Search Results - "Villanueva, Erika B."

In Vivo Evaluation of Candidate Allele-specific Mutant Huntingtin Gene Silencing Antisense Oligonucleotides by Southwell, Amber L, Skotte, Niels H, Kordasiewicz, Holly B, Østergaard, Michael E, Watt, Andrew T, Carroll, Jeffrey B, Doty, Crystal N, Villanueva, Erika B, Petoukhov, Eugenia, Vaid, Kuljeet, Xie, Yuanyun, Freier, Susan M, Swayze, Eric E, Seth, Punit P, Bennett, Clarence Frank, Hayden, Michael R

“…Huntington disease (HD) is a dominant, genetic neurodegenerative disease characterized by progressive loss of voluntary motor control, psychiatric disturbance,…”
Get full text

Anti-semaphorin 4D immunotherapy ameliorates neuropathology and some cognitive impairment in the YAC128 mouse model of Huntington disease by Southwell, Amber L, Franciosi, Sonia, Villanueva, Erika B, Xie, Yuanyun, Winter, Laurie A, Veeraraghavan, Janaki, Jonason, Alan, Felczak, Boguslaw, Zhang, Weining, Kovalik, Vlad, Waltl, Sabine, Hall, George, Pouladi, Mahmoud A, Smith, Ernest S, Bowers, William J, Zauderer, Maurice, Hayden, Michael R

“…Abstract Huntington disease (HD) is an inherited, fatal neurodegenerative disease with no disease-modifying therapy currently available. In addition to…”
Get full text

Rational design of antisense oligonucleotides targeting single nucleotide polymorphisms for potent and allele selective suppression of mutant Huntingtin in the CNS by Østergaard, Michael E., Southwell, Amber L., Kordasiewicz, Holly, Watt, Andrew T., Skotte, Niels H., Doty, Crystal N., Vaid, Kuljeet, Villanueva, Erika B., Swayze, Eric E., Frank Bennett, C., Hayden, Michael R., Seth, Punit P.

Get full text

Moderate increase in temperature may exacerbate neuroinflammatory processes in the brain: Human cell culture studies by Bahniwal, Manpreet, Villanueva, Erika B, Klegeris, Andis

“…Abstract The effect of a moderate, physiologically relevant rise in temperature on several neuroinflammatory parameters was investigated in vitro using human…”
Get full text

Secreted phospholipase A2 group IIA is a neurotoxin released by stimulated human glial cells by Villanueva, Erika B., Little, Jonathan P., Lambeau, Gérard, Klegeris, Andis

“…Neuroinflammation, which is one of the hallmarks of neurodegenerative disorders such as Alzheimer's disease, involves secretion of pro-inflammatory mediators…”
Get full text

An enhanced Q175 knock-in mouse model of Huntington disease with higher mutant huntingtin levels and accelerated disease phenotypes by Southwell, Amber L, Smith-Dijak, Amy, Kay, Chris, Sepers, Marja, Villanueva, Erika B, Parsons, Matthew P, Xie, Yuanyun, Anderson, Lisa, Felczak, Boguslaw, Waltl, Sabine, Ko, Seunghyun, Cheung, Daphne, Dal Cengio, Louisa, Slama, Ramy, Petoukhov, Eugenia, Raymond, Lynn A, Hayden, Michael R

“…Huntington disease (HD) model mice with heterozygous knock-in (KI) of an expanded CAG tract in exon 1 of the mouse huntingtin (Htt) gene homolog genetically…”
Get full text

Rational design of antisense oligonucleotides targeting single nucleotide polymorphisms for potent and allele selective suppression of mutant Huntingtin in the CNS by Østergaard, Michael E, Southwell, Amber L, Kordasiewicz, Holly, Watt, Andrew T, Skotte, Niels H, Doty, Crystal N, Vaid, Kuljeet, Villanueva, Erika B, Swayze, Eric E, Bennett, C Frank, Hayden, Michael R, Seth, Punit P

“…Autosomal dominant diseases such as Huntington's disease (HD) are caused by a gain of function mutant protein and/or RNA. An ideal treatment for these diseases…”
Get full text

Ultrasensitive measurement of huntingtin protein in cerebrospinal fluid demonstrates increase with Huntington disease stage and decrease following brain huntingtin suppression by Southwell, Amber L., Smith, Stephen E.P., Davis, Tessa R., Caron, Nicholas S., Villanueva, Erika B., Xie, Yuanyun, Collins, Jennifer A., Li Ye, Min, Sturrock, Aaron, Leavitt, Blair R., Schrum, Adam G., Hayden, Michael R.

“…Quantitation of huntingtin protein in the brain is needed, both as a marker of Huntington disease (HD) progression and for use in clinical gene silencing…”
Get full text

Mitochondrial transcription factor A (Tfam) is a pro-inflammatory extracellular signaling molecule recognized by brain microglia by Little, Jonathan P., Simtchouk, Svetlana, Schindler, Stephanie M., Villanueva, Erika B., Gill, Nichole E., Walker, Douglas G., Wolthers, Kirsten R., Klegeris, Andis

“…Microglia represent mononuclear phagocytes in the brain and perform immune surveillance, recognizing a number of signaling molecules released from surrounding…”
Get full text

