Search Results - "Villard, Frederic"

An allosteric MALT1 inhibitor is a molecular corrector rescuing function in an immunodeficient patient by Quancard, Jean, Klein, Theo, Fung, Shan-Yu, Renatus, Martin, Hughes, Nicola, Israël, Laura, Priatel, John J., Kang, Sohyeong, Blank, Michael A., Viner, Rosa I., Blank, Jutta, Schlapbach, Achim, Erbel, Paul, Kizhakkedathu, Jayachandran, Villard, Frédéric, Hersperger, René, Turvey, Stuart E., Eder, Joerg, Bornancin, Frédéric, Overall, Christopher M.

“…MALT1 paracaspase is central for lymphocyte antigen-dependent responses including NF-κB activation. We discovered nanomolar, selective allosteric inhibitors of…”
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An Orthogonal Collocation Method for Static and Dynamic Cosserat Rods by Jilani, Radhouane, Villard, Pierre-Frederic, Kerrien, Erwan

“…We propose an orthogonal collocation method (CM) for solving Cosserat rod Dirichlet-Neumann boundary value problems in static and dynamic modes. We interpolate…”
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Identification of FAM181A and FAM181B as new interactors with the TEAD transcription factors by Bokhovchuk, Fedir, Mesrouze, Yannick, Delaunay, Clara, Martin, Typhaine, Villard, Frédéric, Meyerhofer, Marco, Fontana, Patrizia, Zimmermann, Catherine, Erdmann, Dirk, Furet, Pascal, Scheufler, Clemens, Schmelzle, Tobias, Chène, Patrick

“…The Hippo pathway is a key signaling pathway in the control of organ size and development. The most distal elements of this pathway, the TEAD transcription…”
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Fast image‐based mitral valve simulation from individualized geometry by Clive, Loughlin, Villard, Pierre‐Frederic, Hammer, Peter E., Perrin, Douglas P., Nido, Pedro J., Howe, Robert D.

“…Background: Common surgical procedures on the mitral valve of the heart include modifications to the chordae tendineae. Such interventions are used when there…”
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An automated microseed matrix-screening method for protein crystallization by D'Arcy, Allan, Villard, Frederic, Marsh, May

“…A microseed‐matrix procedure has been established with the aim of influencing the nucleation event in standard crystallization screens. The method is based on…”
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macrocyclic HCV NS3/4A protease inhibitor interacts with protease and helicase residues in the complex with its full-length target by Schiering, Nikolaus, D’Arcy, Allan, Villard, Frederic, Simić, Oliver, Kamke, Marion, Monnet, Gaby, Hassiepen, Ulrich, Svergun, Dmitri I, Pulfer, Ruth, Eder, Jörg, Raman, Prakash, Bodendorf, Ursula

“…Hepatitis C virus (HCV) infection is a global health burden with over 170 million people infected worldwide. In a significant portion of patients chronic…”
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Stabilizing Inactive Conformations of MALT1 as an Effective Approach to Inhibit Its Protease Activity by Hughes, Nicola, Erbel, Paul, Bornancin, Frédéric, Wiesmann, Christian, Schiering, Nikolaus, Villard, Frédéric, Decock, Arnaud, Rubi, Bertran, Melkko, Samu, Spanka, Carsten, Buschmann, Nicole, Pissot‐Soldermann, Carole, Simic, Oliver, Beerli, René, Sorge, Mickael, Tintelnot‐Blomley, Marina, Beltz, Karen, Régnier, Catherine H., Quancard, Jean, Schlapbach, Achim, Langlois, Jean‐Baptiste, Renatus, Martin

“…The paracaspase MALT1 (mucosa associated lymphoid tissue lymphoma translocated gene 1) plays an important role in various immune pathways and is proposed as a…”
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Structure-function relationships with spectral-domain optical coherence tomography retinal nerve fiber layer and optic nerve head measurements by Pollet-Villard, Frédéric, Chiquet, Christophe, Romanet, Jean-Paul, Noel, Christian, Aptel, Florent

“…To evaluate the regional structure-function relationship between visual field sensitivity and retinal nerve fiber layer (RNFL) thickness and optic nerve head…”
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Toward a realistic simulation of organ dissection by Villard, Pierre-Frederic, Koenig, Nicolas, Perrenot, Cyril, Perez, Manuela, Boshier, Piers

“…Whilst laparoscopic surgical simulators are becoming increasingly realistic they can not, as yet, fully replicate the experience of live surgery. In particular…”
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N‐terminal β‐strand in YAP is critical for stronger binding to scalloped relative to TEAD transcription factor by Fedir, Bokhovchuk, Yannick, Mesrouze, Marco, Meyerhofer, Patrizia, Fontana, Catherine, Zimmermann, Frédéric, Villard, Dirk, Erdmann, Joerg, Kallen, Clemens, Scheufler, Camilo, Velez‐Vega, Patrick, Chène

