Search Results - "Villanueva, Silvina S.M."

Effect of acetaminophen on expression and activity of rat liver multidrug resistance-associated protein 2 and P-glycoprotein by Ghanem, Carolina I, Gómez, Paula C, Arana, Marı́a C, Perassolo, Marı́a, Ruiz, Marı́a L, Villanueva, Silvina S.M, Ochoa, Elena J, Catania, Viviana A, Bengochea, Laura A, Mottino, Aldo D

“…We evaluated the effect of acetaminophen (APAP), given as a single, 1 g/kg body weight dose, on expression and activity of rat liver multidrug…”
Get full text

Regulation of expression and activity of multidrug resistance proteins MRP2 and MDR1 by estrogenic compounds in Caco-2 cells. Role in prevention of xenobiotic-induced cytotoxicity by Arias, Agostina, Rigalli, Juan Pablo, Villanueva, Silvina S.M, Ruiz, María L, Luquita, Marcelo G, Perdomo, Virginia G, Vore, Mary, Catania, Viviana A, Mottino, Aldo D

“…Graphical abstract…”
Get full text

Regulation of biotransformation systems and ABC transporters by benznidazole in HepG2 cells: involvement of pregnane X-receptor by Rigalli, Juan P, Perdomo, Virginia G, Luquita, Marcelo G, Villanueva, Silvina S M, Arias, Agostina, Theile, Dirk, Weiss, Johanna, Mottino, Aldo D, Ruiz, María L, Catania, Viviana A

“…Benznidazole (BZL) is the only antichagasic drug available in most endemic countries. Its effect on the expression and activity of drug-metabolizing and…”
Get full text

Beneficial Effect of Spironolactone Administration on Ethynylestradiol-Induced Cholestasis in the Rat: Involvement of Up-Regulation of Multidrug Resistance-Associated Protein 2 by Ruiz, María L, Villanueva, Silvina S M, Luquita, Marcelo G, Ikushiro, Shin-ichi, Mottino, Aldo D, Catania, Viviana A

“…The effect of spironolactone (SL) administration on 17α-ethynylestradiol (EE)-induced cholestasis was studied, with emphasis on expression and activity of…”
Get full text

Co-regulation of expression of phase II metabolizing enzymes and multidrug resistance-associated protein 2 by Catania, Viviana A, Sánchez Pozzi, Enrique J, Luquita, Marcelo G, Ruiz, María L, Villanueva, Silvina S M, Jones, Brett, Mottino, Aldo D

“…Treatment of experimental animals with prototypical enzyme inducers represents a useful tool to characterize the role of different isozymes in drug metabolism…”
Get full text

Ex vivo and in vivo effects of arsenite on GST and ABCC2 activity and expression in the middle intestine of the rainbow trout Oncorhynchus mykiss by Painefilú, Julio C., Pascual, Mariano M., Bieczynski, Flavia, Laspoumaderes, Cecilia, González, Carolina, Villanueva, Silvina S.M., Luquet, Carlos M.

“…In fish of freshwaters environments, the accumulation and toxic effects of arsenite (AsIII) can be attenuated by detoxification proteins such as GST and ABCC…”
Get full text

Physiological and pathophysiological factors affecting the expression and activity of the drug transporter MRP2 in intestine. Impact on its function as membrane barrier by Arana, Maite R., Tocchetti, Guillermo N., Rigalli, Juan P., Mottino, Aldo D., Villanueva, Silvina S.M.

“…[Display omitted] The gastrointestinal epithelium functions as a selective barrier to absorb nutrients, electrolytes and water, but at the same time restricts…”
Get full text

Intraluminal nutrients acutely strengthen rat intestinal MRP2 barrier function by a glucagon‐like peptide‐2‐mediated mechanism by Tocchetti, Guillermo N., Domínguez, Camila J., Zecchinati, Felipe, Arana, Maite R., Rigalli, Juan P., Ruiz, María L., Villanueva, Silvina S. M., Mottino, Aldo D.

“…Aim MRP2 is an intestinal ABC transporter that prevents the absorption of dietary xenobiotics. The aims of this work were: (1) to evaluate whether a short‐term…”
Get full text

Alterations in the intestine of Patagonian silverside (Odontesthes hatcheri) exposed to microcystin-LR: Changes in the glycosylation pattern of the intestinal wall and inhibition of multidrug resistance proteins efflux activity by Bieczynski, Flavia, Torres, Walter D.C., Painefilu, Julio C., Castro, Juan M., Bianchi, Virginia A., Frontera, Jimena L., Paz, Dante A., González, Carolina, Martín, Alejandro, Villanueva, Silvina S.M., Luquet, Carlos M.

“…⿢O. hatcheri received MCLR through the diet for lectin-histochemistry studies.⿢MCLR changed the intestinal epithelium glycoconjugates composition and…”
Get full text

Cellular transport of microcystin-LR in rainbow trout (Oncorhynchus mykiss) across the intestinal wall: Possible involvement of multidrug resistance-associated proteins by Bieczynski, Flavia, De Anna, Julieta S., Pirez, Macarena, Brena, Beatríz M., Villanueva, Silvina S.M., Luquet, Carlos M.

