Search Results - "Villedieu, Marie"

The mTORC1/2 Inhibitor AZD8055 Strengthens the Efficiency of the MEK Inhibitor Trametinib to Reduce the Mcl-1/[Bim and Puma] ratio and to Sensitize Ovarian Carcinoma Cells to ABT-737 by Pétigny-Lechartier, Cécile, Duboc, Charlène, Jebahi, Abdelghani, Louis, Marie-Hélène, Abeilard, Edwige, Denoyelle, Christophe, Gauduchon, Pascal, Poulain, Laurent, Villedieu, Marie

“…The identification of novel therapeutic strategies is an important urgent requirement for the clinical management of ovarian cancer, which remains the leading…”
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Comparative analysis of response to treatments and molecular features of tumor-derived organoids versus cell lines and PDX derived from the same ovarian clear cell carcinoma by Thorel, Lucie, Morice, Pierre-Marie, Paysant, Hippolyte, Florent, Romane, Babin, Guillaume, Thomine, Cécilia, Perréard, Marion, Abeilard, Edwige, Giffard, Florence, Brotin, Emilie, Denoyelle, Christophe, Villenet, Céline, Sebda, Shéhérazade, Briand, Mélanie, Joly, Florence, Dolivet, Enora, Goux, Didier, Blanc-Fournier, Cécile, Jeanne, Corinne, Villedieu, Marie, Meryet-Figuiere, Matthieu, Figeac, Martin, Poulain, Laurent, Weiswald, Louis-Bastien

“…Background In the era of personalized medicine, the establishment of preclinical models of cancer that faithfully recapitulate original tumors is essential to…”
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Effect of 2-Deoxy-D-glucose on Various Malignant Cell Lines In Vitro by XIAO DONG ZHANG, DESLANDES, Edwige, VILLEDIEU, Marie, POULAIN, Laurent, DUVAL, Marilyne, GAUDUCHON, Pascal, SCHWARTZ, Laurent, ICARD, Philippe

“…Background: 2-Deoxy-D-glucose (2-DG) is an analog of glucose that is preferentially captured by tumors and is accumulated in transformed cells, because the…”
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ZNF217 confers resistance to the pro-apoptotic signals of paclitaxel and aberrant expression of Aurora-A in breast cancer cells by Thollet, Aurélie, Vendrell, Julie A, Payen, Léa, Ghayad, Sandra E, Ben Larbi, Sabrina, Grisard, Evelyne, Collins, Colin, Villedieu, Marie, Cohen, Pascale A

“…ZNF217 is a candidate oncogene located at 20q13, a chromosomal region frequently amplified in breast cancers. The precise mechanisms involved in ZNF217…”
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MicroRNA-125b upregulation confers aromatase inhibitor resistance and is a novel marker of poor prognosis in breast cancer by Vilquin, Paul, Donini, Caterina F, Villedieu, Marie, Grisard, Evelyne, Corbo, Laura, Bachelot, Thomas, Vendrell, Julie A, Cohen, Pascale A

“…Increasing evidence indicates that microRNAs (miRNAs) are important players in oncogenesis. Considering the widespread use of aromatase inhibitors (AIs) in…”
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Abstract 1921: The sensitivity of ovarian cancer cells to the HDAC inhibitor belinostat is improved by inhibiting Bcl-xL or Mcl-1 anti-apoptotic proteins by Duboc, Charlène, Abeilard, Edwige, Voisin-Chiret, Anne Sophie, Gauduchon, Pascal, Poulain, Laurent, Villedieu, Marie

“…The identification of novel therapeutic strategies is an important urgent requirement for the clinical management of ovarian cancers, which remain the leading…”
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PI3K/mTOR dual inhibitor NVP-BEZ235 decreases Mcl-1 expression and sensitizes ovarian carcinoma cells to Bcl-xL -targeting strategies, provided that Bim expression is induced by Jebahi, Abdelghani, Villedieu, Marie, Pétigny-Lechartier, Cécile, Brotin, Emilie, Louis, Marie-Hélène, Abeilard, Edwige, Giffard, Florence, Guercio, Marika, Briand, Mélanie, Gauduchon, Pascal, Lheureux, Stéphanie, Poulain, Laurent