“…The yes‐associated protein (YAP) regulates the transcriptional activity of the TEAD transcription factors that are key in the control of organ morphogenesis…”
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Capturing contact in mitral valve dynamic closure with fluid-structure interaction simulation by Khaledian, Nariman, Villard, Pierre-Frédéric, Berger, Marie-Odile

“…Purpose Realistic fluid-structure interaction (FSI) simulation of the mitral valve opens the way toward planning for surgical repair. In the literature, blood…”
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Open surgery simulation of inguinal hernia repair by Hald, Niels, Sarker, Sudip K, Ziprin, Paul, Villard, Pierre-Frederic, Bello, Fernando

“…Inguinal hernia repair procedures are often one of the first surgical procedures faced by junior surgeons. The biggest challenge in this procedure for novice…”
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Microfluidics Platform for Polymorph Screening Directly from Powder by Peybernès, Guillem, Grossier, Romain, Villard, Frédéric, Letellier, Philippe, Candoni, Nadine, Veesler, Stéphane

“…We describe a microfluidic platform for solid phase screening using extremely small quantities of raw materials. Based on our previous setup for solubility…”
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A new perspective on the interaction between the Vg/VGLL1-3 proteins and the TEAD transcription factors by Mesrouze, Yannick, Aguilar, Gustavo, Bokhovchuk, Fedir, Martin, Typhaine, Delaunay, Clara, Villard, Frédéric, Meyerhofer, Marco, Zimmermann, Catherine, Fontana, Patrizia, Wille, Roman, Vorherr, Thomas, Erdmann, Dirk, Furet, Pascal, Scheufler, Clemens, Schmelzle, Tobias, Affolter, Markus, Chène, Patrick

“…The most downstream elements of the Hippo pathway, the TEAD transcription factors, are regulated by several cofactors, such as Vg/VGLL1-3. Earlier findings on…”
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Microfluidics Setup Rapidly Measures Solubility Directly from Powder by Peybernès, Guillem, Grossier, Romain, Villard, Frédéric, Letellier, Philippe, Lagaize, Mehdi, Candoni, Nadine, Veesler, Stéphane

“…This communication presents a new microfluidics device for solubility measurement based on the generation of saturated solutions starting from powder that is…”
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An unfitted radial basis function generated finite difference method applied to thoracic diaphragm simulations by Tominec, Igor, Villard, Pierre-Frédéric, Larsson, Elisabeth, Bayona, Víctor, Cacciani, Nicola

“…The thoracic diaphragm is the muscle that drives the respiratory cycle of a human being. Using a system of partial differential equations (PDEs) that models…”
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Constellation of Different Retinal Lesions in Tuberous Sclerosis: A Case Report by Villard, Frédéric, DeGottrau, Philippe, Gaillard, Marie-Claire

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Biochemical and Structural Characterization of a Peptidic Inhibitor of the YAP:TEAD Interaction That Binds to the α‑Helix Pocket on TEAD by Mesrouze, Yannick, Gubler, Hanspeter, Villard, Frédéric, Boesch, Ralf, Ottl, Johannes, Kallen, Joerg, Reid, Patrick C., Scheufler, Clemens, Marzinzik, Andreas L., Chène, Patrick

“…The TEAD transcription factors are the most distal elements of the Hippo pathway, and their transcriptional activity is regulated by several proteins,…”
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Retinal Vessel Phenotype in Patients with Nonarteritic Anterior Ischemic Optic Neuropathy by Remond, Perrine, Aptel, Florent, Cunnac, Pierre, Labarere, José, Palombi, Karine, Pepin, Jean-Louis, Pollet-Villard, Frédéric, Hogg, Stephen, Wang, Ruixuan, MacGillivray, Tom, Trucco, Emanuele, Chiquet, Christophe

“…The pathophysiology of nonarteritic anterior ischemic optic neuropathy (NAION) is not completely understood. Studies of the retinal vasculature phenotype in…”
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Study of nycthemeral variations in blood pressure in patients with non-arteritic anterior ischemic optic neuropathy by Gaillard-Groleas, Claire, Ormezzano, Olivier, Pollet-Villard, Frédéric, Vignal, Catherine, Gohier, Philippe, Thuret, Gilles, Rougier, Marie-Bénédicte, Pepin, Jean-Louis, Chiquet, Christophe

“…Purpose The objective of this study was to analyze the nycthemeral variations in blood pressure (BP) in individuals who presented with non-arteritic anterior…”
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