Search Results - "Villani, Laura"

EZH2 mutational status predicts poor survival in myelofibrosis by Guglielmelli, Paola, Biamonte, Flavia, Score, Joannah, Hidalgo-Curtis, Claire, Cervantes, Francisco, Maffioli, Margherita, Fanelli, Tiziana, Ernst, Thomas, Winkelman, Nils, Jones, Amy V., Zoi, Katerina, Reiter, Andreas, Duncombe, Andrew, Villani, Laura, Bosi, Alberto, Barosi, Giovanni, Cross, Nicholas C.P., Vannucchi, Alessandro M.

“…We genotyped 370 subjects with primary myelofibrosis (PMF) and 148 with postpolycythemia vera/postessential thrombocythemia (PPV/PET) MF for mutations of EZH2…”
Get full text

Human Astrocyte Spheroids as Suitable In Vitro Screening Model to Evaluate Synthetic Cannabinoid MAM2201-Induced Effects on CNS by De Simone, Uliana, Pignatti, Patrizia, Villani, Laura, Russo, Luciana Alessandra, Sargenti, Azzurra, Bonetti, Simone, Buscaglia, Eleonora, Coccini, Teresa

“…There is growing concern about the consumption of synthetic cannabinoids (SCs), one of the largest groups of new psychoactive substances, its consequence on…”
Get full text

Ultrastructural analysis of breast cancer patient-derived organoids by Signati, Lorena, Allevi, Raffaele, Piccotti, Francesca, Albasini, Sara, Villani, Laura, Sevieri, Marta, Bonizzi, Arianna, Corsi, Fabio, Mazzucchelli, Serena

“…Abstract Background Breast cancer Patient Derived Organoids (PDO) have been demonstrated to be a reliable model to study cancer that promised to replace and…”
Get full text

Elements Related to Heterogeneity of Antibody-Dependent Cell Cytotoxicity in Patients Under Trastuzumab Therapy for Primary Operable Breast Cancer Overexpressing Her2 by VARCHETTA, Stefania, GIBELLI, Nadia, COSTA, Alberto, FAGNONI, Francesco F, OLIVIERO, Barbara, NARDINI, Elena, GENNARI, Roberto, GATTI, Giovanna, SANTOS SILVA, Luzemira, VILLANI, Laura, TAGLIABUE, Elda, MENARD, Sylvie

“…Preliminary results from a pilot trial on trastuzumab's mechanism of action against operable breast tumors overexpressing Her2 suggested a role for…”
Get full text

Evidence that prefibrotic myelofibrosis is aligned along a clinical and biological continuum featuring primary myelofibrosis by Barosi, Giovanni, Rosti, Vittorio, Bonetti, Elisa, Campanelli, Rita, Carolei, Adriana, Catarsi, Paolo, Isgrò, Antonina M, Lupo, Letizia, Massa, Margherita, Poletto, Valentina, Viarengo, Gianluca, Villani, Laura, Magrini, Umberto

“…In the WHO diagnostic classification, prefibrotic myelofibrosis (pre-MF) is included in the category of primary myelofibrosis (PMF). However, strong evidence…”
Get full text

JAK2 V617F mutational status predicts progression to large splenomegaly and leukemic transformation in primary myelofibrosis by Barosi, Giovanni, Bergamaschi, Gaetano, Marchetti, Monia, Vannucchi, Alessandro M., Guglielmelli, Paola, Antonioli, Elisabetta, Massa, Margherita, Rosti, Vittorio, Campanelli, Rita, Villani, Laura, Viarengo, Gianluca, Gattoni, Elisabetta, Gerli, Giancarla, Specchia, Giorgina, Tinelli, Carmine, Rambaldi, Alessandro, Barbui, Tiziano

“…Few investigators have evaluated the usefulness of the JAK2 V617F mutation for explaining the phenotypic variations and for predicting the risk of major…”
Get full text

