Search Results - "Villela, Anne D"

Is IQG-607 a Potential Metallodrug or Metallopro-Drug With a Defined Molecular Target in Mycobacterium tuberculosis ? by Abbadi, Bruno L, Rodrigues-Junior, Valnês da Silva, Dadda, Adilio da Silva, Pissinate, Kenia, Villela, Anne D, Campos, Maria M, Lopes, Luiz G de França, Bizarro, Cristiano V, Machado, Pablo, Sousa, Eduardo H S, Basso, Luiz A

“…The emergence of strains of resistant to isoniazid (INH) has underscored the need for the development of new anti-tuberculosis agents. INH is activated by the…”
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Anti-tubercular profile of new selenium-menadione conjugates against Mycobacterium tuberculosis H37Rv (ATCC 27294) strain and multidrug-resistant clinical isolates by Ribeiro, Ruan C.B., de Marins, Daniel B., Di Leo, Iris, da Silva Gomes, Luana, de Moraes, Matheus G., Abbadi, Bruno L., Villela, Anne D., da Silva, Wellington F., da Silva, Luiz Cláudio R.P., Machado, Pablo, Bizarro, Cristiano Valim, Basso, Luiz Augusto, Cristina de Moraes, Marcela, Ferreira, Vitor F., da Silva, Fernando de C., Nascimento, Vanessa

“…Tuberculosis (TB) is one of the most fatal diseases and is responsible for the infection of millions of people around the world. Most recently, scientific…”
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Nonclinical evaluation of IQG-607, an anti-tuberculosis candidate with potential use in combination drug therapy by Rodrigues-Junior, Valnês S., Villela, Anne D., Abbadi, Bruno L., Sperotto, Nathalia D.M., Pissinate, Kenia, Picada, Jaqueline N., Bondan da Silva, Juliana, Bizarro, Cristiano V., Machado, Pablo, Basso, Luiz A.

“…New effective compounds to treat tuberculosis are urgently needed. IQG-607 is an orally active anti-tuberculosis drug candidate, with promising preliminary…”
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Revisiting Activation of and Mechanism of Resistance to Compound IQG-607 in Mycobacterium tuberculosis by Abbadi, Bruno L, Villela, Anne D, Rodrigues-Junior, Valnês S, Subtil, Fernanda T, Dalberto, Pedro F, Pinheiro, Ana P S, Santos, Diógenes S, Machado, Pablo, Basso, Luiz A, Bizarro, Cristiano V

“…IQG-607 is a metal complex previously reported as a promising anti-tuberculosis (TB) drug against isoniazid (INH)-resistant strains of Unexpectedly, we found…”
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Pre-clinical evaluation of quinoxaline-derived chalcones in tuberculosis by Muradás, Thaís C, Abbadi, Bruno L, Villela, Anne D, Macchi, Fernanda S, Bergo, Pedro F, de Freitas, Talita F, Sperotto, Nathalia D M, Timmers, Luis F S M, Norberto de Souza, Osmar, Picada, Jaqueline N, Fachini, Jean, da Silva, Juliana Bondan, de Albuquerque, Nayara C P, Habenschus, Maísa D, Carrão, Daniel B, Rocha, Bruno A, Barbosa Junior, Fernando, de Oliveira, Anderson R M, Mascarello, Alessandra, Neuenfeldf, Patrícia, Nunes, Ricardo J, Morbidoni, Héctor R, Campos, Maria M, Basso, Luiz A, Rodrigues-Junior, Valnês S

“…New effective compounds for tuberculosis treatment are needed. This study evaluated the effects of a series of quinoxaline-derived chalcones against…”
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Mefloquine and its oxazolidine derivative compound are active against drug-resistant Mycobacterium tuberculosis strains and in a murine model of tuberculosis infection by Rodrigues-Junior, Valnês S, Villela, Anne D, Gonçalves, Raoni S.B, Abbadi, Bruno Lopes, Trindade, Rogério Valim, López-Gavín, Alexandre, Tudó, Griselda, González-Martín, Julian, Basso, Luiz Augusto, de Souza, Marcus V.N, Campos, Maria Martha, Santos, Diógenes Santiago

“…Highlights • Mefloquine and its oxazolidine derivative 1E were active in a murine model of tuberculosis (TB). • Mefloquine and 1E were active after oral…”
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Functional, thermodynamics, structural and biological studies of in silico-identified inhibitors of Mycobacterium tuberculosis enoyl-ACP(CoA) reductase enzyme by Martinelli, Leonardo K. B., Rotta, Mariane, Villela, Anne D., Rodrigues-Junior, Valnês S., Abbadi, Bruno L., Trindade, Rogério V., Petersen, Guilherme O., Danesi, Giuliano M., Nery, Laura R., Pauli, Ivani, Campos, Maria M., Bonan, Carla D., de Souza, Osmar Norberto, Basso, Luiz A., Santos, Diogenes S.

“…Novel chemotherapeutics agents are needed to kill Mycobacterium tuberculosis , the main causative agent of tuberculosis (TB). The M. tuberculosis 2- tran…”
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IQG-607 abrogates the synthesis of mycolic acids and displays intracellular activity against Mycobacterium tuberculosis in infected macrophages by Rodrigues-Junior, Valnês S, dos Santos Junior, André A, Villela, Anne D, Belardinelli, Juan M, Morbidoni, Héctor R, Basso, Luiz A, Campos, Maria M, Santos, Diógenes S

“…Abstract In this work, the antitubercular activity of a pentacyano(isoniazid)ferrate(II) compound (IQG-607) was investigated using a macrophage model of…”
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Effect of the bradykinin 1 receptor antagonist SSR240612 after oral administration in Mycobacterium tuberculosis-infected mice by Rodrigues-Junior, Valnês S., Pail, Priscilla B., Villela, Anne D., Falcão, Virgínia C.A., Dadda, Adílio S., Abbadi, Bruno L., Pesquero, João B., Santos, Diógenes S., Basso, Luiz A., Campos, Maria M.

“…The role, if any, played by the kinin system in tuberculosis infection models, either in vivo or in vitro, was investigated. The effects of Mycobacterium…”
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Synthesis, Inhibition of Mycobacterium tuberculosis Enoyl-acyl Carrier Protein Reductase and Antimycobacterial Activity of Novel Pentacyanoferrate(II)-isonicotinoylhydrazones by Gazzi, Thais, Rotta, Mariane, Villela, Anne, Rodrigues-Junior, Valnês, Martinelli, Leonardo, Sales, Francisco, de Sousa, Eduardo, Campos, Maria, Basso, Luiz, Santos, Diógenes, Machado, Pablo

“…Tuberculosis remains among the top causes of death triggered by a single pathogen. Herein, a greener synthetic approach for isonicotinoylhydrazones is…”
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