Senescence-regulatory factors as novel circulating biomarkers and therapeutic targets in regenerative medicine for osteoarthritis

[Display omitted] •OA is characterized by a progressive loss of tissue homeostasis due to senescent cell accumulation within the joints and bones.•Circulating proteomic, metabolic factors, as well as microRNAs, could affect both senescence and osteoarticular tissue homeostasis leading to OA developm...

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Published in:	Joint, bone, spine : revue du rhumatisme Vol. 91; no. 2; p. 105640
Main Authors:	Maroun, Georges, Fissoun, Christina, Villaverde, Marina, Brondello, Jean-Marc, Pers, Yves-Marie
Format:	Journal Article
Language:	English
Published:	France Elsevier Masson SAS 01-03-2024
Subjects:	Biomarkers Osteoarthritis (OA) Oxidative stress and microRNAs (miRNA) Senescence Synovial fluid (SF) Systemic plasma factors Therapeutics Systemic plasma factors Senescence Synovial fluid (SF) Therapeutics Biomarkers Osteoarthritis (OA) Oxidative stress and microRNAs (miRNA)
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Summary:	[Display omitted] •OA is characterized by a progressive loss of tissue homeostasis due to senescent cell accumulation within the joints and bones.•Circulating proteomic, metabolic factors, as well as microRNAs, could affect both senescence and osteoarticular tissue homeostasis leading to OA development.•Some factors might be protective (GDF-11, alpha Klotho) or detrimental (GREM1, ROS, Chi3L1, miR-34a) regarding joint or bone tissue. Recent discoveries reveal that the chronic presence of senescent cells in osteoarticular tissues provides a focal point of disease development for osteoarthritis (OA). Nevertheless, senescence-regulatory factors associated with OA still need to be identified. Furthermore, few diagnostic- and prognostic-validated biochemical markers (biomarkers) are currently used in clinics to evaluate OA patients. In the future, alongside imaging and clinical examination, detecting senescence-regulatory biomarkers in patient fluids could become a prospective method for disease: diagnosis, monitoring, progression and prognosis following treatment. This review summarizes a group of circulating OA biomarkers recently linked to senescence onset. Remarkably, these factors identified in proteomics, metabolomic and microRNA studies could also have deleterious or protective roles in osteoarticular tissue homeostasis. In addition, we discuss their potentially innovative modulation in combination with senotherapeutic approaches, for long-lasting OA treatment.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	1297-319X 1778-7254 1778-7254
DOI:	10.1016/j.jbspin.2023.105640