Search Results - "Villoslada, Pablo"

Personalized medicine for multiple sclerosis: How to integrate neurofilament light chain levels in the decision? by Villoslada, Pablo

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A Phase 1 randomized study on the safety and pharmacokinetics of OCS-05, a neuroprotective disease modifying treatment for Acute Optic Neuritis and Multiple Sclerosis by Villoslada, Pablo, Masso, Mar, Paris, Stephane, Hutchings, Simon, Koch, Annelize

“…OCS-05 (aka BN201) is a peptidomimetic that binds to serum glucocorticoid kinase-2 (SGK2), displaying neuroprotective activity. The objective of this…”
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The investigation of acute optic neuritis: a review and proposed protocol by Petzold, Axel, Wattjes, Mike P., Costello, Fiona, Flores-Rivera, Jose, Fraser, Clare L., Fujihara, Kazuo, Leavitt, Jacqueline, Marignier, Romain, Paul, Friedemann, Schippling, Sven, Sindic, Christian, Villoslada, Pablo, Weinshenker, Brian, Plant, Gordon T.

“…Key Points Optic neuritis is frequently but not always associated with multiple sclerosis (MS), and patients who present with optic neuritis will want to know…”
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Oxidative stress and proinflammatory cytokines contribute to demyelination and axonal damage in a cerebellar culture model of neuroinflammation by di Penta, Alessandra, Moreno, Beatriz, Reix, Stephanie, Fernandez-Diez, Begoña, Villanueva, Maite, Errea, Oihana, Escala, Nagore, Vandenbroeck, Koen, Comella, Joan X, Villoslada, Pablo

“…Demyelination and axonal damage are critical processes in the pathogenesis of multiple sclerosis (MS). Oxidative stress and pro-inflammatory cytokines elicited…”
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Regional grey matter microstructural changes and volume loss according to disease duration in multiple sclerosis patients by Solana, Elisabeth, Martinez-Heras, Eloy, Montal, Victor, Vilaplana, Eduard, Lopez-Soley, Elisabet, Radua, Joaquim, Sola-Valls, Nuria, Montejo, Carmen, Blanco, Yolanda, Pulido-Valdeolivas, Irene, Sepúlveda, Maria, Andorra, Magi, Berenguer, Joan, Villoslada, Pablo, Martinez-Lapiscina, E. H., Prados, Ferran, Saiz, Albert, Fortea, Juan, Llufriu, Sara

“…The spatio-temporal characteristics of grey matter (GM) impairment in multiple sclerosis (MS) are poorly understood. We used a new surface-based diffusion MRI…”
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Trans-synaptic axonal degeneration in the visual pathway in multiple sclerosis by Gabilondo, Iñigo, Martínez-Lapiscina, Elena H., Martínez-Heras, Eloy, Fraga-Pumar, Elena, Llufriu, Sara, Ortiz, Santiago, Bullich, Santiago, Sepulveda, Maria, Falcon, Carles, Berenguer, Joan, Saiz, Albert, Sanchez-Dalmau, Bernardo, Villoslada, Pablo

“…Objective To evaluate the association between the damage to the anterior and posterior visual pathway as evidence of the presence of retrograde and anterograde…”
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Tolerogenic Dendritic Cells as a Promising Antigen-Specific Therapy in the Treatment of Multiple Sclerosis and Neuromyelitis Optica From Preclinical to Clinical Trials by Flórez-Grau, Georgina, Zubizarreta, Irati, Cabezón, Raquel, Villoslada, Pablo, Benitez-Ribas, Daniel

“…The identification of activated T-lymphocytes restricted to myelin-derived immunogenic peptides in multiple sclerosis (MS) and aquaporin-4 water channel in…”
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Lesions in the posterior visual pathway promote trans-synaptic degeneration of retinal ganglion cells by Keller, Johannes, Sánchez-Dalmau, Bernardo F, Villoslada, Pablo

“…Retrograde trans-synaptic degeneration of retinal ganglion cell layer (GCL) has been proposed as one of the mechanisms contributing to permanent disability…”
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Randomized placebo-controlled phase II trial of autologous mesenchymal stem cells in multiple sclerosis by Llufriu, Sara, Sepúlveda, María, Blanco, Yolanda, Marín, Pedro, Moreno, Beatriz, Berenguer, Joan, Gabilondo, Iñigo, Martínez-Heras, Eloy, Sola-Valls, Nuria, Arnaiz, Joan-Albert, Andreu, Enrique J, Fernández, Begoña, Bullich, Santi, Sánchez-Dalmau, Bernardo, Graus, Francesc, Villoslada, Pablo, Saiz, Albert

“…Uncontrolled studies of mesenchymal stem cells (MSCs) in multiple sclerosis suggested some beneficial effect. In this randomized, double-blind,…”
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Increased expression of cystine/glutamate antiporter in multiple sclerosis by Pampliega, Olatz, Domercq, María, Soria, Federico N, Villoslada, Pablo, Rodríguez-Antigüedad, Alfredo, Matute, Carlos

“…Glutamate excitotoxicity contributes to oligodendrocyte and tissue damage in multiple sclerosis (MS). Intriguingly, glutamate level in plasma and cerebrospinal…”
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Retinal and brain damage during multiple sclerosis course: inflammatory activity is a key factor in the first 5 years by Pulido-Valdeolivas, Irene, Andorrà, Magí, Gómez-Andrés, David, Nakamura, Kunio, Alba-Arbalat, Salut, Lampert, Erika J., Zubizarreta, Irati, Llufriu, Sara, Martinez-Heras, Eloy, Solana, Elisabeth, Sola-Valls, Nuria, Sepulveda, María, Tercero-Uribe, Ana, Blanco, Yolanda, Camos-Carreras, Anna, Sanchez-Dalmau, Bernardo, Villoslada, Pablo, Saiz, Albert, Martinez-Lapiscina, Elena H.

