Search Results - "Vilstrup Johansen, Jens"

Fbxl10/Kdm2b Recruits Polycomb Repressive Complex 1 to CpG Islands and Regulates H2A Ubiquitylation by Wu, Xudong, Johansen, Jens Vilstrup, Helin, Kristian

“…Polycomb repressive complex 1 (PRC1) catalyzes lysine 119 monoubiquitylation on H2A (H2AK119ub1) and regulates pluripotency in embryonic stem cells (ESCs)…”
Get full text

The Histone Methyltransferase and Putative Oncoprotein MMSET Is Overexpressed in a Large Variety of Human Tumors by RYE HUDLEBUSCH, Heidi, SANTONI-RUGIU, Eric, SIMON, Ronald, RALFKIAER, Elisabeth, HOLM ROSSING, Henrik, VILSTRUP JOHANSEN, Jens, JØRGENSEN, Mette, SAUTER, Guido, HELIN, Kristian

“…Multiple myeloma SET (Suppressor of variegation, Enhancer of zeste, and Trithorax) domain (MMSET) is a histone lysine methyltransferase deregulated in a…”
Get full text

PLZF targets developmental enhancers for activation during osteogenic differentiation of human mesenchymal stem cells by Agrawal Singh, Shuchi, Lerdrup, Mads, Gomes, Ana-Luisa R, van de Werken, Harmen Jg, Vilstrup Johansen, Jens, Andersson, Robin, Sandelin, Albin, Helin, Kristian, Hansen, Klaus

“…The PLZF transcription factor is essential for osteogenic differentiation of hMSCs; however, its regulation and molecular function during this process is not…”
Get full text

JMJD-5/KDM8 regulates H3K36me2 and is required for late steps of homologous recombination and genome integrity by Amendola, Pier Giorgio, Zaghet, Nico, Ramalho, João J, Vilstrup Johansen, Jens, Boxem, Mike, Salcini, Anna Elisabetta

“…The eukaryotic genome is organized in a three-dimensional structure called chromatin, constituted by DNA and associated proteins, the majority of which are…”
Get full text

Gene Silencing Triggers Polycomb Repressive Complex 2 Recruitment to CpG Islands Genome Wide by Riising, Eva Madi, Comet, Itys, Leblanc, Benjamin, Wu, Xudong, Johansen, Jens Vilstrup, Helin, Kristian

“…Polycomb group (PcG) proteins are required for normal differentiation and development and are frequently deregulated in cancer. PcG proteins are involved in…”
Get full text

Accurate Recycling of Parental Histones Reproduces the Histone Modification Landscape during DNA Replication by Reverón-Gómez, Nazaret, González-Aguilera, Cristina, Stewart-Morgan, Kathleen R., Petryk, Nataliya, Flury, Valentin, Graziano, Simona, Johansen, Jens Vilstrup, Jakobsen, Janus Schou, Alabert, Constance, Groth, Anja

“…Chromatin organization is disrupted genome-wide during DNA replication. On newly synthesized DNA, nucleosomes are assembled from new naive histones and old…”
Get full text

EZH2 is a potential therapeutic target for H3K27M-mutant pediatric gliomas by Mohammad, Faizaan, Weissmann, Simon, Leblanc, Benjamin, Pandey, Deo P, Højfeldt, Jonas W, Comet, Itys, Zheng, Chunqin, Johansen, Jens Vilstrup, Rapin, Nicolas, Porse, Bo T, Tvardovskiy, Andrey, Jensen, Ole N, Olaciregui, Nagore G, Lavarino, Cinzia, Suñol, Mariona, de Torres, Carmen, Mora, Jaume, Carcaboso, Angel M, Helin, Kristian

“…Although mutant H3K27M histones inhibit PRC2 in diffuse intrinsic pontine gliomas, these tumors exhibit significant amounts of PRC2 activity. The repression of…”
Get full text

KDM4A regulates the maternal-to-zygotic transition by protecting broad H3K4me3 domains from H3K9me3 invasion in oocytes by Sankar, Aditya, Lerdrup, Mads, Manaf, Adeel, Johansen, Jens Vilstrup, Gonzalez, Javier Martin, Borup, Rehannah, Blanshard, Robert, Klungland, Arne, Hansen, Klaus, Andersen, Claus Yding, Dahl, John Arne, Helin, Kristian, Hoffmann, Eva R.

“…The importance of germline-inherited post-translational histone modifications on priming early mammalian development is just emerging 1 – 4 . Histone H3 lysine…”
Get full text

The Histone Demethylases JMJD1A and JMJD2B Are Transcriptional Targets of Hypoxia-inducible Factor HIF by Beyer, Sophie, Kristensen, Malene Maag, Jensen, Kim Steen, Johansen, Jens Vilstrup, Staller, Peter

“…Posttranslational histone modifications serve to store epigenetic information and control both nucleosome assembly and recruitment of non-histone proteins…”
Get full text

Histone H4K20 methylation mediated chromatin compaction threshold ensures genome integrity by limiting DNA replication licensing by Shoaib, Muhammad, Walter, David, Gillespie, Peter J., Izard, Fanny, Fahrenkrog, Birthe, Lleres, David, Lerdrup, Mads, Johansen, Jens Vilstrup, Hansen, Klaus, Julien, Eric, Blow, J. Julian, Sørensen, Claus S.

