Search Results - "Villar‐Prados, Alejandro"

Hybrid allogeneic bone marrow transplant rescue approach after acute myelogenous leukaemia relapse in a high‐risk patient by Villar‐Prados, Alejandro, Kennedy, Vanessa E., Meyer, Everett H.

Get full text

A single center experience for clinical evaluation of paroxysmal cold hemoglobinuria and Donath‐Landsteiner testing by Villar‐Prados, Alejandro, Abdelmonem, Mohamed, Duda, Molly, Chien, May, Yunce, Muharrem

“…Abstract Background Paroxysmal cold hemoglobinuria (PCH) is a rare form of autoimmune hemolytic anemia (AIHA), mainly affecting children. The diagnosis and…”
Get full text

The highs and lows of cyclic thrombocytopenia by Zhang, Haiyu, Villar-Prados, Alejandro, Bussel, James B, Zehnder, James L

“…Cyclic thrombocytopenia (CTP) is characterized by periodic platelet oscillation with substantial amplitude. Most CTP cases have a thrombocytopenic background…”
Get full text

FABP4 as a key determinant of metastatic potential of ovarian cancer by Gharpure, Kshipra M., Pradeep, Sunila, Sans, Marta, Rupaimoole, Rajesha, Ivan, Cristina, Wu, Sherry Y., Bayraktar, Emine, Nagaraja, Archana S., Mangala, Lingegowda S., Zhang, Xinna, Haemmerle, Monika, Hu, Wei, Rodriguez-Aguayo, Cristian, McGuire, Michael, Mak, Celia Sze Ling, Chen, Xiuhui, Tran, Michelle A., Villar-Prados, Alejandro, Pena, Guillermo Armaiz, Kondetimmanahalli, Ragini, Nini, Ryan, Koppula, Pranavi, Ram, Prahlad, Liu, Jinsong, Lopez-Berestein, Gabriel, Baggerly, Keith, S. Eberlin, Livia, Sood, Anil K.

“…The standard treatment for high-grade serous ovarian cancer is primary debulking surgery followed by chemotherapy. The extent of metastasis and invasive…”
Get full text

Mechanisms of nuclear content loading to exosomes by Yokoi, Akira, Villar-Prados, Alejandro, Oliphint, Paul Allen, Zhang, Jianhua, Song, Xingzhi, De Hoff, Peter, Morey, Robert, Liu, Jinsong, Roszik, Jason, Clise-Dwyer, Karen, Burks, Jared K, O'Halloran, Theresa J, Laurent, Louise C, Sood, Anil K

“…Exosome cargoes are highly varied and include proteins, small RNAs, and genomic DNA (gDNA). The presence of gDNA suggests that different intracellular…”
Get full text

Loss of polarity alters proliferation and differentiation in low-grade endometrial cancers by disrupting Notch signaling by Williams, Erin, Villar-Prados, Alejandro, Bowser, Jessica, Broaddus, Russell, Gladden, Andrew B

“…Cell adhesion and apicobasal polarity together maintain epithelial tissue organization and homeostasis. Loss of adhesion has been described as a prerequisite…”
Get full text

Gain-of-function p53 protein transferred via small extracellular vesicles promotes conversion of fibroblasts to a cancer-associated phenotype by Ma, Shaolin, McGuire, Michael H., Mangala, Lingegowda S., Lee, Sanghoon, Stur, Elaine, Hu, Wen, Bayraktar, Emine, Villar-Prados, Alejandro, Ivan, Cristina, Wu, Sherry Y., Yokoi, Akira, Dasari, Santosh K., Jennings, Nicholas B., Liu, Jinsong, Lopez-Berestein, Gabriel, Ram, Prahlad, Sood, Anil K.