“…Understanding of the role of focal inflammation, a treatable feature, on neuro-axonal injury, is paramount to optimize neuroprotective strategy in MS. To…”
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Burden of neurological diseases in the US revealed by web searches by Baeza-Yates, Ricardo, Sangal, Puneet Mohan, Villoslada, Pablo

“…Analyzing the disease-related web searches of Internet users provides insight into the interests of the general population as well as the healthcare industry,…”
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Structural networks involved in attention and executive functions in multiple sclerosis by Llufriu, Sara, Martinez-Heras, Eloy, Solana, Elisabeth, Sola-Valls, Nuria, Sepulveda, Maria, Blanco, Yolanda, Martinez-Lapiscina, Elena H, Andorra, Magi, Villoslada, Pablo, Prats-Galino, Alberto, Saiz, Albert

“…Attention and executive deficits are disabling symptoms in multiple sclerosis (MS) that have been related to disconnection mechanisms. We aimed to investigate…”
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The disruption of mitochondrial axonal transport is an early event in neuroinflammation by Errea, Oihana, Moreno, Beatriz, Gonzalez-Franquesa, Alba, Garcia-Roves, Pablo M, Villoslada, Pablo

“…In brain inflammatory diseases, axonal damage is one of the most critical steps in the cascade that leads to permanent disability. Thus, identifying the…”
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Diagnostic accuracy of retinal abnormalities in predicting disease activity in MS by SEPULCRE, Jorge, MURIE-FERNANDEZ, Manuel, SALINAS-ALAMAN, Angel, GARCIA-LAYANA, Alfredo, BEJARANO, Bartolome, VILLOSLADA, Pablo

“…To assess the association between the thickness of the retinal nerve fiber layer (RNFL), assessed by optical coherence tomography (OCT), retinal periphlebitis…”
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Symptomatic and restorative therapies in neuromyelitis optica spectrum disorders by Abboud, Hesham, Salazar-Camelo, Andrea, George, Naveen, Planchon, Sarah M., Matiello, Marcelo, Mealy, Maureen A., Goodman, Andrew

“…Neuromyelitis optica spectrum disorders (NMOSD) are a group of autoimmune inflammatory conditions that primarily target the optic nerves, spinal cord,…”
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Early retinal atrophy predicts long-term visual impairment after acute optic neuritis by Sanchez-Dalmau, Bernardo, Martinez-Lapiscina, Elena H, Torres-Torres, Ruben, Ortiz-Perez, Santiago, Zubizarreta, Irati, Pulido-Valdeolivas, Irene V, Alba-Arbalat, Salut, Guerrero-Zamora, Ana, Calbet, David, Villoslada, Pablo

“…Background: Visual recovery after optic neuritis (ON) used to be defined as good, although patients frequently complain of poor vision. Methods: We carried out…”
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Dynamics and heterogeneity of brain damage in multiple sclerosis by Kotelnikova, Ekaterina, Kiani, Narsis A, Abad, Elena, Martinez-Lapiscina, Elena H, Andorra, Magi, Zubizarreta, Irati, Pulido-Valdeolivas, Irene, Pertsovskaya, Inna, Alexopoulos, Leonidas G, Olsson, Tomas, Martin, Roland, Paul, Friedemann, Tegnér, Jesper, Garcia-Ojalvo, Jordi, Villoslada, Pablo

“…Multiple Sclerosis (MS) is an autoimmune disease driving inflammatory and degenerative processes that damage the central nervous system (CNS). However, it is…”
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Reclassifying neurodegenerative diseases by Villoslada, Pablo, Baeza-Yates, Ricardo, Masdeu, Joseph C.

“…Neuropathologies can be classified, on the basis of post-mortem histopathology and by using machine learning, into six transdiagnostic clusters associated with…”
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Predictors of vision impairment in Multiple Sclerosis by Sanchez-Dalmau, Bernardo, Martinez-Lapiscina, Elena H, Pulido-Valdeolivas, Irene, Zubizarreta, Irati, Llufriu, Sara, Blanco, Yolanda, Sola-Valls, Nuria, Sepulveda, Maria, Guerrero, Ana, Alba, Salut, Andorra, Magi, Camos, Anna, Sanchez-Vela, Laura, Alfonso, Veronica, Saiz, Albert, Villoslada, Pablo

“…Visual impairment significantly alters the quality of life of people with Multiple Sclerosis (MS). The objective of this study was to identify predictors…”
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