Search Results - "Viña, Dolores"

Phytochemical Analysis and Antiproliferative Activity of Ulex gallii Planch. (Fabaceae), a Medicinal Plant from Galicia (Spain) by Bada, Lucía, Pereira, Renato B, Pereira, David M, Lores, Marta, Celeiro, María, Quezada, Elías, Uriarte, Eugenio, Gil-Longo, José, Viña, Dolores

“…The genus comprises thirteen accepted species of perennial shrubs in the family Fabaceae. In Galicia (Spain) many of these are considered spontaneous…”
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New flavonoid - N,N-dibenzyl(N-methyl)amine hybrids: Multi-target-directed agents for Alzheimer´s disease endowed with neurogenic properties by Estrada-Valencia, Martín, Herrera-Arozamena, Clara, Pérez, Concepción, Viña, Dolores, Morales-García, José A., Pérez-Castillo, Ana, Ramos, Eva, Romero, Alejandro, Laurini, Erik, Pricl, Sabrina, Rodríguez-Franco, María Isabel

“…The design of multi-target directed ligands (MTDLs) is a valid approach for obtaining effective drugs for complex pathologies. MTDLs that combine neuro-repair…”
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Heterocycle-containing tranylcypromine derivatives endowed with high anti-LSD1 activity by Fioravanti, Rossella, Rodriguez, Veronica, Caroli, Jonatan, Chianese, Ugo, Benedetti, Rosaria, Di Bello, Elisabetta, Noce, Beatrice, Zwergel, Clemens, Corinti, Davide, Viña, Dolores, Altucci, Lucia, Mattevi, Andrea, Valente, Sergio, Mai, Antonello

“…As regioisomers/bioisosteres of 1a, a 4-phenylbenzamide tranylcypromine (TCP) derivative previously disclosed by us, we report here the synthesis and…”
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Coumarin analogue 3-methyl-7H-furo[3,2-g] chromen-7-one as a possible antiparkinsonian agent by Olaya, María Del Pilar, Vergel, Nadezdha Esperanza, López, José Luis, Viña, María Dolores, Guerrero, Mario Francisco

“…Parkinson's disease is the second most common neurodegenerative disease. Monoamine oxidase B inhibitors are used in the treatment of this disease concomitantly…”
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Nanomolar resveratrol reduces early alterations of pancreatitis and pancreatic cancer in pancreatic acinar cells by Pereira, Thiago M.C., Carvalho, Glaucimeire R., Luaces-Regueira, María, Bugallo-Casal, Ana, Iglesias-Mejuto, Ana, Nugteren, Lonneke, Schmidt, Martina, Viña, Dolores, Vasquez, Elisardo C., Campos-Toimil, Manuel

“…Resveratrol is a natural phytoalexin present in human diet with a potential beneficial effect in many diseases including chronic and acute pancreatitis, a…”
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Synthesis and Study of a Series of 3-Arylcoumarins as Potent and Selective Monoamine Oxidase B Inhibitors by Matos, Maria J, Terán, Carmen, Pérez-Castillo, Yunierkis, Uriarte, Eugenio, Santana, Lourdes, Viña, Dolores

“…New series of 6-substituted-3-arylcoumarins displaying several alkyl, hydroxyl, halogen, and alkoxy groups in the two benzene rings have been designed,…”
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Novel 2-pheynlbenzofuran derivatives as selective butyrylcholinesterase inhibitors for Alzheimer’s disease by Kumar, Amit, Pintus, Francesca, Di Petrillo, Amalia, Medda, Rosaria, Caria, Paola, Matos, Maria João, Viña, Dolores, Pieroni, Enrico, Delogu, Francesco, Era, Benedetta, Delogu, Giovanna L., Fais, Antonella

“…Alzheimer’s disease (AD) is a neurodegenerative disorder representing the leading cause of dementia and is affecting nearly 44 million people worldwide. AD is…”
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Dual inhibitors of monoamine oxidase and cholinesterase for the treatment of Alzheimer disease by Yáñez, Matilde, Viña, Dolores

“…Alzheimer's disease (AD) is the most common neurodegenerative disorder and the most prevalent cause of dementia with ageing. The etiology of this illness is…”
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Coumarin-Resveratrol-Inspired Hybrids as Monoamine Oxidase B Inhibitors: 3-Phenylcoumarin versus trans -6-Styrylcoumarin by Mellado, Marco, González, César, Mella, Jaime, Aguilar, Luis F, Celik, Ismail, Borges, Fernanda, Uriarte, Eugenio, Delogu, Giovanna, Viña, Dolores, Matos, Maria J

