Search Results - "Villarino, Alejandro V"

Mechanisms of Jak/STAT signaling in immunity and disease by Villarino, Alejandro V, Kanno, Yuka, Ferdinand, John R, O'Shea, John J

“…More than two decades ago, experiments on the antiviral mechanisms of IFNs led to the discovery of JAKs and their downstream effectors, the STAT proteins. This…”
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The JAK-STAT Pathway: Impact on Human Disease and Therapeutic Intervention by O'Shea, John J, Schwartz, Daniella M, Villarino, Alejandro V, Gadina, Massimo, McInnes, Iain B, Laurence, Arian

“…The Janus kinase (JAK)-signal transducer of activators of transcription (STAT) pathway is now recognized as an evolutionarily conserved signaling pathway…”
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Posttranscriptional Control of T Cell Effector Function by Aerobic Glycolysis by Chang, Chih-Hao, Curtis, Jonathan D., Maggi, Leonard B., Faubert, Brandon, Villarino, Alejandro V., O’Sullivan, David, Huang, Stanley Ching-Cheng, van der Windt, Gerritje J.W., Blagih, Julianna, Qiu, Jing, Weber, Jason D., Pearce, Edward J., Jones, Russell G., Pearce, Erika L.

“…A “switch” from oxidative phosphorylation (OXPHOS) to aerobic glycolysis is a hallmark of T cell activation and is thought to be required to meet the metabolic…”
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Asymmetric Action of STAT Transcription Factors Drives Transcriptional Outputs and Cytokine Specificity by Hirahara, Kiyoshi, Onodera, Atsushi, Villarino, Alejandro V., Bonelli, Michael, Sciumè, Giuseppe, Laurence, Arian, Sun, Hong-Wei, Brooks, Stephen R., Vahedi, Golnaz, Shih, Han-Yu, Gutierrez-Cruz, Gustavo, Iwata, Shigeru, Suzuki, Ryo, Mikami, Yohei, Okamoto, Yoshitaka, Nakayama, Toshinori, Holland, Steven M., Hunter, Christopher A., Kanno, Yuka, O’Shea, John J.

“…Interleukin-6 (IL-6) and IL-27 signal through a shared receptor subunit and employ the same downstream STAT transcription proteins, but yet are ascribed unique…”
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Non-classical Immunity Controls Microbiota Impact on Skin Immunity and Tissue Repair by Linehan, Jonathan L., Harrison, Oliver J., Han, Seong-Ji, Byrd, Allyson L., Vujkovic-Cvijin, Ivan, Villarino, Alejandro V., Sen, Shurjo K., Shaik, Jahangheer, Smelkinson, Margery, Tamoutounour, Samira, Collins, Nicholas, Bouladoux, Nicolas, Dzutsev, Amiran, Rosshart, Stephan P., Arbuckle, Jesse H., Wang, Chyung-Ru, Kristie, Thomas M., Rehermann, Barbara, Trinchieri, Giorgio, Brenchley, Jason M., O’Shea, John J., Belkaid, Yasmine

“…Mammalian barrier surfaces are constitutively colonized by numerous microorganisms. We explored how the microbiota was sensed by the immune system and the…”
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Subset- and tissue-defined STAT5 thresholds control homeostasis and function of innate lymphoid cells by Villarino, Alejandro V, Sciumè, Giuseppe, Davis, Fred P, Iwata, Shigeru, Zitti, Beatrice, Robinson, Gertraud W, Hennighausen, Lothar, Kanno, Yuka, O'Shea, John J

“…Innate lymphoid cells (ILCs) patrol environmental interfaces to defend against infection and protect barrier integrity. Using a genetic tuning model, we…”
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Rapid Enhancer Remodeling and Transcription Factor Repurposing Enable High Magnitude Gene Induction upon Acute Activation of NK Cells by Sciumè, Giuseppe, Mikami, Yohei, Jankovic, Dragana, Nagashima, Hiroyuki, Villarino, Alejandro V., Morrison, Tasha, Yao, Chen, Signorella, Sadie, Sun, Hong-Wei, Brooks, Stephen R., Fang, Difeng, Sartorelli, Vittorio, Nakayamada, Shingo, Hirahara, Kiyoshi, Zitti, Beatrice, Davis, Fred P., Kanno, Yuka, O’Shea, John J., Shih, Han-Yu

“…Innate immune responses rely on rapid and precise gene regulation mediated by accessibility of regulatory regions to transcription factors (TFs). In natural…”
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Divergent Role for STAT5 in the Adaptive Responses of Natural Killer Cells by Wiedemann, Gabriela M., Grassmann, Simon, Lau, Colleen M., Rapp, Moritz, Villarino, Alejandro V., Friedrich, Christin, Gasteiger, Georg, O’Shea, John J., Sun, Joseph C.

