Search Results - "Villunger, A"

Noxa: at the tip of the balance between life and death by Ploner, C, Kofler, R, Villunger, A

“…Among all Bcl2 homology domain 3 (BH3)-only proteins known to date, APR/PMAIP1/Noxa, albeit showing weak proapoptotic potential on its own, appears to be…”
Get full text

Essential versus accessory aspects of cell death: recommendations of the NCCD 2015 by Galluzzi, L, Bravo-San Pedro, J M, Vitale, I, Aaronson, S A, Abrams, J M, Adam, D, Alnemri, E S, Andrews, D, Baehrecke, E H, Bazan, N G, Bertrand, M J, Blagosklonny, M V, Blomgren, K, Borner, C, Bredesen, D E, Brenner, C, Campanella, M, Candi, E, Cecconi, F, Chan, F K, Chandel, N S, Cheng, E H, Chipuk, J E, Cidlowski, J A, Ciechanover, A, Dawson, V L, De Laurenzi, V, De Maria, R, Debatin, K-M, Di Daniele, N, Dixit, V M, Dynlacht, B D, El-Deiry, W S, Fimia, G M, Flavell, R A, Garrido, C, Green, D R, Gronemeyer, H, Hajnoczky, G, Hardwick, J M, Hengartner, M O, Ichijo, H, Joseph, B, Jost, P J, Kaufmann, T, Kepp, O, Klionsky, D J, Knight, R A, Kumar, S, Lemasters, J J, Levine, B, Linkermann, A, Lipton, S A, Lockshin, R A, López-Otín, C, Lugli, E, Madeo, F, Malorni, W, Marine, J-C, Martin, S J, Martinou, J-C, Medema, J P, Meier, P, Melino, S, Mizushima, N, Moll, U, Muñoz-Pinedo, C, Nuñez, G, Oberst, A, Panaretakis, T, Penninger, J M, Peter, M E, Piacentini, M, Pinton, P, Prehn, J H, Puthalakath, H, Rabinovich, G A, Ravichandran, K S, Rizzuto, R, Rodrigues, C M, Rubinsztein, D C, Rudel, T, Stockwell, B R, Szabadkai, G, Tait, S W, Tang, H L, Tavernarakis, N, Tsujimoto, Y, Vanden Berghe, T, Vandenabeele, P, Villunger, A, Wagner, E F, Walczak, H, White, E, Wood, W G, Yuan, J, Zakeri, Z, Zhivotovsky, B, Melino, G, Kroemer, G

“…Cells exposed to extreme physicochemical or mechanical stimuli die in an uncontrollable manner, as a result of their immediate structural breakdown. Such an…”
Get full text

PARP-2 sustains erythropoiesis in mice by limiting replicative stress in erythroid progenitors by Farrés, J, Llacuna, L, Martin-Caballero, J, Martínez, C, Lozano, J J, Ampurdanés, C, López-Contreras, A J, Florensa, L, Navarro, J, Ottina, E, Dantzer, F, Schreiber, V, Villunger, A, Fernández-Capetillo, O, Yélamos, J

“…Erythropoiesis is a tightly regulated process in which multipotential hematopoietic stem cells produce mature red blood cells. Here we show that deletion of…”
Get full text

Targeting the Bcl-2-regulated apoptosis pathway by BH3 mimetics: a breakthrough in anticancer therapy? by Labi, V, Grespi, F, Baumgartner, F, Villunger, A

“…Induction of apoptosis in tumor cells by direct activation of the Bcl-2-regulated apoptosis pathway by small molecule drugs carries high hopes to overcome the…”
Get full text

How important are post-translational modifications in p53 for selectivity in target-gene transcription and tumour suppression? by Olsson, A, Manzl, C, Strasser, A, Villunger, A

“…A number of elegant studies exploring the consequences of expression of various mutant forms of p53 in mice have been published over the last years. The…”
Get full text

In several cell types tumour suppressor p53 induces apoptosis largely via Puma but Noxa can contribute by Michalak, E M, Villunger, A, Adams, J M, Strasser, A

“…The ability of p53 to induce apoptosis in cells with damaged DNA is thought to contribute greatly to its tumour suppressor function. P53 has been proposed to…”
Get full text

The enigma of caspase-2: the laymen's view by Krumschnabel, G, Sohm, B, Bock, F, Manzl, C, Villunger, A

“…Proteolysis of cellular substrates by caspases (cysteine-dependent aspartate-specific proteases) is one of the hallmarks of apoptotic cell death. Although the…”
Get full text

