Search Results - "Vinader, V"

Control of the stereochemistry of C14 hydroxyl during the total synthesis of withanolide E and physachenolide C by Anees, M, Nayak, S, Afarinkia, K, Vinader, V

“…The stereochemical outcome of the epoxidation of Δ cholestanes with mCPBA is controlled by the steric bulk of a C17 substituent. When the C17 is in the β…”
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Carbasugar probes to explore the enzyme binding pocket at the anomeric position: application to the design of Golgi mannosidase II inhibitors by Vinader, M V, Afarinkia, K

“…A methodology is described for the highly efficient and divergent synthesis of pseudosugars which allows the stereoselective introduction of polar groups at…”
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Control of the stereochemistry of C14 hydroxyl during the total synthesis of withanolide E and physachenolide CElectronic supplementary information (ESI) available: For detailed experimental procedure and characterisation of all compounds. CCDC 1861117. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c8ra08540d by Anees, M, Nayak, S, Afarinkia, K, Vinader, V

“…The stereochemical outcome of the epoxidation of Δ 14-15 cholestanes with mCPBA is controlled by the steric bulk of a C17 substituent. When the C17 is in the β…”
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Discovery of an Orally Bioavailable NK1 Receptor Antagonist, (2S,3S)-(2-Methoxy-5-tetrazol-1-ylbenzyl)(2-phenylpiperidin-3-yl)amine (GR203040), with Potent Antiemetic Activity by Ward, Peter, Armour, Duncan R, Bays, David E, Evans, Brian, Giblin, Gerard M. P, Heron, Nicola, Hubbard, Tania, Liang, Kai, Middlemiss, David

“…The antiemetic, pharmacokinetic, and metabolic profile of CP-99,994, a potent NK1 receptor antagonist, has been carefully evaluated. As a result we began a…”
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Tetrazole NK1 receptor antagonists: The identification of an exceptionally potent orally active antiemetic compound by Armour, D.R., Chung, K.M.L., Congreve, M., Evans, B., Guntrip, S., Hubbard, T., Kay, C., Middlemiss, D., Mordaunt, J.E., Pegg, N.A., Vinader, M.V., Ward, P., Watson, S.P.

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Fused pyrimidines by a tandem aza-Wittig/electrocyclic ring closure strategy: synthesis of pyrazolo[3,4-d]pyrimidine, [1,2,3]triazolo[4,5-d]pyrimidine, and thiazolo[4,5-d]pyrimidine derivatives by Molina, Pedro, Arques, Antonio, Vinader, Maria Victoria, Becher, Jan, Brondum, Klaus

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An efficient preparation of macrocycles containing two tetra-coordinate phosphorus atoms by Molina, P., Alajarín, M., Arques, A., Sánchez-Andrada, P., Vidal, A., Vinader, M.V.

“…The Staudinger reaction between bis(azides) and bis(phosphines) under mild conditions provides macrocyclic bis(iminophosphoranes) (at least 12-membered rings)…”
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1α,25-Dihydroxyvitamin D3 analogs featuring aromatic and heteroaromatic rings : design, synthesis, and preliminary biological testing by POSNER, G. H, ZHENGONG LI, WHITE, M. C, VINADER, V, TAKEUCHI, K, GUGGINO, S. E, DOLAN, P, KANSLER, T. W

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Diels-Alder cycloadditions using nucleophilic 2-pyridones. Regiocontrolled and stereocontrolled synthesis of unsaturated, bridged, bicyclic lactams by Posner, Gary H, Vinader, Victoria, Afarinkia, Kamyar

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Design and Synthesis of New Nonsteroidal Glucocorticoid Modulators through Application of an “Agreement Docking” Method by Barker, Mike, Clackers, Margaret, Demaine, Derek A, Humphreys, Davina, Johnston, Michael J, Jones, Haydn T, Pacquet, Francois, Pritchard, John M, Salter, Mark, Shanahan, Stephen E, Skone, Philip A, Vinader, Victoria M, Uings, Iain, McLay, Iain M, Macdonald, Simon J. F

