Search Results - "Villar, José A F P"

Evaluation of neuroprotective activity of digoxin and semisynthetic derivatives against partial chemical ischemia by Souza Gonçalves, Bruno, Moura Valadares, Jéssica M., Alves, Silmara L. G., Silva, Simone C., Rangel, Luciana P., Cortes, Vanessa F., Villar, José A. F. P., Barbosa, Leandro A., Lima Santos, Hérica

“…Recently, cardiotonic steroids (CTS) have been shown to lead to the activation of Na,K‐ATPase at low concentrations in brain, promoting neuroprotection against…”
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Design, synthesis, biological activity and structure-activity relationship studies of chalcone derivatives as potential anti-Candida agents by Andrade, Jéssica T., Santos, Felipe R. S., Lima, William G., Sousa, Carla D. F., Oliveira, Lohanna S. F. M., Ribeiro, Rosy I. M. A., Gomes, Ana J. P. S., Araújo, Marcelo G. F., Villar, José A. F. P., Ferreira, Jaqueline M. S.

“…Vulvovaginal candidiasis (VVC) affects millions of women around the world every year. Candida albicans is the most frequently isolated pathogen in women and…”
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Selectivity analyses of γ-benzylidene digoxin derivatives to different Na,K-ATPase α isoforms: a molecular docking approach by Pessôa, Marco T. C., Alves, Silmara L. G., Taranto, Alex G., Villar, José A. F. P., Blanco, Gustavo, Barbosa, Leandro A.

“…Digoxin and other cardiotonic steroids (CTS) exert their effect by inhibiting Na,K-ATPase (NKA) activity. CTS bind to the various NKA isoforms that are…”
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The Use of Reverse Vaccinology and Molecular Modeling Associated with Cell Proliferation Stimulation Approach to Select Promiscuous Epitopes from Schistosoma mansoni by Oliveira, Flávio M., Coelho, Ivan E. V., Lopes, Marcelo D., Taranto, Alex G., Junior, Moacyr C., Santos, Luciana L. D., Villar, José A. P. F., Fonseca, Cristina T., Lopes, Débora D. O.

“…Schistosomiasis remains an important parasitic disease that affects millions of individuals worldwide. Despite the availability of chemotherapy, the occurrence…”
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Design and synthesis of new chacones substituted with azide/triazole groups and analysis of their cytotoxicity towards HeLa cells by da Silva, Graziele D, da Silva, Marina G, Souza, Estrela M P V E, Barison, Andersson, Simões, Sarah C, Varotti, Fernando P, Barbosa, Leandro A, Viana, Gustavo H R, Villar, José A F P

“…A series of new chalcones substituted with azide/triazole groups were designed and synthesized, and their cytotoxic activity was evaluated in vitro against the…”
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21-Benzylidene digoxin decreases proliferation by inhibiting the EGFR/ERK signaling pathway and induces apoptosis in HeLa cells by Pessôa, Marco Túlio C., Valadares, Jéssica M.M., Rocha, Sayonarah C., Silva, Simone C., McDermott, Jeff P., Sánchez, Gladis, Varotti, Fernando P., Scavone, Cristóforo, Ribeiro, Rosy I.M.A., Villar, José A.F.P., Blanco, Gustavo, Barbosa, Leandro A.

“…[Display omitted] •21-Benzylidene digoxin (21-BD) reduces the proliferation of HeLa cancer cells.•21-BD counteracts an insulin-stimulated proliferation of HeLa…”
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Epitopes rationally selected through computational analyses induce T‐cell proliferation in mice and are recognized by serum from individuals infected with Schistosoma mansoni by Lopes, Marcelo D., Oliveira, Flávio M., Coelho, Ivan E. V., Passos, Maria J. F., Alves, Clarice C., Taranto, Alex G., Júnior, Moacyr C., Santos, Luciana L., Fonseca, Cristina T., Villar, José A. F. P., Lopes, Débora O.

“…Schistosomiasis is the second leading cause of death due to parasitic diseases in the world. Seeking an alternative for the control of disease, the World…”
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Synthesis and in vitro evaluation of novel triazole/azide chalcones by Evangelista, Fernanda C. G., Bandeira, Maralice O., Silva, Graziele D., Silva, Marina G., Andrade, Silmara N., Marques, Deisielly R., Silva, Luciana M., Castro, Whocely V., Santos, Fabio V., Viana, Gustavo H. R., Villar, José A. F. P., Sabino, Adriano P., Varotti, Fernando P.

