Search Results - "Villegas, José A"

Molecular and environmental determinants of biomolecular condensate formation by Villegas, José A., Heidenreich, Meta, Levy, Emmanuel D.

“…Biomolecular condensate formation has been implicated in a host of biological processes and has found relevance in biology and disease. Understanding the…”
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Infinite Assembly of Folded Proteins in Evolution, Disease, and Engineering by Garcia‐Seisdedos, Hector, Villegas, José A., Levy, Emmanuel D.

“…Mutations and changes in a protein's environment are well known for their potential to induce misfolding and aggregation, including amyloid formation…”
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A unified statistical potential reveals that amino acid stickiness governs nonspecific recruitment of client proteins into condensates by Villegas, José A., Levy, Emmanuel D.

“…Membraneless organelles are cellular compartments that form by liquid–liquid phase separation of one or more components. Other molecules, such as proteins and…”
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Binding sites in the epidermal growth factor receptor are responsible for bisphenol S effects on trophoblast cell invasion by Ticiani, Elvis, Villegas, José A., Murga-Zamalloa, Carlos, Veiga-Lopez, Almudena

“…Bisphenol S (BPS) is an endocrine disrupting chemical and the second most abundant bisphenol detected in humans. We have recently demonstrated that in utero…”
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IL-33 acts as a costimulatory signal to generate alloreactive Th1 cells in graft-versus-host disease by Dwyer, Gaelen K, Mathews, Lisa R, Villegas, José A, Lucas, Anna, Gonzalez de Peredo, Anne, Blazar, Bruce R, Girard, Jean-Philippe, Poholek, Amanda C, Luther, Sanjiv A, Shlomchik, Warren, Turnquist, Hēth R

“…Antigen-presenting cells (APCs) integrate signals emanating from local pathology and program appropriate T cell responses. In allogeneic hematopoietic stem…”
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Il-23/Th17 cell pathway: A promising target to alleviate thymic inflammation maintenance in myasthenia gravis by Villegas, José A., Bayer, Alexandra C., Ider, Katia, Bismuth, Jacky, Truffault, Frédérique, Roussin, Régine, Santelmo, Nicola, Le Panse, Rozen, Berrih-Aknin, Sonia, Dragin, Nadine

“…IL-23/Th17 pathway has been identified to sustain inflammatory condition in several autoimmune diseases and therefore being targeted in various therapeutic and…”
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Computational Design of Single-Peptide Nanocages with Nanoparticle Templating by Villegas, José A, Sinha, Nairiti J, Teramoto, Naozumi, Von Bargen, Christopher D, Pochan, Darrin J, Saven, Jeffery G

“…Protein complexes perform a diversity of functions in natural biological systems. While computational protein design has enabled the development of symmetric…”
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The alarmin interleukin-33 promotes the expansion and preserves the stemness of Tcf-1+ CD8+ T cells in chronic viral infection by Marx, Anna-Friederike, Kallert, Sandra M., Brunner, Tobias M., Villegas, José A., Geier, Florian, Fixemer, Jonas, Abreu-Mota, Tiago, Reuther, Peter, Bonilla, Weldy V., Fadejeva, Jelizaveta, Kreutzfeldt, Mario, Wagner, Ingrid, Aparicio-Domingo, Patricia, Scarpellino, Leo, Charmoy, Mélanie, Utzschneider, Daniel T., Hagedorn, Claudia, Lu, Min, Cornille, Karen, Stauffer, Karsten, Kreppel, Florian, Merkler, Doron, Zehn, Dietmar, Held, Werner, Luther, Sanjiv A., Löhning, Max, Pinschewer, Daniel D.

“…T cell factor 1 (Tcf-1) expressing CD8+ T cells exhibit stem-like self-renewing capacity, rendering them key for immune defense against chronic viral infection…”
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Improving target amino acid selectivity in a permissive aminoacyl tRNA synthetase through counter-selection by Sungwienwong, Itthipol, Hostetler, Zachary M, Blizzard, Robert J, Porter, Joseph J, Driggers, Camden M, Mbengi, Lea Z, Villegas, José A, Speight, Lee C, Saven, Jeffery G, Perona, John J, Kohli, Rahul M, Mehl, Ryan A, Petersson, E James

“…The amino acid acridon-2-ylalanine (Acd) can be a valuable probe of protein dynamics, either alone or as part of a Förster resonance energy transfer (FRET) or…”
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Blocking interleukin-23 ameliorates neuromuscular and thymic defects in myasthenia gravis by Villegas, José A, Van Wassenhove, Jérôme, Merrheim, Judith, Matta, Karen, Hamadache, Samy, Flaugère, Clémence, Pothin, Pauline, Truffault, Frédérique, Hascoët, Sébastien, Santelmo, Nicola, Alifano, Marco, Berrih-Aknin, Sonia, le Panse, Rozen, Dragin, Nadine

“…Acetylcholine receptor (AChR) myasthenia gravis (MG) is a chronic autoimmune disease characterized by muscle weakness. The AChR autoantibodies are produced by…”
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Mapping the energy landscape of PROTAC-mediated protein-protein interactions by Villegas, José A., Vaid, Tasneem M., Johnson, Michael E., Moore, Terry W.

