oral ANS‐6637, a Selective ALDH2 Inhibitor in Males: A Randomized, Double‐Blind, Placebo‐Controlled, Single‐Ascending Dose Cohort Study by O’Malley, Stephanie S., Shram, Megan J., Levy‐Cooperman, Naama, Vince, Bradley, Strumph, Peter M., Diamond, Ivan, Blackburn, Brent K.

“…Background ANS‐6637, an orally bioavailable selective and reversible aldehyde dehydrogenase‐2 (ALDH2) inhibitor, is under development for drug and alcohol use…”
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Abuse Potential of Samidorphan: A Phase I, Oxycodone‐, Pentazocine‐, Naltrexone‐, and Placebo‐Controlled Study by Pathak, Sanjeev, Vince, Bradley, Kelsh, Debra, Setnik, Beatrice, Nangia, Narinder, DiPetrillo, Lauren, Puhl, Matthew D., Sun, Lei, Stanford, Arielle D., Ehrich, Elliot

“…Samidorphan is a μ‐opioid receptor antagonist in development for the treatment of schizophrenia, in combination with olanzapine, and major depressive disorder,…”
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A phase 1 study investigating DX-2930 in healthy subjects by Chyung, Yung, MD, Vince, Bradley, DO, Iarrobino, Ryan, BA, Sexton, Dan, PhD, Kenniston, Jon, PhD, Faucette, Ryan, BS, TenHoor, Chris, PharmD, PhD, Stolz, Leslie E., PhD, Stevens, Chris, MD, Biedenkapp, Joseph, PhD, Adelman, Burt, MD

“…Abstract Background DX-2930 is a human monoclonal antibody inhibitor of plasma kallikrein under investigation for long-term prophylaxis of hereditary…”
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Human Abuse Potential of Oral NKTR-181 in Recreational Opioid Users: A Randomized, Double-Blind, Crossover Study by Ge, Xue, Henningfield, Jack E, Siddhanti, Suresh, Jobes, Janet, Lu, Lin, Xie, Sunny, Ziola, Margaret, Kelsh, Debra, Vince, Bradley, Di Fonzo, Carlo J, Tagliaferri, Mary, Zalevsky, Jonathan, Doberstein, Stephen K, Hoch, Ute, Eldon, Michael A

“…Abstract Objective To evaluate the human abuse potential, pharmacokinetics, pharmacodynamics, and safety of oral NKTR-181 (oxycodegol), a novel full mu-opioid…”
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Abuse Potential of Buprenorphine/Samidorphan Combination Compared to Buprenorphine and Placebo: A Phase 1 Randomized Controlled Trial by Pathak, Sanjeev, Vince, Bradley, Kelsh, Debra, Shram, Megan J., Setnik, Beatrice, Lu, Hong, Nangia, Narinder, Stanford, Arielle D., Ehrich, Elliot

“…Buprenorphine/samidorphan combination (BUP/SAM) is an opioid system modulator being investigated as adjunctive treatment for major depressive disorder. BUP/SAM…”
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Phase I Pharmacokinetic Study of Fixed-Dose Combinations of Ibuprofen and Acetaminophen in Healthy Adult and Adolescent Populations by Tarabar, Sanela, Kelsh, Debra, Vince, Bradley, Leyva, Rina, Song, Dongweon, Matschke, Kyle, Kellstein, David E., Meeves, Suzanne, Cruz-Rivera, Mario

“…Introduction A fixed-dose combination (FDC) of ibuprofen and acetaminophen has been developed that provides greater analgesic efficacy than either agent alone…”
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Abuse potential of mirogabalin in recreational polydrug users by Mendell, Jeanne, Levy-Cooperman, Naama, Sellers, Ed, Vince, Bradley, Kelsh, Debra, Lee, James, Warren, Vance, Zahir, Hamim

“…Mirogabalin is a selective calcium channel α δ subunit ligand being developed to treat neuropathic pain. In accordance with US Food and Drug Administration…”
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Effect of steady-state faldaprevir on the pharmacokinetics of steady-state methadone and buprenorphine-naloxone in subjects receiving stable addiction management therapy by Joseph, David, Schobelock, Michael J, Riesenberg, Robert R, Vince, Bradley D, Webster, Lynn R, Adeniji, Abidemi, Elgadi, Mabrouk, Huang, Fenglei

“…The effects of steady-state faldaprevir on the safety, pharmacokinetics, and pharmacodynamics of steady-state methadone and buprenorphine-naloxone were…”
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Psychomotor functioning and alertness with guanfacine extended release in subjects with attention-deficit/hyperactivity disorder by Kollins, Scott H, López, Frank A, Vince, Bradley D, Turnbow, John M, Farrand, Kimberly, Lyne, Andrew, Wigal, Sharon B, Roth, Thomas

“…To determine whether treatment with guanfacine extended release (GXR) in subjects with attention-deficit/hyperactivity disorder (ADHD) disrupted psychomotor…”
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Pharmacokinetics and pharmacodynamics of guanfacine extended release in adolescents aged 13-17 years with attention-deficit/hyperactivity disorder by Martin, Patrick, Satin, Lawrence, Vince, Bradley D., Padilla, Americo F., White, Carla, Corcoran, Mary, Stevenson, Annette, Ermer, James

“…The safety and efficacy of guanfacine extended release (up to 4 mg/day) for attention‐deficit/hyperactivity disorder (ADHD) in children and adolescents aged…”
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Helping Elderly Patients to Avoid Suicide: A Review of Case Reports From a National Veterans Affairs Database by Mills, Peter D, Watts, Bradley Vince, Huh, Terri J.W, Boar, Shoshana, Kemp, Janet

“…ABSTRACTThis study examines the health system factors associated with completed suicide among veterans older than 65 years. All root cause analysis reports of…”
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Systemic Vulnerabilities to Suicide among Veterans from the Iraq and Afghanistan Conflicts: Review of Case Reports from a National Veterans Affairs Database by Mills, Peter D., Huber, Samuel J., Vince Watts, Bradley, Bagian, James P.

“…While suicide among recently returned veterans is of great concern, it is a relatively rare occurrence within individual hospitals and clinics. Root cause…”
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Meta-analysis of the efficacy of treatments for posttraumatic stress disorder by Watts, Bradley V, Schnurr, Paula P, Mayo, Lorna, Young-Xu, Yinong, Weeks, William B, Friedman, Matthew J

“…Posttraumatic stress disorder (PTSD) is an important mental health issue in terms of the number of people affected and the morbidity and functional impairment…”
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Implementation of Evidence-Based Psychotherapies for Posttraumatic Stress Disorder in VA Specialty Clinics by Watts, Bradley V, Shiner, Brian, Zubkoff, Lisa, Carpenter-Song, Elizabeth, Ronconi, Julia M, Coldwell, Craig M

“…ObjectiveThe U.S. Department of Veterans Affairs (VA) has engaged in substantial efforts to promote the use of evidence-based psychotherapies for posttraumatic…”
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