“…Structurally related glucocorticoid receptor (GR) binders were docked into the GR active site to select the binding mode closest to the true docking mode. This…”
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1 alpha,25-dihydroxyvitamin D3 analogs featuring aromatic and heteroaromatic rings: design, synthesis, and preliminary biological testing by Posner, G H, Li, Z, White, M C, Vinader, V, Takeuchi, K, Guggino, S E, Dolan, P, Kensler, T W

“…Aromatic compounds 2a-c, analogs of 1 alpha, 25-dihydroxyvitamin (calcitriol, 1), and heteroaromatic compounds 4a-c and 5a-c, analogs of 19-nor-1 alpha,…”
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1 alpha ,25-Dihydroxyvitamin D sub(3) analogs featuring aromatic and heteroaromatic rings: Design, synthesis, and preliminary biological testing by Posner, G H, Li, Zhengong, White, M C, Vinader, V, Takeuchi, K, Guggino, SE, Dolan, P, Kensler, T W

“…Aromatic compounds, 2a-c analogs of 1 alpha ,25-dihydroxyvitamin, and heteroaromatic compounds 4a-e and 5a-2c, analogs of 19-nor-1 alpha ,25-dihydroxyvitamin D…”
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Solid-phase development of a L-hydroxybenzotriazole linker for heterocycle synthesis using analytical constructs by Scicinski, J J, Congreve, M S, Jamieson, C, Ley, S V, Newman, E S, Vinader, V M, Carr, R A

“…The development of a 1-hydroxybenzotriazole linker for the synthesis of heterocyclic derivatives is described, utilizing analytical construct methodology to…”
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Iminophosphorane-mediated synthesis of 2H-indazole derivatives : preparation of 2,3-diamino-2H-indazoles by intramolecular trapping of phosphazides an d1H-1,2,4-triazolo[2,3-b]indazoles by a tandem aza-wittig/heterocumulene-mediated strategy by MOLINA, P, ARQUES, A, VINADER, M. V

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Spiro-piperidine non-peptide neurokinin-1 receptor antagonists by Armour, D.R., Watson, S.P., Pegg, N.A., Heron, N.M., Middlemiss, D., Chan, C., Cholerton, T.J., Hubbard, T., Vinader, M.V., Davies, H.G., Cocker, J.D., Bays, D.E., Ward, P.

“…The synthesis and activity of a novel spiro-piperidine non-peptide antagonist (2) of the neurokinin-1 (NK 1) receptor is described. Despite having essentially…”
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3-substituted-1,2,4-oxadiazolin-5-one; A useful amidine precursor and protecting group by Bolton, Richard E, Coote, Steven J, Finch, Harry, Lowdon, Andrew, Pegg, Neil, Vinader, M Victoria

“…5-Benzyloxy-1,2,4-oxadiazoles and 1,2,4-oxadiazolin-5-ones are useful precursors to, and protecting groups for the amidine moiety. The latter compounds are…”
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Iminophosphorane-mediated synthesis of 2H-indazole derivatives: preparation of 2,3-diamino-2H-indazoles by intramolecular trapping of phosphazides and 1H-1,2,4-triazolo[2,3-b]indazoles by a tandem aza-Wittig/heterocumulene-mediated strategy by Molina, Pedro, Arques, Antonio, Vinader, Maria Victoria

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Solid-Phase Development of a 1-Hydroxybenzotriazole Linker for Heterocycle Synthesis Using Analytical Constructs by Scicinski, Jan J, Congreve, Miles S, Jamieson, Craig, Ley, Steven V, Newman, Emma S, Vinader, Victoria M, Carr, Robin A. E

“…The development of a 1-hydroxybenzotriazole linker for the synthesis of heterocyclic derivatives is described, utilizing analytical construct methodology to…”
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