“…Natural killer (NK) cells are innate lymphocytes with the capacity to elicit adaptive features, including clonal expansion and immunological memory. Because…”
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MicroRNA-29a attenuates CD8 T cell exhaustion and induces memory-like CD8 T cells during chronic infection by Stelekati, Erietta, Cai, Zhangying, Manne, Sasikanth, Chen, Zeyu, Beltra, Jean-Christophe, Buchness, Lance Alec, Leng, Xuebing, Ristin, Svetlana, Nzingha, Kito, Ekshyyan, Viktoriya, Niavi, Christina, Abdel-Hakeem, Mohamed S, Ali, Mohammed-Alkhatim, Drury, Sydney, Lau, Chi Wai, Gao, Zhen, Ban, Yuguang, Zhou, Simon K, Ansel, K Mark, Kurachi, Makoto, Jordan, Martha S, Villarino, Alejandro V, Ngiow, Shin Foong, Wherry, E John

“…CD8 T cells mediate protection against intracellular pathogens and tumors. However, persistent antigen during chronic infections or cancer leads to T cell…”
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A mouse model of HIES reveals pro- and anti-inflammatory functions of STAT3 by Steward-Tharp, Scott M., Laurence, Arian, Kanno, Yuka, Kotlyar, Alex, Villarino, Alejandro V., Sciume, Giuseppe, Kuchen, Stefan, Resch, Wolfgang, Wohlfert, Elizabeth A., Jiang, Kan, Hirahara, Kiyoshi, Vahedi, Golnaz, Sun, Hong-wei, Feigenbaum, Lionel, Milner, Joshua D., Holland, Steven M., Casellas, Rafael, Powrie, Fiona, O'Shea, John J.

“…Mutations of STAT3 underlie the autosomal dominant form of hyperimmunoglobulin E syndrome (HIES). STAT3 has critical roles in immune cells and thus,…”
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T cell intrinsic STAT1 signaling prevents aberrant Th1 responses during acute toxoplasmosis by Schultz, Aaron B, Kugler, David G, Nivelo, Luis, Vitari, Nicolas, Doyle, Laura P, Ristin, Svetlana, Hennighausen, Lothar, O'Shea, John J, Jankovic, Dragana, Villarino, Alejandro V

“…Infection-induced T cell responses must be properly tempered and terminated to prevent immuno-pathology. Using transgenic mice, we demonstrate that T cell…”
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Smoking induces WEE1 expression to promote docetaxel resistance in esophageal adenocarcinoma by Islam, Md Obaidul, Thangaretnam, Krishnapriya, Lu, Heng, Peng, Dunfa, Soutto, Mohammed, El-Rifai, Wael, Giordano, Silvia, Ban, Yuguang, Chen, Xi, Bilbao, Daniel, Villarino, Alejandro V., Schürer, Stephan, Hosein, Peter J., Chen, Zheng

“…Esophageal adenocarcinoma (EAC) patients have poor clinical outcomes, with an overall 5-year survival rate of 20%. Smoking is a significant risk factor for…”
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IL-23 and IL-2 activation of STAT5 is required for optimal IL-22 production in ILC3s during colitis by Bauché, David, Joyce-Shaikh, Barbara, Fong, Julie, Villarino, Alejandro V, Ku, Karin S, Jain, Renu, Lee, Yu-Chi, Annamalai, Lakshmanan, Yearley, Jennifer H, Cua, Daniel J

“…Signal transducer and activator of transcription (STAT) proteins have critical roles in the development and function of immune cells. STAT signaling is often…”
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Understanding the Pro- and Anti-Inflammatory Properties of IL-27 by Villarino, Alejandro V, Huang, Elaine, Hunter, Christopher A

“…The recent identification of IL-27 (IL-27p28/EBV-induced gene 3) and IL-27R (WSX-1/gp130) has provided new insights for the biology of IL-6/IL-12 family…”
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Transcriptional programing of T cell metabolism by STAT family transcription factors by Villarino, Alejandro V.

“…T cells adapt their metabolism to meet the energetic and biosynthetic demands imposed by changes in location, behavior, and/or differentiation state. Many of…”
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IL-27 Limits IL-2 Production during Th1 Differentiation by Villarino, Alejandro V, Stumhofer, Jason S, Saris, Christiaan J. M, Kastelein, Robert A, de Sauvage, Frederic J, Hunter, Christopher A

“…Although the ability of IL-27 to promote T cell responses is well documented, the anti-inflammatory properties of this cytokine remain poorly understood. The…”
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Duration of antigen receptor signaling determines T-cell tolerance or activation by Katzman, Shoshana D., O’Gorman, William E., Villarino, Alejandro V., Gallo, Eugenio, Friedman, Rachel S., Krummel, Matthew F., Nolan, Garry P., Abbas, Abul K., Weiss, Arthur

“…The early events that determine the decision between lymphocyte tolerance and activation are not well-understood. Using a model of systemic self-antigen…”
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T Helper Plasticity Is Orchestrated by STAT3, Bcl6, and Blimp-1 Balancing Pathology and Protection in Malaria by Carpio, Victor H., Aussenac, Florentin, Puebla-Clark, Lucinda, Wilson, Kyle D., Villarino, Alejandro V., Dent, Alexander L., Stephens, Robin

“…Hybrid Th1/Tfh cells (IFN-γ+IL-21+CXCR5+) predominate in response to several persistent infections. In Plasmodium chabaudi infection, IFN-γ+ T cells control…”
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SnapShot: Jak-STAT Signaling II by Villarino, Alejandro V., Gadina, Massimo, O’Shea, John J., Kanno, Yuka

“…The JAK-STAT pathway is an evolutionarily conserved signal transduction paradigm, providing mechanisms for rapid receptor-to-nucleus communication and…”
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IL-27R deficiency delays the onset of colitis and protects from helminth-induced pathology in a model of chronic IBD by Villarino, Alejandro V., Artis, David, Bezbradica, Jelena S., Miller, Omer, Saris, Christiaan J. M., Joyce, Sebastian, Hunter, Christopher A.

“…Members of the IL-6/IL-12 cytokine family play central roles in Crohn's disease. The present findings demonstrate that IL-27, a close relative of IL-12 and…”
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