3D human stem-cell-derived neuronal spheroids for in vitro neurotoxicity testing of methylglyoxal, highly reactive glycolysis byproduct and potent glycating agent by Coccini, Teresa, Caloni, Francesca, Russo, Luciana Alessandra, Villani, Laura, Lonati, Davide, De Simone, Uliana

“…[Display omitted] •In vitro 3D human stem-cell-derived neurospheroids served as useful tool for toxicity testing of dicarbonyls.•Low MGO levels altered…”
Get full text

Constitutive STAT5 phosphorylation in CD34+ cells of patients with primary myelofibrosis: Correlation with driver mutation status and disease severity by Abbà, Carlotta, Campanelli, Rita, Catarsi, Paolo, Villani, Laura, Abbonante, Vittorio, Sesta, Melania Antonietta, Barosi, Giovanni, Rosti, Vittorio, Massa, Margherita

“…Primary Myelofibrosis (PMF) is a myeloproliferative disorder associated with JAK2V617F, Calreticulin (CALR) indels, and MPLW515L/K mutations activating the…”
Get full text

Characteristics and clinical correlates of MPL 515W>L/K mutation in essential thrombocythemia by Vannucchi, Alessandro M., Antonioli, Elisabetta, Guglielmelli, Paola, Pancrazzi, Alessandro, Guerini, Vittoria, Barosi, Giovanni, Ruggeri, Marco, Specchia, Giorgina, Lo-Coco, Francesco, Delaini, Federica, Villani, Laura, Finotto, Silvia, Ammatuna, Emanuele, Alterini, Renato, Carrai, Valentina, Capaccioli, Gloria, Lollo, Simonetta Di, Liso, Vincenzo, Rambaldi, Alessandro, Bosi, Alberto, Barbui, Tiziano

“…Among 994 patients with essential thrombocythemia (ET) who were genotyped for the MPLW515L/K mutation, 30 patients carrying the mutation were identified…”
Get full text

Pilot Study of the Mechanism of Action of Preoperative Trastuzumab in Patients with Primary Operable Breast Tumors Overexpressing HER2 by GENNARI, Roberto, MENARD, Sylvie, OLIVIERO, Barbara, BALLARDINI, Bettina, DA PRADA, Gianantonio, ZAMBELLI, Alberto, COSTA, Alberto, FAGNONI, Francesco, PONCHIO, Luisa, SCELSI, Mario, TAGLIABUE, Elda, CASTIGLIONI, Fabio, VILLANI, Laura, MAGALOTTI, Cesare, GIBELLI, Nadia

“…Purpose: To elucidate the mechanism by which trastuzumab, a humanized monoclonal antibody against HER2 with proven survival benefit in women with HER2-positive…”
Get full text

Breast cancer patient-derived organoids for the investigation of patient-specific tumour evolution by Mazzucchelli, Serena, Signati, Lorena, Messa, Letizia, Franceschini, Alma, Bonizzi, Arianna, Castagnoli, Lorenzo, Gasparini, Patrizia, Consolandi, Clarissa, Mangano, Eleonora, Pelucchi, Paride, Cifola, Ingrid, Camboni, Tania, Severgnini, Marco, Villani, Laura, Tagliaferri, Barbara, Carelli, Stephana, Pupa, Serenella M, Cereda, Cristina, Corsi, Fabio

“…A reliable preclinical model of patient-derived organoids (PDOs) was developed in a case study of a 69-year-old woman diagnosed with breast cancer (BC) to…”
Get full text

Bidirectional Ventricular Tachycardia and Fibrillation Elicited in a Knock-In Mouse Model Carrier of a Mutation in the Cardiac Ryanodine Receptor by Cerrone, Marina, Colombi, Barbara, Santoro, Massimo, di Barletta, Marina Raffaele, Scelsi, Mario, Villani, Laura, Napolitano, Carlo, Priori, Silvia G

“…Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an inherited disease characterized by adrenergically mediated polymorphic ventricular…”
Get full text