“…Tumor and stromal interactions consist of reciprocal signaling through cytokines, growth factors, direct cell-cell interactions, and extracellular vesicles…”
Get full text

CD63-mediated cloaking of VEGF in small extracellular vesicles contributes to anti-VEGF therapy resistance by Ma, Shaolin, Mangala, Lingegowda S., Hu, Wen, Bayaktar, Emine, Yokoi, Akira, Hu, Wei, Pradeep, Sunila, Lee, Sanghoon, Piehowski, Paul D., Villar-Prados, Alejandro, Wu, Sherry Y., McGuire, Michael H., Lara, Olivia D., Rodriguez-Aguayo, Cristian, LaFargue, Christopher J., Jennings, Nicholas B., Rodland, Karin D., Liu, Tao, Kundra, Vikas, Ram, Prahlad T., Ramakrishnan, Sundaram, Lopez-Berestein, Gabriel, Coleman, Robert L., Sood, Anil K.

“…Despite wide use of anti-vascular endothelial growth factor (VEGF) therapy for many solid cancers, most individuals become resistant to this therapy, leading…”
Get full text

Macrophage depletion through colony stimulating factor 1 receptor pathway blockade overcomes adaptive resistance to anti-VEGF therapy by Lyons, Yasmin A, Pradeep, Sunila, Wu, Sherry Y, Haemmerle, Monika, Hansen, Jean M, Wagner, Michael J, Villar-Prados, Alejandro, Nagaraja, Archana S, Dood, Robert L, Previs, Rebecca A, Hu, Wei, Zhao, Yang, Mak, Duncan H, Xiao, Zhilan, Melendez, Brenda D, Lizee, Gregory A, Mercado-Uribe, Imelda, Baggerly, Keith A, Hwu, Patrick, Liu, Jinsong, Overwijk, Willem W, Coleman, Robert L, Sood, Anil K

“…Anti-angiogenesis therapy has shown clinical benefit in patients with high-grade serous ovarian cancer (HGSC), but adaptive resistance rapidly emerges. Thus,…”
Get full text

Severe Posaconazole-Induced Glucocorticoid Deficiency with Concurrent Pseudohyperaldosteronism: An Unfortunate Two-for-One Special by Villar-Prados, Alejandro, Chang, Julia J., Stevens, David A., Schoolnik, Gary K., Wang, Samantha X. Y.

“…A 56-year-old Hispanic man with a history of disseminated coccidioidomycosis was diagnosed with persistent glucocorticoid insufficiency and…”
Get full text

High Prevalence of Human Papillomavirus in Colorectal Cancer in Hispanics: A Case-Control Study by Rodríguez, Nayra, Yamamura, Yasuhiro, Cruz-Correa, Marcia, Diaz-Algorri, Yaritza, Velazquez, Francisco E., Fonseca-Williams, Sharon, Rodríguez-Arroyo, Heriberto, Lacourt-Ventura, Mercedes, Villar-Prados, Alejandro, Gonzalez-Pons, Maria, Bernabe-Dones, Raul D., Lopez-Diaz, Sofia M.

“…The role of Human Papillomavirus (HPV) in colorectal carcinogenesis remains elusive. Based on the high incidence of HPV-associated malignancies among Puerto…”
Get full text

A Single Center Experience for Clinical Evaluation of Paroxysmal Cold Hemoglobinuria and Donath-Landsteiner Testing by Villar-Prados, Alejandro, Chien, May, Yunce, Muharrem, Abdelmonem, Mohamed, Duda, Molly

“…Introduction: Paroxysmal cold hemoglobinuria (PCH) is a rare form of autoimmune hemolytic anemia (AIHA), mainly affecting children. The diagnosis and…”
Get full text

Immunosuppression in Isocitrate Dehydrogenase Mutated Acute Myeloid Leukemia by Tai, Jesse W., Li, Guan, Tanaka, Kailee, Gopakumar, Jayakrishnan, Zhou, Crystal, Linde, Miles Hamilton, Villar-Prados, Alejandro, Rangavajhula, Athreya S, Trotman-Grant, Aaron C, Landberg, Niklas, Fan, Amy C, Mannis, Gabriel, Zhang, Tian Y.