“…Monoamine oxidases (MAOs) are attractive targets in drug design. The inhibition of one of the isoforms (A or B) is responsible for modulating the levels of…”
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Curcumin–Coumarin Hybrid Analogues as Multitarget Agents in Neurodegenerative Disorders by Quezada, Elías, Rodríguez-Enríquez, Fernanda, Laguna, Reyes, Cutrín, Elena, Otero, Francisco, Uriarte, Eugenio, Viña, Dolores

“…Neurodegenerative diseases have a complex nature which highlights the need for multitarget ligands to address the complementary pathways involved in these…”
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Alignment-Free Prediction of a Drug−Target Complex Network Based on Parameters of Drug Connectivity and Protein Sequence of Receptors by Viña, Dolores, Uriarte, Eugenio, Orallo, Francisco, González-Díaz, Humberto

“…There are many drugs described with very different affinity to a large number of receptors. In this work, we selected drug−receptor pairs (DRPs) of…”
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Synthesis and evaluation of 6-methyl-3-phenylcoumarins as potent and selective MAO-B inhibitors by Matos, Maria Joao, Viña, Dolores, Picciau, Carmen, Orallo, Francisco, Santana, Lourdes, Uriarte, Eugenio

“…A series of 6-methyl-3-phenylcoumarins with methoxyphenyl or hydroxyphenyl substituents in the position 3 were synthesized and evaluated as monoamine oxidase A…”
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cAMP Compartmentalization in Cerebrovascular Endothelial Cells: New Therapeutic Opportunities in Alzheimer’s Disease by Viña, Dolores, Seoane, Nuria, Vasquez, Elisardo C., Campos-Toimil, Manuel

“…The vascular hypothesis used to explain the pathophysiology of Alzheimer’s disease (AD) suggests that a dysfunction of the cerebral microvasculature could be…”
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Herbal natural products as a source of monoamine oxidase inhibitors: a review by Viña, Dolores, Serra, Silvia, Lamela, Manuel, Delogu, Giovanna

“…Drugs of natural origin still play a major role in the treatment of many diseases and as lead structures for the development of new synthetic drug substances…”
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Combined 3D-QSAR and docking analysis for the design and synthesis of chalcones as potent and selective monoamine oxidase B inhibitors by Mellado, Marco, González, César, Mella, Jaime, Aguilar, Luis F., Viña, Dolores, Uriarte, Eugenio, Cuellar, Mauricio, Matos, Maria J.

“…[Display omitted] •QSAR methodologies are described as theoretical approaches to speed up drug discovery.•Docking calculations proved to be important tools to…”
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Focusing on new monoamine oxidase inhibitors: differently substituted coumarins as an interesting scaffold by Matos, Maria João, Viña, Dolores, Vazquez-Rodriguez, Saleta, Uriarte, Eugenio, Santana, Lourdes

“…It is commonly accepted that monoamine oxidase (MAO) may play a critical role in the regulation of the central nervous system activity and contribute to the…”
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A new series of 3-phenylcoumarins as potent and selective MAO-B inhibitors by Matos, Maria Joao, Viña, Dolores, Quezada, Elias, Picciau, Carmen, Delogu, Giovanna, Orallo, Francisco, Santana, Lourdes, Uriarte, Eugenio

“…6-Methyl-3-phenylcoumarins 3–6 were design, synthesized and evaluated as monoamine oxidase A and B (MAO-A and MAO-B) inhibitors. The synthesis of these new…”
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3-Arylcoumarins as highly potent and selective monoamine oxidase B inhibitors: Which chemical features matter? by Mellado, Marco, Mella, Jaime, González, César, Viña, Dolores, Uriarte, Eugenio, Matos, Maria J.

“…[Display omitted] •QSAR models as theoretical tools to accelerate drug discovery.•Docking calculations as theoretical tools to support drug…”
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Chromone, a Privileged Scaffold for the Development of Monoamine Oxidase Inhibitors by Gaspar, Alexandra, Silva, Tiago, Yáñez, Matilde, Vina, Dolores, Orallo, Franscisco, Ortuso, Francesco, Uriarte, Eugenio, Alcaro, Stefano, Borges, Fernanda

“…Two series of novel chromone derivatives were synthesized and investigated for their ability to inhibit the activity of monoamine oxidase. The SAR data…”
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Quantitative Structure−Activity Relationship and Complex Network Approach to Monoamine Oxidase A and B Inhibitors by Santana, Lourdes, González-Díaz, Humberto, Quezada, Elías, Uriarte, Eugenio, Yáñez, Matilde, Viña, Dolores, Orallo, Francisco

“…The work provides a new model for the prediction of the MAO-A and -B inhibitor activity by the use of combined complex networks and QSAR methodologies. On the…”
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