Search Results - "Villanueva, Augusto"

Hepatocellular Carcinoma by Villanueva, Augusto

“…Primary liver cancer is the fourth most common tumor worldwide. Hepatocellular carcinoma occurs mainly in the context of cirrhosis, hepatitis B or C virus…”
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Tumour evolution in hepatocellular carcinoma by Craig, Amanda J., von Felden, Johann, Garcia-Lezana, Teresa, Sarcognato, Samantha, Villanueva, Augusto

“…Hepatocellular carcinoma (HCC), the most common form of primary liver cancer, typically develops on the background of chronic liver disease and is an…”
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Liver Cancer Cell of Origin, Molecular Class, and Effects on Patient Prognosis by Sia, Daniela, Villanueva, Augusto, Friedman, Scott L, Llovet, Josep M

“…Primary liver cancer is the second leading cause of cancer-related death worldwide and therefore a major public health challenge. We review hypotheses of the…”
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Randomized trials and endpoints in advanced HCC: Role of PFS as a surrogate of survival by Llovet, Josep M., Montal, Robert, Villanueva, Augusto

“…Hepatocellular carcinoma (HCC) is a major cause of cancer-related mortality worldwide. Around half of patients with HCC will receive systemic therapies during…”
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Genetic Landscape and Biomarkers of Hepatocellular Carcinoma by Zucman-Rossi, Jessica, Villanueva, Augusto, Nault, Jean-Charles, Llovet, Josep M

“…Hepatocellular carcinoma (HCC) has emerged as a major cause of cancer-related death. Its mortality has increased in Western populations, with a minority of…”
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Genetic profiling of hepatocellular carcinoma using next-generation sequencing by Schulze, Kornelius, Nault, Jean-Charles, Villanueva, Augusto

“…Summary Hepatocellular carcinoma (HCC) is a highly heterogeneous disease, both clinically and from a molecular standpoint. The advent of next-generation…”
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Rethinking future development of molecular therapies in hepatocellular carcinoma: A bottom-up approach by Villanueva, Augusto

“…Summary The high failure rate of phase 3 trials in oncology is forcing the scientific community to rethink drug development strategies and optimize trial…”
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Advances in targeted therapies for hepatocellular carcinoma in the genomic era by Llovet, Josep M., Villanueva, Augusto, Lachenmayer, Anja, Finn, Richard S.

“…Key Points The global incidence of liver cancer is increasing, with reports indicating that disease-specific mortality has doubled in the past 20 years…”
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Intratumoral heterogeneity and clonal evolution in liver cancer by Losic, Bojan, Craig, Amanda J., Villacorta-Martin, Carlos, Martins-Filho, Sebastiao N., Akers, Nicholas, Chen, Xintong, Ahsen, Mehmet E., von Felden, Johann, Labgaa, Ismail, DʹAvola, Delia, Allette, Kimaada, Lira, Sergio A., Furtado, Glaucia C., Garcia-Lezana, Teresa, Restrepo, Paula, Stueck, Ashley, Ward, Stephen C., Fiel, Maria I., Hiotis, Spiros P., Gunasekaran, Ganesh, Sia, Daniela, Schadt, Eric E., Sebra, Robert, Schwartz, Myron, Llovet, Josep M., Thung, Swan, Stolovitzky, Gustavo, Villanueva, Augusto

“…Clonal evolution of a tumor ecosystem depends on different selection pressures that are principally immune and treatment mediated. We integrate RNA-seq, DNA…”
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Hepatocellular carcinoma by Llovet, Josep M., Kelley, Robin Kate, Villanueva, Augusto, Singal, Amit G., Pikarsky, Eli, Roayaie, Sasan, Lencioni, Riccardo, Koike, Kazuhiko, Zucman-Rossi, Jessica, Finn, Richard S.

“…Liver cancer remains a global health challenge, with an estimated incidence of >1 million cases by 2025. Hepatocellular carcinoma (HCC) is the most common form…”
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Mutations in circulating tumor DNA predict primary resistance to systemic therapies in advanced hepatocellular carcinoma by von Felden, Johann, Craig, Amanda J., Garcia-Lezana, Teresa, Labgaa, Ismail, Haber, Philipp K., D’Avola, Delia, Asgharpour, Amon, Dieterich, Douglas, Bonaccorso, Antoinette, Torres-Martin, Miguel, Sia, Daniela, Sung, Max W., Tabrizian, Parissa, Schwartz, Myron, Llovet, Josep M., Villanueva, Augusto

“…Little is known about the mutational landscape of advanced hepatocellular carcinoma (HCC), and predictive biomarkers of response to systemic therapies are…”
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Evidence-Based Management of Hepatocellular Carcinoma: Systematic Review and Meta-analysis of Randomized Controlled Trials (2002–2020) by Haber, Philipp K., Puigvehí, Marc, Castet, Florian, Lourdusamy, Vennis, Montal, Robert, Tabrizian, Parissa, Buckstein, Michael, Kim, Edward, Villanueva, Augusto, Schwartz, Myron, Llovet, Josep M.