“…Introduction: Mutations in the isocitrate dehydrogenase (IDHmut) enzymes 1 and 2 are prevalent in a diverse array of human malignancies, including melanoma,…”
Get full text

Abstract LB-232: A novel approach for liquid biopsy by using nExo by Yokoi, Akira, Villar-Prados, Alejandro, Oliphint, Paul Allen, O'Halloran, Theresa J., Roszik, Jason, Sood, Anil K.

“…Abstract Exosomes are small extracellular vesicles secreted from all living cells; its contents are highly varied, including proteins, small RNAs and recently…”
Get full text

Abstract B60: Systematic approach for identifying and validating novel therapies and targets for ovarian cancer by Villar-Prados, Alejandro, Wu, Sherry Y., Roszik, Jason, Engelhardt, Margaret I., Sood, Anil K.

“…Abstract Advances in cancer research have led to the rapid development of novel therapies designed to target specific molecular pathways altered in tumors…”
Get full text

Phase 1 Trial Results for Patients with Advanced Hematologic Malignancies Undergoing Reduced Intensity Allogeneic HCT with Orca-T Donor Cell Therapy Product and Single Agent Tacrolimus by Villar-Prados, Alejandro, Meyer, Everett H., Sutherland, Katherine, Negrin, Robert S., Arai, Sally, Frank, Matthew J., Johnston, Laura, Lowsky, Robert, Miklos, David B., Muffly, Lori S., Dahiya, Saurabh, Rezvani, Andrew R., Sidana, Surbhi, Shiraz, Parveen, Shizuru, Judith, Weng, Wen-Kai, Smith, Melody, Bharadwaj, Sushma, Tamaresis, John, Pavlova, Anna, McClellan, Scott

“…Introduction: Reduced intensity conditioning hematopoietic bone marrow stem cell transplantation (HSCT-RIC) is the only curative option for many hematological…”
Get full text

Characterization and Clinical Outcome of Philadelphia Chromosome-Positive AML in Thrombocytopenia-Absent Radius Syndrome by Villar-Prados, Alejandro, Odabas, Arman, Menke, Joshua R, Kingham, Kerry, Mannis, Gabriel N

Get more information

Abstract 1528: Forecasting novel therapies by understanding the role BRD4 in regulating the Notch3 signaling in ovarian cancer by Villar-Prados, Alejandro, Wu, Sherry Y., Roszik, Jason, Sood, Anil K., Engelhardt, Margaret I.

“…Abstract Advances in cancer research have led to the rapid development of novel drug therapies designed for optimal personalized patient care. Despite this…”
Get full text

GnRH-R-Targeted Lytic Peptide Sensitizes BRCA Wild-type Ovarian Cancer to PARP Inhibition by Ma, Shaolin, Pradeep, Sunila, Villar-Prados, Alejandro, Wen, Yunfei, Bayraktar, Emine, Mangala, Lingegowda S, Kim, Mark Seungwook, Wu, Sherry Y, Hu, Wei, Rodriguez-Aguayo, Cristian, Leuschner, Carola, Liang, Xiaoyan, Ram, Prahlad T, Schlacher, Katharina, Coleman, Robert L, Sood, Anil K

“…EP-100 is a synthetic lytic peptide that specifically targets the gonadotropin-releasing hormone receptor on cancer cells. To extend the utility of EP-100, we…”
Get full text

Induction of anti-VEGF therapy resistance by upregulated expression of microseminoprotein (MSMP) by Mitamura, T, Pradeep, S, McGuire, M, Wu, S Y, Ma, S, Hatakeyama, H, Lyons, Y A, Hisamatsu, T, Noh, K, Villar-Prados, A, Chen, X, Ivan, C, Rodriguez-Aguayo, C, Hu, W, Lopez-Berestein, G, Coleman, R L, Sood, A K

“…Anti-vascular endothelial growth factor (VEGF) therapy has demonstrated efficacy in treating human metastatic cancers, but therapeutic resistance is a…”
Get full text