“…A series of 30 novel triazole/azide chalcone derivatives were synthesized by Claisen-Schmidt and Cu(I)-catalyzed cycloaddition reactions. The antiproliferative…”
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4,4-Dimethyl-2-[3-nitro-2-phenyl-1-(phenyl-sulfan-yl)prop-yl]-4,5-dihydro-1,3-oxazole by Caracelli, Ignez, Zukerman-Schpector, Julio, Villar, José A F P, Oliveira, Alfredo R M, Tiekink, Edward R T

“…In the title compound, C(20)H(22)N(2)O(3)S, the oxazoline ring is planar (r.m.s. deviation = 0.045 Å) and forms dihedral angles of 47.24 (8) and 10.11 (8)°…”
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Involvement of Src signaling in the synergistic effect between cisplatin and digoxin on cancer cell viability by Pereira, Duane G., Salgado, Mariana A.R., Rocha, Sayonarah C., Santos, Hérica L., Villar, José A.F.P., Contreras, Rubén G., Fontes, Carlos F.L., Barbosa, Leandro A., Cortes, Vanessa F.

“…Cisplatin and other platinum‐containing drugs have played a crucial role in anticancer treatments for over 30 years. However, treatment with cisplatin may…”
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γ-Benzylidene digoxin derivatives synthesis and molecular modeling: Evaluation of anticancer and the Na,K-ATPase activity effect by Alves, Silmara L.G., Paixão, Natasha, Ferreira, Letícia G.R., Santos, Felipe R.S., Neves, Luiza D.R., Oliveira, Gisele C., Cortes, Vanessa F., Salomé, Kahlil S., Barison, Andersson, Santos, Fabio V., Cenzi, Gisele, Varotti, Fernando P., Oliveira, Soraya M.F., Taranto, Alex G., Comar, Moacyr, Silva, Luciana M., Noël, François, Quintas, Luis Eduardo M., Barbosa, Leandro A., Villar, José A.F.P.

“…[Display omitted] Cardiotonic steroids (CS), natural compounds with traditional use in cardiology, have been recently suggested to exert potent anticancer…”
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Synthesis and Evaluation of the in vitro Antimicrobial Activity of Triazoles, Morpholines and Thiosemicarbazones by Santos, Felipe R S, Andrade, Jéssica T, Sousa, Carla D F, Fernandes, Joice S, Carmo, Lucas F, Araújo, Marcelo G F, Ferreira, Jaqueline M S, Villar, José A F P

“…Microbial infections is a global public health problem. The aim of this work was to synthesize and evaluate the antimicrobial activity of novel triazoles,…”
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Insect pheromone synthesis in Brazil: an overview by Zarbin, Paulo H. G., Villar, José A. F. P., Corrêa, Arlene G.

“…This review describes the syntheses of insect pheromones developed and published by Brazilian research groups and aims to present the state of the art of this…”
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Differences of lipid membrane modulation and oxidative stress by digoxin and 21-benzylidene digoxin by Silva, Lilian N.D., Pessoa, Marco Tulio C., Alves, Silmara L.G., Venugopal, Jessica, Cortes, Vanessa F., Santos, Herica L., Villar, José A.F.P., Barbosa, Leandro A.

“…Cardiotonic steroids (CTS) are compounds which bind to the Na,K-ATPase, leading to its inhibition and in some cases initiating signaling cascades. Long…”
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Homogeneous CuCl2/TMEDA/TEMPO-Catalyzed chemoselective base- and halogen- free aerobic oxidation of primary alcohols in mild conditions by Silva, Emmanuel D., Alves, Otávio A.L., Ribeiro, RogérioT, Chagas, Rafael C.R., Villar, José A.F.P., Princival, Jefferson L.

“…[Display omitted] •Chemoselective homogeneous catalyst using air as end-oxidant.•Scalable process loading CuCl2/TMEDA in only (0.01 mol %).•Simple aerobic…”
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21-Benzylidene digoxin: a proapoptotic cardenolide of cancer cells that up-regulates Na,K-ATPase and epithelial tight junctions by Rocha, Sayonarah C, Pessoa, Marco T C, Neves, Luiza D R, Alves, Silmara L G, Silva, Luciana M, Santos, Herica L, Oliveira, Soraya M F, Taranto, Alex G, Comar, Moacyr, Gomes, Isabella V, Santos, Fabio V, Paixão, Natasha, Quintas, Luis E M, Noël, François, Pereira, Antonio F, Tessis, Ana C S C, Gomes, Natalia L S, Moreira, Otacilio C, Rincon-Heredia, Ruth, Varotti, Fernando P, Blanco, Gustavo, Villar, Jose A F P, Contreras, Rubén G, Barbosa, Leandro A

“…Cardiotonic steroids are used to treat heart failure and arrhythmia and have promising anticancer effects. The prototypic cardiotonic steroid ouabain may also…”
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Conjugated addition of bis(oxazolinyl)zinc to substituted 2-nitrovinyl benzenes: an alternative synthesis of (±)-Rolipram by Oliveira, Alfredo R.M., Villar, José A.F.P., Simonelli, Fabio, Gariani, Rogério A., Wosch, Celso L., Zarbin, Paulo H.G.

“…Herein we report the conjugated addition of a bis(oxazolinyl)zinc derivative to several 2-nitrovinyl benzenes. This methodology was successfully applied to the…”
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