BH3-only proteins in cell death initiation, malignant disease and anticancer therapy by Labi, V, Erlacher, M, Kiessling, S, Villunger, A

“…Induction of apoptosis in tumour cells, either by direct activation of the death receptor pathway using agonistic antibodies or recombinant ligands, or direct…”
Get full text

MYC selects against reduced BCL2A1/A1 protein expression during B cell lymphomagenesis by Sochalska, M, Schuler, F, Weiss, J G, Prchal-Murphy, M, Sexl, V, Villunger, A

“…Rearrangements of MYC or ABL proto-oncogenes lead to deregulated expression of key-regulators of cell cycle and cell survival, thereby constituting important…”
Get full text

Conditional knockdown of BCL2A1 reveals rate-limiting roles in BCR-dependent B-cell survival by Sochalska, M, Ottina, E, Tuzlak, S, Herzog, S, Herold, M, Villunger, A

“…Bcl2 family proteins control mitochondrial apoptosis and its members exert critical cell type and differentiation stage-specific functions, acting as barriers…”
Get full text

Bcl-2-regulated cell death signalling in the prevention of autoimmunity by Tischner, D, Woess, C, Ottina, E, Villunger, A

“…Cell death mediated through the intrinsic, Bcl-2-regulated mitochondrial apoptosis signalling pathway is critical for lymphocyte development and the…”
Get full text

Bim and Bmf in tissue homeostasis and malignant disease by Piñon, J D, Labi, V, Egle, A, Villunger, A

“…Among all BH3-only proteins known to date, most information is available on the biological role and function of Bim (Bcl-2 interacting mediator of cell…”
Get full text

Caspases uncouple p27(Kip1) from cell cycle regulated degradation and abolish its ability to stimulate cell migration and invasion by Podmirseg, S R, Jäkel, H, Ranches, G D, Kullmann, M K, Sohm, B, Villunger, A, Lindner, H, Hengst, L

“…In addition to their role in programmed cell death, caspases exert non-lethal functions in diverse developmental processes including cell differentiation or…”
Get full text

The tumor-modulatory effects of Caspase-2 and Pidd1 do not require the scaffold protein Raidd by Peintner, L, Dorstyn, L, Kumar, S, Aneichyk, T, Villunger, A, Manzl, C

“…The receptor-interacting protein-associated ICH-1/CED-3 homologous protein with a death domain (RAIDD/CRADD) functions as a dual adaptor and is a constituent…”
Get full text

The BCL2 rheostat in glucocorticoid-induced apoptosis of acute lymphoblastic leukemia by Ploner, C, Rainer, J, Niederegger, H, Eduardoff, M, Villunger, A, Geley, S, Kofler, R

“…Glucocorticoid (GC)-induced apoptosis is essential in the treatment of acute lymphoblastic leukemia (ALL) and related malignancies. Pro- and anti-apoptotic…”
Get full text

PB2166: TET ENZYMES PROTECT AGAINST FATAL LYMPHOPROLIFERATION by Spoeck, S., Kinz, N., Villunger, A., Labi, V.

Get full text

Correction to: The BH3-only protein Bad is dispensable for TNF-mediated cell death by Ottina, E., Sochalska, M., Sgonc, R., Villunger, A.

“…Since publication of this article, the authors wished to draw attention to an error in the materials section as a result of which they have been mis-cited (…”
Get full text

Combined loss of the BH3-only proteins Bim and Bmf restores B-cell development and function in TACI-Ig transgenic mice by Woess, C, Tuzlak, S, Labi, V, Drach, M, Bertele, D, Schneider, P, Villunger, A

“…Terminal differentiation of B cells depends on two interconnected survival pathways, elicited by the B-cell receptor (BCR) and the BAFF receptor (BAFF-R),…”
Get full text

MAP3K11 is a tumor suppressor targeted by the oncomiR miR-125b in early B cells by Knackmuss, U, Lindner, S E, Aneichyk, T, Kotkamp, B, Knust, Z, Villunger, A, Herzog, S

“…MicroRNAs (miRNAs) are a class of small, non-coding RNAs that posttranscriptionally regulate gene expression and thereby control most, if not all, biological…”
Get full text

Can the analysis of BH3-only protein knockout mice clarify the issue of ‘direct versus indirect’ activation of Bax and Bak? by Villunger, A, Labi, V, Bouillet, P, Adams, J, Strasser, A

Get full text