Search Results - "Villegas, Núria"

Bioactivity descriptors for uncharacterized chemical compounds by Bertoni, Martino, Duran-Frigola, Miquel, Badia-i-Mompel, Pau, Pauls, Eduardo, Orozco-Ruiz, Modesto, Guitart-Pla, Oriol, Alcalde, Víctor, Diaz, Víctor M., Berenguer-Llergo, Antoni, Brun-Heath, Isabelle, Villegas, Núria, de Herreros, Antonio García, Aloy, Patrick

“…Chemical descriptors encode the physicochemical and structural properties of small molecules, and they are at the core of chemoinformatics. The broad release…”
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The Impact of the HydroxyMethylCytosine epigenetic signature on DNA structure and function by Battistini, Federica, Dans, Pablo D, Terrazas, Montserrat, Castellazzi, Chiara L, Portella, Guillem, Labrador, Mireia, Villegas, Núria, Brun-Heath, Isabelle, González, Carlos, Orozco, Modesto

“…We present a comprehensive, experimental and theoretical study of the impact of 5-hydroxymethylation of DNA cytosine. Using molecular dynamics, biophysical…”
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Bioactivity Profile Similarities to Expand the Repertoire of COVID-19 Drugs by Duran-Frigola, Miquel, Bertoni, Martino, Blanco, Roi, Martínez, Víctor, Pauls, Eduardo, Alcalde, Víctor, Turon, Gemma, Villegas, Núria, Fernández-Torras, Adrià, Pons, Carles, Mateo, Lídia, Guitart-Pla, Oriol, Badia-i-Mompel, Pau, Gimeno, Aleix, Soler, Nicolas, Brun-Heath, Isabelle, Zaragoza, Hugo, Aloy, Patrick

“…Until a vaccine becomes available, the current repertoire of drugs is our only therapeutic asset to fight the SARS-CoV-2 outbreak. Indeed, emergency clinical…”
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Efficient siRNA-peptide conjugation for specific targeted delivery into tumor cells by Gandioso, Albert, Massaguer, Anna, Villegas, Núria, Salvans, Cándida, Sánchez, Dani, Brun-Heath, Isabelle, Marchán, Vicente, Orozco, Modesto, Terrazas, Montserrat

“…Despite the broad applicability of the Huisgen cycloaddition reaction, the click functionalization of RNAs with peptides still remains a challenge. Here we…”
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Impact of DNA methylation on 3D genome structure by Buitrago, Diana, Labrador, Mireia, Arcon, Juan Pablo, Lema, Rafael, Flores, Oscar, Esteve-Codina, Anna, Blanc, Julie, Villegas, Nuria, Bellido, David, Gut, Marta, Dans, Pablo D., Heath, Simon C., Gut, Ivo G., Brun Heath, Isabelle, Orozco, Modesto

“…Determining the effect of DNA methylation on chromatin structure and function in higher organisms is challenging due to the extreme complexity of epigenetic…”
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Molecular basis of Arginine and Lysine DNA sequence-dependent thermo-stability modulation by Martin, Benjamin, Dans, Pablo D, Wieczór, Milosz, Villegas, Nuria, Brun-Heath, Isabelle, Battistini, Federica, Terrazas, Montserrat, Orozco, Modesto

“…We have used a variety of theoretical and experimental techniques to study the role of four basic amino acids-Arginine, Lysine, Ornithine and…”
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Can A Denaturant Stabilize DNA? Pyridine Reverses DNA Denaturation in Acidic pH by Portella, Guillem, Terrazas, Montserrat, Villegas, Núria, González, Carlos, Orozco, Modesto

“…The stability of DNA is highly dependent on the properties of the surrounding solvent, such as ionic strength, pH, and the presence of denaturants and…”
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An artificial DNAzyme RNA ligase shows a reaction mechanism resembling that of cellular polymerases by Aranda, Juan, Terrazas, Montserrat, Gómez, Hansel, Villegas, Núria, Orozco, Modesto

“…DNAzymes have become attractive due to their potential biomedical and biotechnological applications, as well as their advantages in terms of stability,…”
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Rational design of novel N-alkyl-N capped biostable RNA nanostructures for efficient long-term inhibition of gene expression by Terrazas, Montserrat, Ivani, Ivan, Villegas, Núria, Paris, Clément, Salvans, Cándida, Brun-Heath, Isabelle, Orozco, Modesto

“…Computational techniques have been used to design a novel class of RNA architecture with expected improved resistance to nuclease degradation, while showing…”
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The Impact of the HydroxyMethylCytosine epigenetic signature on DNA structure and function by Federica Battistini, Pablo D Dans, Montserrat Terrazas, Chiara L Castellazzi, Guillem Portella, Mireia Labrador, Núria Villegas, Isabelle Brun-Heath, Carlos González, Modesto Orozco

“…We present a comprehensive, experimental and theoretical study of the impact of 5-hydroxymethylation of DNA cytosine. Using molecular dynamics, biophysical…”
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Can A Denaturant Stabilize DNA? Pyridine Reverses DNA Denaturation in Acidic pH by Portella, Guillem, Terrazas, Montserrat, Villegas, Núria, González, Carlos, Orozco, Modesto

“…The stability of DNA is highly dependent on the properties of the surrounding solvent, such as ionic strength, pH, and the presence of denaturants and…”
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Controlled sulfur-based engineering confers mouldability to phosphorothioate antisense oligonucleotides by Genna, Vito, Iglesias-Fernández, Javier, Reyes-Fraile, Laura, Villegas, Nuria, Guckian, Kevin, Seth, Punit, Wan, Brad, Cabrero, Cristina, Terrazas, Montserrat, Brun-Heath, Isabelle, González, Carlos, Sciabola, Simone, Villalobos, Anabella, Orozco, Modesto

“…Abstract Phosphorothioates (PS) have proven their effectiveness in the area of therapeutic oligonucleotides with applications spanning from cancer treatment to…”
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