The Relationships between HER2 Overexpression and DCIS Characteristics by Di Cesare, Pamela, Pavesi, Lorenzo, Villani, Laura, Battaglia, Andrea, Da Prada, Gian Antonio, Riccardi, Alberto, Frascaroli, Mara

“…The aim of this study was to demonstrate the correlation between human epidermal growth factor receptor 2 (HER2) overexpression and some poor prognosis factors…”
Get more information

Platelet Rich Plasma Enhancement of Skin Regeneration in an ex-vivo Human Experimental Model by Nicoletti, Giovanni, Saler, Marco, Villani, Laura, Rumolo, Agnese, Tresoldi, Marco Mario, Faga, Angela

“…This study reports on the development of an original, wounded skin culture protocol using autologous Platelet Rich Plasma (PRP) and enriched Dulbecco's…”
Get full text

Small bowel villous atrophy due to immune-checkpoint inhibitors: report of two cases and literature review by Annalisa Schiepatti, Andrea Premoli, Stiliano Maimaris, Mimma Rizzo, Maria Marples, Laura Villani, Nigel Scott, Federico Sottotetti, David S Sanders, Federico Biagi, Clare Donnellan

“…The differential diagnosis of non-coeliac enteropathies (NCEs) is challenging and includes a wide range of aetiologies. Drug-induced NCEs are relatively common…”
Get full text

Whitlockite has a characteristic distribution in mammary microcalcifications and it is not associated with breast cancer by Morasso, Carlo, Vanna, Renzo, Piccotti, Francesca, Frizzi, Lidia, Truffi, Marta, Albasini, Sara, Borca, Camelia, Huthwelker, Thomas, Villani, Laura, Bunk, Oliver, Giannini, Cinzia, Corsi, Fabio

“…List of abbreviations MCs microcalcifications HAp hydroxyapatite Whit whitlockite Mg magnesium DCIS ductal carcinoma in-situ IDC invasive ductal carcinoma XRF…”
Get full text

JAK2 exon 14 skipping in patients with primary myelofibrosis: a minor splice variant modulated by the JAK2-V617F allele burden by Catarsi, Paolo, Rosti, Vittorio, Morreale, Giacomo, Poletto, Valentina, Villani, Laura, Bertorelli, Roberto, Pedrazzini, Matteo, Zorzetto, Michele, Barosi, Giovanni

“…Primary myelofibrosis (PMF) is an acquired clonal disease of the hematopoietic stem cell compartment, characterized by bone marrow fibrosis, anemia,…”
Get full text

Role of androgen receptor expression in early stage ER+/PgR−/HER2– breast cancer by Tagliaferri, Barbara, Quaquarini, Erica, Palumbo, Raffaella, Balletti, Emanuela, Presti, Daniele, Malovini, Alberto, Agozzino, Manuela, Teragni, Cristina Maria, Terzoni, Andrea, Bernardo, Antonio, Villani, Laura, Sottotetti, Federico

“…Background: Progesterone receptor (PgR) negative breast cancer (BC) is an aggressive subtype with poor prognosis and reduced response to endocrine treatments…”
Get full text

JAK2 V617F genotype is a strong determinant of blast transformation in primary myelofibrosis by Barosi, Giovanni, Poletto, Valentina, Massa, Margherita, Campanelli, Rita, Villani, Laura, Bonetti, Elisa, Viarengo, Gianluca, Catarsi, Paolo, Klersy, Catherine, Rosti, Vittorio

“…The influence of JAK2 V617F mutation on blast transformation (BT) and overall survival (OS) in primary myelofibrosis (PMF) is controversial. In a large cohort…”
Get full text

Serum hepcidin: a novel diagnostic tool in disorders of iron metabolism by BERGAMASCHI, Gaetano, VILLANI, Laura

“…During the last few years new methods for the measurement of hepcidin concentration have been developed. In this perspective article, Drs. Bergamaschi and…”
Get full text