Search Results - "Villamor, N"

Clinical impact of the subclonal architecture and mutational complexity in chronic lymphocytic leukemia by Nadeu, F, Clot, G, Delgado, J, Martín-García, D, Baumann, T, Salaverria, I, Beà, S, Pinyol, M, Jares, P, Navarro, A, Suárez-Cisneros, H, Aymerich, M, Rozman, M, Villamor, N, Colomer, D, González, M, Alcoceba, M, Terol, M J, Navarro, B, Colado, E, Payer, ÁR, Puente, X S, López-Otín, C, López-Guillermo, A, Enjuanes, A, Campo, E

“…Genome studies of chronic lymphocytic leukemia (CLL) have revealed the remarkable subclonal heterogeneity of the tumors, but the clinical implications of this…”
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Recurrent mutations refine prognosis in chronic lymphocytic leukemia by Baliakas, P, Hadzidimitriou, A, Sutton, L-A, Rossi, D, Minga, E, Villamor, N, Larrayoz, M, Kminkova, J, Agathangelidis, A, Davis, Z, Tausch, E, Stalika, E, Kantorova, B, Mansouri, L, Scarfò, L, Cortese, D, Navrkalova, V, Rose-Zerilli, M J J, Smedby, K E, Juliusson, G, Anagnostopoulos, A, Makris, A M, Navarro, A, Delgado, J, Oscier, D, Belessi, C, Stilgenbauer, S, Ghia, P, Pospisilova, S, Gaidano, G, Campo, E, Strefford, J C, Stamatopoulos, K, Rosenquist, R

“…Through the European Research Initiative on chronic lymphocytic leukemia (CLL) (ERIC), we screened 3490 patients with CLL for mutations within the NOTCH1 ( n…”
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Survival analysis in hematologic malignancies: recommendations for clinicians by Delgado, Julio, Pereira, Arturo, Villamor, Neus, López-Guillermo, Armando, Rozman, Ciril

“…The widespread availability of statistical packages has undoubtedly helped hematologists worldwide in the analysis of their data, but has also led to the…”
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Improving efficiency and sensitivity: European Research Initiative in CLL (ERIC) update on the international harmonised approach for flow cytometric residual disease monitoring in CLL by Rawstron, A C, Böttcher, S, Letestu, R, Villamor, N, Fazi, C, Kartsios, H, de Tute, R M, Shingles, J, Ritgen, M, Moreno, C, Lin, K, Pettitt, A R, Kneba, M, Montserrat, E, Cymbalista, F, Hallek, M, Hillmen, P, Ghia, P

“…Detection of minimal residual disease (MRD) in chronic lymphocytic leukaemia (CLL) is becoming increasingly important as treatments improve. An internationally…”
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Harms and benefits of lymphocyte subpopulations in patients with acute stroke by Urra, X, Cervera, Á, Villamor, N, Planas, A.M, Chamorro, Á

“…Abstract Lymphocytes are major players in the development of innate and adaptive immune responses but their behavior in patients with acute stroke has received…”
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A B-cell epigenetic signature defines three biologic subgroups of chronic lymphocytic leukemia with clinical impact by Queirós, A C, Villamor, N, Clot, G, Martinez-Trillos, A, Kulis, M, Navarro, A, Penas, E M M, Jayne, S, Majid, A, Richter, J, Bergmann, A K, Kolarova, J, Royo, C, Russiñol, N, Castellano, G, Pinyol, M, Bea, S, Salaverria, I, López-Guerra, M, Colomer, D, Aymerich, M, Rozman, M, Delgado, J, Giné, E, González-Díaz, M, Puente, X S, Siebert, R, Dyer, M J S, López-Otín, C, Rozman, C, Campo, E, López-Guillermo, A, Martín-Subero, J I

“…Prospective identification of patients with chronic lymphocytic leukemia (CLL) destined to progress would greatly facilitate their clinical management…”
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NOTCH1 mutations identify a genetic subgroup of chronic lymphocytic leukemia patients with high risk of transformation and poor outcome by Villamor, N, Conde, L, Martínez-Trillos, A, Cazorla, M, Navarro, A, Beà, S, López, C, Colomer, D, Pinyol, M, Aymerich, M, Rozman, M, Abrisqueta, P, Baumann, T, Delgado, J, Giné, E, González-Díaz, M, Hernández, J M, Colado, E, Payer, A R, Rayon, C, Navarro, B, José Terol, M, Bosch, F, Quesada, V, Puente, X S, López-Otín, C, Jares, P, Pereira, A, Campo, E, López-Guillermo, A