Neuronal TNFα, Not α‐Syn, Underlies PDD‐Like Disease Progression in IFNβ‐KO Mice by Villanueva, Erika B., Tresse, Emilie, Liu, Yawei, Duarte, João N., Jimenez‐Duran, Gisela, Ejlerskov, Patrick, Kretz, Oliver, Loreth, Desiree, Goldmann, Tobias, Prinz, Marco, Issazadeh‐Navikas, Shohreh

“…Objective Parkinson's disease (PD) manifests in motor dysfunction, non‐motor symptoms, and eventual dementia (PDD). Neuropathological hallmarks include…”
Get full text

HACE1 is essential for astrocyte mitochondrial function and influences Huntington disease phenotypes in vivo by Ehrnhoefer, Dagmar E, Southwell, Amber L, Sivasubramanian, Meenalochani, Qiu, Xiaofan, Villanueva, Erika B, Xie, Yuanyun, Waltl, Sabine, Anderson, Lisa, Fazeli, Anita, Casal, Lorenzo, Felczak, Boguslaw, Tsang, Michelle, Hayden, Michael R

“…Abstract Oxidative stress is a prominent feature of Huntington disease (HD), and we have shown previously that reduced levels of hace1 (HECT domain and Ankyrin…”
Get full text

A fully humanized transgenic mouse model of Huntington disease by Southwell, Amber L, Warby, Simon C, Carroll, Jeffrey B, Doty, Crystal N, Skotte, Niels H, Zhang, Weining, Villanueva, Erika B, Kovalik, Vlad, Xie, Yuanyun, Pouladi, Mahmoud A, Collins, Jennifer A, Yang, X William, Franciosi, Sonia, Hayden, Michael R

“…Silencing the mutant huntingtin gene (muHTT) is a direct and simple therapeutic strategy for the treatment of Huntington disease (HD) in principle. However,…”
Get full text

Synthesis and biological evaluation of novel pyrazolyl-2,4-thiazolidinediones as anti-inflammatory and neuroprotective agents by Youssef, Amal M., Sydney White, M., Villanueva, Erika B., El-Ashmawy, Ibrahim M., Klegeris, Andis

“…A number of in vitro and in vivo assays were used to identify four novel pyrazolyl-2,4-thiazolidinediones ( 5a– c, 7b) as potential anti-inflammatory and…”
Get full text

Secreted phospholipase A(2) group IIA is a neurotoxin released by stimulated human glial cells by Villanueva, Erika B, Little, Jonathan P, Lambeau, Gérard, Klegeris, Andis

“…Neuroinflammation, which is one of the hallmarks of neurodegenerative disorders such as Alzheimer's disease, involves secretion of pro-inflammatory mediators…”
Get full text

A novel humanized mouse model of Huntington disease for preclinical development of therapeutics targeting mutant huntingtin alleles by Southwell, Amber L, Skotte, Niels H, Villanueva, Erika B, Østergaard, Michael E, Gu, Xiaofeng, Kordasiewicz, Holly B, Kay, Chris, Cheung, Daphne, Xie, Yuanyun, Waltl, Sabine, Dal Cengio, Louisa, Findlay-Black, Hailey, Doty, Crystal N, Petoukhov, Eugenia, Iworima, Diepiriye, Slama, Ramy, Ooi, Jolene, Pouladi, Mahmoud A, Yang, X William, Swayze, Eric E, Seth, Punit P, Hayden, Michael R

“…Huntington disease (HD) is a neurodegenerative disease caused by a mutation in the huntingtin (HTT) gene. HTT is a large protein, interacts with many partners…”
Get full text

Synthesis and biological evaluation of novel pyrazole compounds by Youssef, Amal M., Neeland, Edward G., Villanueva, Erika B., White, M. Sydney, El-Ashmawy, Ibrahim M., Patrick, Brian, Klegeris, Andis, Abd-El-Aziz, Alaa S.

“…A novel dipyrazole ethandiamide lead compound 3 has been synthesized and reacted with a number of nucleophiles. Two compounds (3 and 4d) were identified as…”
Get full text

Cultured adult porcine astrocytes and microglia express functional interferon-γ receptors and exhibit toxicity towards SH-SY5Y cells by Ionescu, Vlad A, Villanueva, Erika B, Hashioka, Sadayuki, Bahniwal, Manpreet, Klegeris, Andis

“…Abstract In vitro cultures of various glial cell types are common systems used to model neuroinflammatory processes associated with age-dependent human…”
Get full text

I09 Antibodies inhibit cell to cell transmission of mutant HTT by Bartl, Stefan, Oueslati, Abid, Southwell, Amber L, Parth, Michela, Salhat, Nina, Siddu, Alberto, Burkert, Markus, Pankevych, Halyna, David, Linda, Villanueva, Erika B, Xie, Yuanyun, Louisa Dal Cengio, Ko, Seungyun, Hayden, Michael R, Cicchetti, Francesca, Smrzka, Oskar W

“…The toxic functions of the mutant Huntingtin protein (mutHTT) were studied extensively and in addition to neuronal based symptoms, also peripheral changes upon…”
Get full text

696. Pre-Clinical Evaluation of Allele-Specific Mutant Huntingtin Gene Silencing Antisense Oligonucleotides by Southwell, Amber L., Skotte, Niels H., Caron, Nicholas, Kordasiewicz, Holly, Oestergaard, Michael, Doty, Crystal N., Villanueva, Erika B., Xie, Yuanyun, Felczak, Boguslaw, Freier, Susan M., Swayze, Eric E., Seth, Punit P., Frank Bennet, C., Hayden, Michael R.

Get full text