Relationship between serum levels of osteocalcin and atherosclerotic disease in type 2 diabetes

Abstract Aims To analyze the relationship between serum levels of osteocalcin and parameters of atherosclerosis in patients with type 2 diabetes mellitus (T2DM). Methods This cross-sectional study of 78 patients with T2DM evaluated intima–media thickness, and the prevalence of coronary heart disease...

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Published in:	Diabetes & metabolism Vol. 38; no. 1; pp. 76 - 81
Main Authors:	Reyes-Garcia, R, Rozas-Moreno, P, Jimenez-Moleon, J.J, Villoslada, M.J. Lara, Garcia-Salcedo, J.A, Santana-Morales, S, Muñoz-Torres, M
Format:	Journal Article
Language:	English
Published:	France Elsevier Masson SAS 01-02-2012
Subjects:	Atherosclerosis Atherosclerosis - blood Atherosclerosis - mortality Atherosclerosis - physiopathology Athérosclérose Biomarkers - blood Calcinosis - blood Calcinosis - mortality Calcinosis - physiopathology Carotid Arteries - physiopathology Cross-Sectional Studies Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - mortality Diabetes Mellitus, Type 2 - physiopathology Diabetic Angiopathies - blood Diabetic Angiopathies - mortality Diabetic Angiopathies - physiopathology Diabète de type 2 Endocrinology & Metabolism Female Glycated Hemoglobin A Humans Internal Medicine Male Middle Aged Osteocalcin Osteocalcin - blood Ostéocalcine Tunica Intima - physiopathology Type 2 diabetes Type 2 diabetes intima–media thickness striglycerides T2DM Osteocalcin baPWV endothelial precursors Ostéocalcine Athérosclérose IMT Diabète de type 2 TG OC Atherosclerosis coronary heart disease EPCS FPG fasting plasma glucose brachial–ankle pulse wave velocity CHD
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Summary:	Abstract Aims To analyze the relationship between serum levels of osteocalcin and parameters of atherosclerosis in patients with type 2 diabetes mellitus (T2DM). Methods This cross-sectional study of 78 patients with T2DM evaluated intima–media thickness, and the prevalence of coronary heart disease, atherosclerotic plaques and aortic calcifications. Serum osteocalcin levels were also determined by radioimmunoassay. Results The patients’ mean age was 57.8 ± 6.4 years (duration of diabetes: 13.4 years; mean HbA1c level: 8.01%), and 37.2% had coronary heart disease, 56% had an abnormal intima–media thickness, 26.9% had carotid plaques and 32.1% had aortic calcifications. Coronary heart disease was associated with higher levels of osteocalcin in male vs female patients (1.95 ± 1.36 vs 0.93 ± 0.86 ng/mL, respectively; P = 0.006). Also, higher concentrations of osteocalcin were found in female patients with vs without abnormal intima–media thicknesses (2.17 ± 1.84 vs 1.25 ± 0.67 ng/mL, respectively; P = 0.042), carotid plaques (2.86 ± 2.10 vs 1.43 ± 1.09 ng/mL, respectively; P = 0.03) and aortic calcifications (2.85 ± 1.97 vs 1.26 ± 0.83 ng/mL, respectively; P = 0.002). Serum osteocalcin levels were associated with coronary heart disease on multivariate logistic regression (odds ratio: 2.27, 95% confidence interval: 1.21–4.25; P = 0.01). Conclusion In T2DM patients, serum osteocalcin levels were associated with parameters of atherosclerosis, suggesting that osteocalcin is involved not only in bone metabolism, but also in atherosclerotic disease.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1262-3636 1878-1780
DOI:	10.1016/j.diabet.2011.07.008