“…•Ex vivo preparations from O. mykiss intestine, for studying microcystin-LR transport.•Microcystin-LR inhibits apical and basolateral transport of Abcc…”
Get full text

Modulation of Biotransformation Systems and ABC Transporters by Benznidazole in Rats by PERDOMO, Virginia G, RIGALLI, Juan P, VILLANUEVA, Silvina S. M, RUIZ, Maria L, LUQUITA, Marcelo G, ECHENIQUE, Claudia G, CATANIA, Viviana A

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Effect of repeated administration with subtoxic doses of acetaminophen to rats on enterohepatic recirculation of a subsequent toxic dose by Ghanem, Carolina I., Ruiz, María L., Villanueva, Silvina S.M., Luquita, Marcelo, Llesuy, Susana, Catania, Viviana A., Bengochea, Laura A., Mottino, Aldo D.

“…Development of resistance to toxic effects of acetaminophen (APAP) was reported in rodents and humans, though the mechanism is only partially understood. We…”
Get full text

Induction of intestinal multidrug resistance-associated protein 2 by glucagon-like Peptide 2 in the rat by Villanueva, Silvina S M, Arias, Agostina, Ruiz, María L, Rigalli, Juan P, Pellegrino, José M, Vore, Mary, Catania, Viviana A, Mottino, Aldo D

“…The effects of glucagon-like peptide 2 (GLP-2) on expression and activity of jejunal multidrug resistance-associated protein 2 (Mrp2; Abcc2) and glutathione…”
Get more information

Effect of glucagon-like peptide 2 on hepatic, renal, and intestinal disposition of 1-chloro-2,4-dinitrobenzene by Villanueva, Silvina S M, Perdomo, Virginia G, Ruiz, María L, Rigalli, Juan P, Arias, Agostina, Luquita, Marcelo G, Vore, Mary, Catania, Viviana A, Mottino, Aldo D

“…The ability of the liver, small intestine, and kidney to synthesize and subsequently eliminate dinitrophenyl-S-glutathione (DNP-SG), a substrate for multidrug…”
Get full text

Induction of intestinal multidrug resistance-associated protein 2 (Mrp2) by spironolactone in rats by Ruiz, María L., Villanueva, Silvina S.M., Luquita, Marcelo G., Pellegrino, José M., Rigalli, Juan P., Arias, Agostina, Sánchez Pozzi, Enrique J., Mottino, Aldo D., Catania, Viviana A.

“…The effect of spironolactone (SL) pretreatment (200 μmol/kg b.w./day, 3 consecutive days) on intestinal multidrug resistance-associated protein 2 (Mrp2) was…”
Get full text

Hepatic Synthesis and Urinary Elimination of Acetaminophen Glucuronide Are Exacerbated in Bile Duct-Ligated Rats by VILLANUEVA, Silvina S. M, RUIZ, Maria L, GHANEM, Carolina I, LUQUITA, Marcelo G, CATANIA, Viviana A, MOTTINO, Aldo D

“…Renal and intestinal disposition of acetaminophen glucuronide (APAP-GLU), a common substrate for multidrug resistance-associated proteins 2 and 3 (Mrp2 and…”
Get full text

Regulation of Expression and Activity of Rat Intestinal Multidrug Resistance-Associated Protein 2 by Cholestatic Estrogens by ARIAS, Agostina, VILLANUEVA, Silvina S. M, RUIZ, Maria L, LUQUITA, Marcelo G, VEGGI, Luis M, PELLEGRINO, José M, VORE, Mary, CATANIA, Viviana A, MOTTINO, Aldo D

“…The effect of the cholestatic estrogens ethynylestradiol (EE) and estradiol 17β- d -glucuronide (E2-17G) on expression and activity of intestinal multidrug…”
Get full text

Shift from biliary to urinary elimination of acetaminophen-glucuronide in acetaminophen-pretreated rats by Ghanem, Carolina I, Ruiz, María L, Villanueva, Silvina S M, Luquita, Marcelo G, Catania, Viviana A, Jones, Brett, Bengochea, Laura A, Vore, Mary, Mottino, Aldo D

“…Despite its toxicity, acetaminophen (APAP) is used increasingly as an analgesic, antipyretic, and anti-inflammatory agent. We examined the effect of prior…”
Get more information

ETHYNYLESTRADIOL INCREASES EXPRESSION AND ACTIVITY OF RAT LIVER MRP3 by RUIZ, Maria L, VILLANUEVA, Silvina S. M, LUQUITA, Marcelo G, VORE, Mary, MOTTINO, Aldo D, CATANIA, Viviana A

“…We evaluated the effect of ethynylestradiol (EE) administration (5 mg/kg b.wt. s.c., for 5 consecutive days) on the expression and activity of multidrug…”
Get full text

HEPATIC AND EXTRAHEPATIC SYNTHESIS AND DISPOSITION OF DINITROPHENYL-S-GLUTATHIONE IN BILE DUCT-LIGATED RATS by VILLANUEVA, Silvina S. M, RUIZ, Maria L, MOTTINO, Aldo D, SOROKA, Carol J, CAI, Shi-Ying, LUQUITA, Marcelo G, TORRES, Adriana M, SANCHEZ POZZI, Enrique J, PELLEGRINO, José M, BOYER, James L, CATANIA, Viviana A

“…The ability of the kidney and small intestine to synthesize and subsequently eliminate dinitrophenyl- S -glutathione (DNP-SG), a substrate for the multidrug…”
Get full text