“…Abstract We previously showed that Bcl-xL and Mcl-1 cooperatively protect platinum-resistant ovarian cancer cells from apoptosis. Here we assessed the…”
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Bcl‐XL and MCL‐1 constitute pertinent targets in ovarian carcinoma and their concomitant inhibition is sufficient to induce apoptosis by Brotin, Emilie, Meryet‐Figuière, Matthieu, Simonin, Karin, Duval, Raphaël E., Villedieu, Marie, Leroy‐Dudal, Johanne, Saison‐Behmoaras, Ester, Gauduchon, Pascal, Denoyelle, Christophe, Poulain, Laurent

“…In ovarian carcinomas, recurrence and acquired chemoresistance are the first leading causes of therapeutic failure and are responsible for the poor overall…”
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Molecular characterization of anastrozole resistance in breast cancer: Pivotal role of the Akt/mTOR pathway in the emergence of de novo or acquired resistance and importance of combining the allosteric Akt inhibitor MK‐2206 with an aromatase inhibitor by Vilquin, Paul, Villedieu, Marie, Grisard, Evelyne, Larbi, Sabrina Ben, Ghayad, Sandra E., Heudel, Pierre‐Etienne, Bachelot, Thomas, Corbo, Laura, Treilleux, Isabelle, Vendrell, Julie A., Cohen, Pascale A.

“…Acquisition of resistance to aromatase inhibitors (AIs) remains a major drawback in the treatment of estrogen receptor alpha (ERα)‐positive breast cancers. The…”
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Abstract 166: Comparative analysis of response to treatments and molecular features of patient-derived tumor organoids versus cell lines and PDX derived from the same ovarian clear cell carcinoma by Thorel, Lucie, Morice, Pierre-Marie, Paysant, Hippolyte, Florent, Romane, Babin, Guillaume, Thomine, Cecilia, Perreard, Marion, Abeilard, Edwige, Giffard, Florence, Brotin, Emilie, Denoyelle, Christophe, Villenet, Celine, Briand, Melanie, Leconte, Alexandra, Joly, Florence, Dolivet, Enora, Goux, Didier, Blanc-Fournier, Cecile, Jeanne, Corinne, Villedieu, Marie, Meryet-Figuiere, Matthieu, Figeac, Martin, Poulain, Laurent, Weiswald, Louis-Bastien

“…Preclinical models of cancer are essential for understanding cancer biology and developing effective cancer therapeutics, and potentially to guide clinical…”
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Bcl‐ X L and MCL‐1 constitute pertinent targets in ovarian carcinoma and their concomitant inhibition is sufficient to induce apoptosis by Brotin, Emilie, Meryet‐Figuière, Matthieu, Simonin, Karin, Duval, Raphaël E., Villedieu, Marie, Leroy‐Dudal, Johanne, Saison‐Behmoaras, Ester, Gauduchon, Pascal, Denoyelle, Christophe, Poulain, Laurent

“…In ovarian carcinomas, recurrence and acquired chemoresistance are the first leading causes of therapeutic failure and are responsible for the poor overall…”
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113: ZNF-X conferred increased cell proliferation and resistance to the pro-apoptotic action of paclitaxel in breast cancer cells by Aurélie, Thollet, Vendrell, Julie, Payen, Léa, Ghayad, Sandra, Ben Larbi, Sabrina, Villedieu, Marie, Cohen, Pascale

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Selected Writings of Madame de Villedieu by Shaw, David

“…"Selected Writings of Madame de Villedieu" edited by Nancy Deighton Klein is reviewed…”
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