“…A principal challenge in computational modeling of macromolecules is the vast conformational space that arises out of large numbers of atomic degrees of…”
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A protein–protein host–guest complex: Thermostable ferritin encapsulating positively supercharged green fluorescent protein by Pulsipher, Katherine W., Bulos, Joshua A., Villegas, José A., Saven, Jeffery G., Dmochowski, Ivan J.

“…We characterize the encapsulation of supercharged green fluorescent protein, GFP(+36), by thermophilic ferritin from Archaeoglobus fulgidus (AfFtn). The…”
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The isoquinoline PRL-295 increases the thermostability of Keap1 and disrupts its interaction with Nrf2 by Dayalan Naidu, Sharadha, Suzuki, Takafumi, Dikovskaya, Dina, Knatko, Elena V., Higgins, Maureen, Sato, Miu, Novak, Miroslav, Villegas, José A., Moore, Terry W., Yamamoto, Masayuki, Dinkova-Kostova, Albena T.

“…Transcription factor Nrf2 and its negative regulator Keap1 orchestrate a cytoprotective response against oxidative, metabolic, and inflammatory stress. Keap1…”
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GATA-3 is a proto-oncogene in T-cell lymphoproliferative neoplasms by Geng, Xiangrong, Wang, Chenguang, Gao, Xin, Chowdhury, Pinki, Weiss, Jonathan, Villegas, José A., Saed, Badeia, Perera, Thilini, Hu, Ying, Reneau, John, Sverdlov, Maria, Wolfe, Ashley, Brown, Noah, Harms, Paul, Bailey, Nathanael G., Inamdar, Kedar, Hristov, Alexandra C., Tejasvi, Trilokraj, Montes, Jaime, Barrionuevo, Carlos, Taxa, Luis, Casavilca, Sandro, de Pádua Covas Lage, J. Luís Alberto, Culler, Hebert Fabrício, Pereira, Juliana, Runge, John S., Qin, Tingting, Tsoi, Lam C., Hong, Hanna S., Zhang, Li, Lyssiotis, Costas A., Ohe, Rintaro, Toubai, Tomomi, Zevallos-Morales, Alejandro, Murga-Zamalloa, Carlos, Wilcox, Ryan A.

“…Neoplasms originating from thymic T-cell progenitors and post-thymic mature T-cell subsets account for a minority of lymphoproliferative neoplasms. These…”
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Multi-Tone Optical Source Generation for Applications in Next-Generation Passive Optical Networks using Photonic Structures by Jaramillo Villegas, José Alfredo, Guerrero González, Neil, Calvo Salcedo, Andrés Felipe

“…This study presents the design and simulation of an integrated multi-carrier optical source with a 227 GHz bandwidth for passive optical network (PON)…”
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Comparative study of the oral absorption of microencapsulated ferric saccharate and ferrous sulfate in humans by Contreras, Carlos, Barnuevo, María Dolores, Guillén, Isabel, Luque, Antonio, Lázaro, Elisabet, Espadaler, Jordi, López-Román, Javier, Villegas, José A

“…PURPOSE: Our objective was to compare the absorption of microencapsulated ferric saccharate (MFS) and ferrous sulfate (FS) in a fortified milk product, using a…”
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DHA- Rich Fish Oil Improves Complex Reaction Time in Female Elite Soccer Players by Guzmán, José F, Esteve, Hector, Pablos, Carlos, Pablos, Ana, Blasco, Cristina, Villegas, José A

“…Omega-3 fatty acids (n-3) has shown to improve neuromotor function. This study examined the effects of docosahexaenoic acid (DHA) on complex reaction time,…”
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Come for the atmosphere, stay for the interactions: Deciphering small molecule partitioning into biomolecular condensates by Sepehri, Bakhtyar, Drew, Kevin, Villegas, José A

“…Optimizing pharmacokinetic properties remains challenging but is generally guided by a set of structural rules. However, no such rule set exists for…”
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50-GHz-spaced comb of high-dimensional frequency-bin entangled photons from an on-chip silicon nitride microresonator by Imany, Poolad, Jaramillo-Villegas, Jose A, Odele, Ogaga D, Han, Kyunghun, Leaird, Daniel E, Lukens, Joseph M, Lougovski, Pavel, Qi, Minghao, Weiner, Andrew M

“…Quantum frequency combs from chip-scale integrated sources are promising candidates for scalable and robust quantum information processing (QIP). However, to…”
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Dispersion engineering and frequency comb generation in thin silicon nitride concentric microresonators by Kim, Sangsik, Han, Kyunghun, Wang, Cong, Jaramillo-Villegas, Jose A., Xue, Xiaoxiao, Bao, Chengying, Xuan, Yi, Leaird, Daniel E., Weiner, Andrew M., Qi, Minghao

“…Kerr nonlinearity-based frequency combs and solitons have been generated from on-chip microresonators. The initiation of the combs requires global or local…”
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