“…NOTCH1 has been found recurrently mutated in a subset of patients with chronic lymphocytic leukemia (CLL). To analyze biological features and clinical impact…”
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Blastic Plasmacytoid Dendritic Cell Neoplasm: A Single-Center Experience. Clinical Characterization, Mutational Landscape, and Clinical Outcome of Patients Undergoing Hematopoietic Stem Cell Transplantation Intensive Therapy by Gil-Lianes, J., Mozas, P., Baumann, T., Combalia, A., Baliu-Piqué, C., García, A., Rovira, M., López-Guerra, M., Villamor, N., Colomer, D., Rozman, M., Esteve, J., Estrach, T.

“…Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and aggressive hematodermic neoplasm usually involving the skin. In this retrospective case…”
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International standardized approach for flow cytometric residual disease monitoring in chronic lymphocytic leukaemia by RAWSTRON, A. C, VILLAMOR, N, EVAN, P. A. S, NATKUNAM, Y, COUTRE, S. E, AVERY, E. D, RASSENTI, L. Z, KIPPS, T. J, CALIGARIS-CAPPIO, F, KNEBA, M, BYRD, J. C, HALLEK, M. J, RITGEN, M, MONTSERRAT, E, HILLMEN, P, BÖTTCHER, S, GHIA, P, ZEHNDER, J. L, LOZANSKI, G, COLOMER, D, MORENO, C, GEUNA, M

“…The eradication of minimal residual disease (MRD) in chronic lymphocytic leukaemia (CLL) predicts for improved outcome. However, the wide variety of MRD…”
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The γ-secretase inhibitor PF-03084014 combined with fludarabine antagonizes migration, invasion and angiogenesis in NOTCH1-mutated CLL cells by López-Guerra, M, Xargay-Torrent, S, Rosich, L, Montraveta, A, Roldán, J, Matas-Céspedes, A, Villamor, N, Aymerich, M, López-Otín, C, Pérez-Galán, P, Roué, G, Campo, E, Colomer, D

“…Targeting Notch signaling has emerged as a promising therapeutic strategy for chronic lymphocytic leukemia (CLL), especially for the poor prognostic subgroup…”
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Blastic Plasmacytoid Dendritic Cell Neoplasm: A Single-Center Experience. Clinical Characterization, Mutational Landscape, and Clinical Outcome of Patients Undergoing Hematopoietic Stem Cell Transplantation Intensive Therapy by Gil-Lianes, J., Mozas, P., Baumann, T., Combalia, A., Baliu-Piqué, C., García, A., Rovira, M., López-Guerra, M., Villamor, N., Colomer, D., Rozman, M., Esteve, J., Estrach, T.

“…Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and aggressive hematodermic neoplasm usually involving the skin. In this retrospective case…”
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Is chronic lymphocytic leukemia curable? A clinical case relapsing 21 years after allogeneic stem-cell transplantation by Rovira, M., Villamor, N., Cobo, F., Fernández-Aviles, F., López-Guerra, M. L., Guijarro, F., Baumann, T., Montserrat, E.

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Clinicobiological features and prognostic impact of diffuse large B-cell lymphoma component in the outcome of patients with previously untreated follicular lymphoma by Magnano, L., Balagué, O., Dlouhy, I., Rovira, J., Karube, K., Pinyol, M., Rivas-Delgado, A., Costa, D., Martínez-Trillos, A., González-Farre, B., Martínez-Pozo, A., Giné, E., Colomer, D., Delgado, J., Villamor, N., Campo, E., López-Guillermo, A.