“…Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality, with a rapidly changing landscape of treatments. In the past 20 years, numerous…”
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Medical therapies for hepatocellular carcinoma: a critical view of the evidence by Villanueva, Augusto, Hernandez-Gea, Virginia, Llovet, Josep M.

“…As the burden of hepatocellular carcinoma (HCC) continues to increase, attention turns to the appropriate management of the disease. In this Review, the…”
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Emerging Tools for Hepatocellular Carcinoma Surveillance by Singal, Amit G., Reig, Maria, Villanueva, Augusto

“…Abdominal ultrasound, with or without alpha-fetoprotein, is the recommended strategy for hepatocellular carcinoma (HCC) surveillance but misses over one-third…”
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Intratumor molecular and phenotypic diversity in hepatocellular carcinoma by Nault, Jean-Charles, Villanueva, Augusto

“…Hepatocellular carcinoma is a highly heterogeneous disease both at the molecular and clinical levels. Intratumor morphologic and genetic heterogeneity adds a…”
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Trial Design and Endpoints in Hepatocellular Carcinoma: AASLD Consensus Conference by Llovet, Josep M., Villanueva, Augusto, Marrero, Jorge A., Schwartz, Myron, Meyer, Tim, Galle, Peter R., Lencioni, Riccardo, Greten, Tim F., Kudo, Masatoshi, Mandrekar, Sumithra J., Zhu, Andrew X., Finn, Richard S., Roberts, Lewis R.

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Identification of an Immune-specific Class of Hepatocellular Carcinoma, Based on Molecular Features by Sia, Daniela, Jiao, Yang, Martinez-Quetglas, Iris, Kuchuk, Olga, Villacorta-Martin, Carlos, Castro de Moura, Manuel, Putra, Juan, Camprecios, Genis, Bassaganyas, Laia, Akers, Nicholas, Losic, Bojan, Waxman, Samuel, Thung, Swan N, Mazzaferro, Vincenzo, Esteller, Manel, Friedman, Scott L, Schwartz, Myron, Villanueva, Augusto, Llovet, Josep M

“…Abstract Background and Aims Agents that induce an immune response against tumors by altering T-cell regulation have increased survival times of patients with…”
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Exome sequencing of hepatocellular carcinomas identifies new mutational signatures and potential therapeutic targets by Schulze, Kornelius, Imbeaud, Sandrine, Letouzé, Eric, Alexandrov, Ludmil B, Calderaro, Julien, Rebouissou, Sandra, Couchy, Gabrielle, Meiller, Clément, Shinde, Jayendra, Soysouvanh, Frederic, Calatayud, Anna-Line, Pinyol, Roser, Pelletier, Laura, Balabaud, Charles, Laurent, Alexis, Blanc, Jean-Frederic, Mazzaferro, Vincenzo, Calvo, Fabien, Villanueva, Augusto, Nault, Jean-Charles, Bioulac-Sage, Paulette, Stratton, Michael R, Llovet, Josep M, Zucman-Rossi, Jessica

“…Jessica Zucman-Rossi and colleagues report exome sequences of 243 hepatocellular carcinomas. They identify mutational signatures associated with specific risk…”
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Molecular pathogenesis and systemic therapies for hepatocellular carcinoma by Llovet, Josep M, Pinyol, Roser, Kelley, Robin K, El-Khoueiry, Anthony, Reeves, Helen L, Wang, Xin Wei, Gores, Gregory J, Villanueva, Augusto

“…Hepatocellular carcinoma (HCC) remains one of the most prevalent and deadliest cancers. The poor outcome associated with HCC is dramatically changing due to…”
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VEGF signaling in cancer treatment by Sia, Daniela, Alsinet, Clara, Newell, Pippa, Villanueva, Augusto

“…Induction of angiogenesis represents one of the major hallmarks of cancer. The growth of new vessels is crucial to provide malignant cells with an adequate…”
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