Search Results - "Villey, I."

3β-Methoxypregnenolone, a pregnenolone analogue, enhances neurite outgrowth and neuronal plasticity in neuronal culture by Schverer, M, Leandri, J, Cottin, J, Villey, I, Lanfumey, L, Baulieu, E.E, Froger, N

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P.2.a.022 Robust efficacy of 3β-methoxy-pregnenolone (MAP4343) in validated animal models of depression suggests a new antidepressant mechanism by Froger, N, Parésys, L, Fournet, V, Ladurelle, N, Cottin, J, Leandri, J, Hoffmann, K, Fuchs, E, Bianchi, M, Villey, I, Baulieu, E.E

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The RAG Proteins and V(D)J Recombination: Complexes, Ends, and Transposition by Fugmann, Sebastian D, Lee, Alfred Ian, Shockett, Penny E, Villey, Isabelle J, Schatz, David G

“…V(D)J recombination proceeds through a series of protein:DNA complexes mediated in part by the RAG1 and RAG2 proteins. These proteins are responsible for…”
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Identification of Two Catalytic Residues in RAG1 that Define a Single Active Site within the RAG1/RAG2 Protein Complex by Fugmann, Sebastian D., Villey, Isabelle J., Ptaszek, Leon M., Schatz, David G.

“…During V(D)J recombination, the RAG1 and RAG2 proteins cooperate to catalyze a series of DNA bond breakage and strand transfer reactions. The structure,…”
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Detection of RAG Protein-V(D)J Recombination Signal Interactions Near the Site of DNA Cleavage by UV Cross-Linking by Eastman, Quinn M., Villey, Isabelle J., Schatz, David G.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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A dimer of the lymphoid protein RAG1 recognizes the recombination signal sequence and the complex stably incorporates the high mobility group protein HMG2 by Rodgers, Karla K., Villey, Isabelle J., Ptaszek, Leon, Corbett, Elizabeth, Schatz, David G., Coleman, Joseph E.

“…RAG1 and RAG2 are the two lymphoid-specific proteins required for the cleavage of DNA sequences known as the recombination signal sequences (RSSs) flanking V,…”
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P.1.023 - 3β-Methoxypregnenolone, a pregnenolone analogue, enhances neurite outgrowth and neuronal plasticity in neuronal culture by Schverer, M., Leandri, J., Cottin, J., Villey, I., Lanfumey, L., Baulieu, E.E., Froger, N.

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P.2.a.022 - 3β Methoxypregnenolone (MAP4343), a synthetic pregnenolone derivative, promotes neuronal and synaptic plasticity in vitro by Schverer, M., Leandri, J., Amazit, L., Heck, N., Artus, A., Villey, I., Lanfumey, L., Baulieu, E., Froger, N.

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3β Methoxypregnenolone (MAP4343), a synthetic pregnenolone derivative, promotes neuronal and synaptic plasticity in vitro by Schverer, M., Leandri, J., Amazit, L., Heck, N., Artus, A., Villey, I., Lanfumey, L., Baulieu, E., Froger, N.

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The metallo-beta-lactamase/beta-CASP domain of Artemis constitutes the catalytic core for V(D)J recombination by Poinsignon, Catherine, Moshous, Despina, Callebaut, Isabelle, de Chasseval, Régina, Villey, Isabelle, de Villartay, Jean-Pierre

“…The V(D)J recombination/DNA repair factor Artemis belongs to the metallo-beta-lactamase (beta-Lact) superfamily of enzymes. Three regions can be defined within…”
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Defect in Rearrangement of the Most 5′ TCR–Jα Following Targeted Deletion of T Early α (TEA): Implications for TCR α Locus Accessibility by Villey, Isabelle, Caillol, Danielle, Selz, Françoise, Ferrier, Pierre, de Villartay, Jean-Pierre

“…To address the role of the TEA germline transcription, which initiates upstream of the TCR–Jαs, in the regulation of TCR–Jα locus accessibility, we created a…”
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Defect in rearrangement of the most 5′TCR-jα following targeted deletion of T early α (tea): Implications for TCRα locus accessibility by Villey, I

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Germline transcription and methylation status of the TCR-Jα locus in its “accessible” configuration by Villey, I

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RORγT, a thymus‐specific isoform of the orphan nuclear receptor RORγ / TOR, is up‐regulated by signaling through the pre‐T cell receptor and binds to the TEA promoter by Villey, Isabelle, de Chasseval, Régina, de Villartay, Jean‐Pierre

“…TEA (T early alpha) is a genetic element located upstream of the TCR‐Jα cluster. Thymocytes from mice carrying a targeted deletion of TEA do not rearrange…”
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DNA-Rag protein interactions in the control of selective D gene utilization in the TCR beta locus by Olaru, Alexandru, Patterson, Dimeka N, Villey, Isabelle, Livák, Ferenc

“…Ordered assembly of Ag receptor genes by VDJ recombination is a key determinant of successful lymphocyte differentiation and function. Control of gene…”
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TEA regulates local TCR‐Jα accessibility through histone acetylation by Mauvieux, Laurent, Villey, Isabelle, de Villartay, Jean‐Pierre

“…Enhancer α‐dependent histone acetylation has been proposed as a molecular mechanism underlying the control of accessibility of recombination signal sequences…”
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Human and animal models of V(D)J recombination deficiency by de Villartay, Jean-Pierre, Poinsignon, Catherine, de Chasseval, Regina, Buck, Dietke, Le Guyader, Gwenaël, Villey, Isabelle

“…V(D)J recombination not only comprises the molecular mechanism that insures diversity of the immune system but also constitutes a critical checkpoint in the…”
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T early alpha (TEA) regulates initial TCRVAJA rearrangements and leads to TCRJA coincidence by Mauvieux, Laurent, Villey, Isabelle, de Villartay, Jean‐Pierre

“…Both TCRA alleles are rearranged in mature T lymphocytes, as a result of a lack of allelic exclusion at the TRCA locus. We show in a series of T cell clones…”
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RORgammaT, a thymus-specific isoform of the orphan nuclear receptor RORgamma / TOR, is up-regulated by signaling through the pre-T cell receptor and binds to the TEA promoter by Villey, I, de Chasseval, R, de Villartay, J P

“…TEA (T early alpha) is a genetic element located upstream of the TCR-Jalpha cluster. Thymocytes from mice carrying a targeted deletion of TEA do not rearrange…”
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Germ-line transcription and methylation status of the TCR-J alpha locus in its accessible configuration by Villey, I, Quartier, P, Selz, F, de Villartay, J P

“…We have generated two in vivo mouse models to study the regulation of DNA accessibility to the V(D)J recombinase machinery in the T cell receptor (TCR)-J alpha…”
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