“…The co-existence at diagnosis of follicular lymphoma (FL) and diffuse large B-cell lymphoma (DLBCL) components (FL/DLBCL) has been considered a transformed…”
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The Follicular Lymphoma International Prognostic Index (FLIPI) and the histological subtype are the most important factors to predict histological transformation in follicular lymphoma by Giné, E, Montoto, S, Bosch, F, Arenillas, L, Mercadal, S, Villamor, N, Martínez, A, Colomo, L, Campo, E, Montserrat, E, López-Guillermo, A

“…Background: Histological transformation (HT) is a well-known event in patients with follicular lymphoma (FL) conferring an unfavorable prognosis. The aim of…”
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IMMUNE PROFILE IN THE PERIPHERAL BLOOD (PB) OF PATIENTS WITH FOLLICULAR LYMPHOMA (FL) AT DIAGNOSIS AND UPON RELAPSE by Rivero, A., Mozas, P., Correa, J., Araujo‐Ayala, F., Bataller, A., Rivas‐Delgado, A., Oliver‐Caldes, A., Perez‐Valencia, A., Gaya, A., Delgado, J., Giné, E., Perez‐Galan, P., Vlagea, A., Matutes, E., Villamor, N., López‐Guillermo, A., Magnano, L.

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Chronic lymphocytic leukemia in the elderly: clinico-biological features, outcomes, and proposal of a prognostic model by Baumann, Tycho, Delgado, Julio, Santacruz, Rodrigo, Martínez-Trillos, Alejandra, Royo, Cristina, Navarro, Alba, Pinyol, Magda, Rozman, María, Pereira, Arturo, Villamor, Neus, Aymerich, Marta, López, Cristina, Carrió, Anna, Montserrat, Emili

“…We investigated the clinico-biological features, outcomes, and prognosis of 949 patients with chronic lymphocytic leukemia according to age. No biological…”
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Comparison of four prognostic scores in peripheral T-cell lymphoma by Gutiérrez-García, G., García-Herrera, A., Cardesa, T., Martínez, A., Villamor, N., Ghita, G., Martínez-Trillos, A., Colomo, L., Setoain, X., Rodríguez, S., Giné, E., Campo, E., López-Guillermo, A.

“…To compare the usefulness of four prognostic scores in patients with peripheral T-cell lymphoma (PTCL) from a single institution. One hundred twenty-one…”
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TESTICULAR LARGE B‐CELL LYMPHOMA IS GENETICALLY SIMILAR TO PRIMARY CENTRAL NERVOUS SYSTEM LYMPHOMA AND DISTINCT FROM NODAL DIFFUSE LARGE B‐CELL LYMPHOMA by Rivas‐Delgado, A., López, C., Clot, G., Nadeu, F., Grau, M., Frigola, G., Bosch, J., Radke, J., Ishaque, N., Alcoceba, M., Melendo, G. Tapia, Luizaga, L., Barcena, C., Kelleher, N., Villamor, N., Baumann, T., Muntañola, A., Sancho‐Cia, J. M., García‐Sancho, A. Martin, Gonzalez‐Barca, E., Karube, K., Salaverria, I., Enjuanes, A., Heppner, F. L., Siebert, R., Climent, F., Campo, E., Giné, E., López‐Guillermo, A., Beà, S.

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The phosphatidylinositol-3-kinase inhibitor NVP-BKM120 overcomes resistance signals derived from microenvironment by regulating the Akt/FoxO3a/Bim axis in chronic lymphocytic leukemia cells by Laia Rosich, Ifigènia Saborit-Villarroya, Mónica López-Guerra, Sílvia Xargay-Torrent, Arnau Montraveta, Marta Aymerich, Neus Villamor, Elias Campo, Patricia Pérez-Galán, Gaël Roué, Dolors Colomer

“…Phosphatidylinositol-3-kinase pathway is constitutively activated in chronic lymphocytic leukemia mainly due to microenvironment signals, including stromal…”
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BCL-2 phosphorylation modulates sensitivity to the BH3 mimetic GX15-070 (Obatoclax) and reduces its synergistic interaction with bortezomib in chronic lymphocytic leukemia cells by Pérez-Galán, P, Roué, G, López-Guerra, M, Nguyen, M, Villamor, N, Montserrat, E, Shore, G C, Campo, E, Colomer, D

“…Chronic lymphocytic leukemia (CLL) is a B-cell lymphoid neoplasm with deregulated apoptosis and overexpression of several antiapoptotic BCL-2 proteins…”
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