“…The decompaction and re-establishment of chromatin organization immediately after mitosis is essential for genome regulation. Mechanisms underlying chromatin…”
Get full text

The histone lysine demethylase JMJD3/KDM6B is recruited to p53 bound promoters and enhancer elements in a p53 dependent manner by Williams, Kristine, Christensen, Jesper, Rappsilber, Juri, Nielsen, Anders Lærke, Johansen, Jens Vilstrup, Helin, Kristian

“…The JmjC domain-containing protein JMJD3/KDM6B catalyses the demethylation of H3K27me3 and H3K27me2. JMJD3 appears to be highly regulated at the…”
Get full text

Correction: A Screen Identifies the Oncogenic Micro-RNA miR-378a-5p as a Negative Regulator of Oncogene-Induced Senescence by Kooistra, Susanne Marije, Nørgaard, Lise Christine Rudkjær, Lees, Michael James, Steinhauer, Cornelia, Johansen, Jens Vilstrup, Helin, Kristian

“…[This corrects the article DOI: 10.1371/journal.pone.0091034.]…”
Get full text

SWI/SNF Subunits SMARCA4, SMARCD2 and DPF2 Collaborate in MLL-Rearranged Leukaemia Maintenance by Cruickshank, V Adam, Sroczynska, Patrycja, Sankar, Aditya, Miyagi, Satoru, Rundsten, Carsten Friis, Johansen, Jens Vilstrup, Helin, Kristian

“…Alterations in chromatin structure caused by deregulated epigenetic mechanisms collaborate with underlying genetic lesions to promote cancer. SMARCA4/BRG1, a…”
Get full text

A screen identifies the oncogenic micro-RNA miR-378a-5p as a negative regulator of oncogene-induced senescence by Kooistra, Susanne Marije, Nørgaard, Lise Christine Rudkjær, Lees, Michael James, Steinhauer, Cornelia, Johansen, Jens Vilstrup, Helin, Kristian

“…Oncogene-induced senescence (OIS) can occur in response to hyperactive oncogenic signals and is believed to be a fail-safe mechanism protecting against…”
Get full text

A genetic screen identifies BRCA2 and PALB2 as key regulators of G2 checkpoint maintenance by Menzel, Tobias, Nähse-Kumpf, Viola, Kousholt, Arne Nedergaard, Klein, Ditte Kjærsgaard, Lund-Andersen, Christin, Lees, Michael, Johansen, Jens Vilstrup, Syljuåsen, Randi G, Sørensen, Claus Storgaard

“…To identify key connections between DNA‐damage repair and checkpoint pathways, we performed RNA interference screens for regulators of the ionizing…”
Get full text

An interactive environment for agile analysis and visualization of ChIP-sequencing data by Lerdrup, Mads, Johansen, Jens Vilstrup, Agrawal-Singh, Shuchi, Hansen, Klaus

“…EaSeq, a user-friendly and freely available software tool, offers fast and comprehensive ChIP-sequencing data analyses, enabling experimentalists to easily…”
Get full text

Jmjd2/Kdm4 demethylases are required for expression of Il3ra and survival of acute myeloid leukemia cells by Agger, Karl, Miyagi, Satoru, Pedersen, Marianne Terndrup, Kooistra, Susanne M, Johansen, Jens Vilstrup, Helin, Kristian

“…Acute myeloid leukemias (AMLs) with a rearrangement of the mixed-linage leukemia (MLL) gene are aggressive hematopoietic malignancies. Here, we explored the…”
Get full text

Continual removal of H3K9 promoter methylation by Jmjd2 demethylases is vital for ESC self-renewal and early development by Pedersen, Marianne Terndrup, Kooistra, Susanne Marije, Radzisheuskaya, Aliaksandra, Laugesen, Anne, Johansen, Jens Vilstrup, Hayward, Daniel Geoffrey, Nilsson, Jakob, Agger, Karl, Helin, Kristian

“…Chromatin‐associated proteins are essential for the specification and maintenance of cell identity. They exert these functions through modulating and…”
Get full text

Tu1251 EARLY IMPAIRMENT OF REGENERATION AND ENGAGEMENT OF PRO-FIBROTIC SIGNALING IN ULCERATIVE COLITIS IN RESPONSE TO EXPERIMENTAL INTESTINAL INJURY by Seidelin, Jakob B., Bronze, Mariana, Attauabi, Mohamed, woetmann, anders, Riis, Lene, Johansen, Jens Vilstrup, Bjerrum, Jacob T.

Get full text

Effects of a single dose of psilocybin on behaviour, brain 5-HT2A receptor occupancy and gene expression in the pig by Donovan, Lene Lundgaard, Johansen, Jens Vilstrup, Ros, Nídia Fernandez, Jaberi, Elham, Linnet, Kristian, Johansen, Sys Stybe, Ozenne, Brice, Issazadeh-Navikas, Shohreh, Hansen, Hanne Demant, Knudsen, Gitte Moos

“…•Pigs respond to 0.08 mg/kg psilocybin i.v. with headshakes, scratching and rubbing behaviour.•A similar dose produce a cerebral 5-HT2A receptor occupancy of…”
Get full text