Search Results - "Villaluz, Mark"

Snapshots of ligand entry, malleable binding and induced helical movement in P-glycoprotein by Szewczyk, Paul, Tao, Houchao, McGrath, Aaron P., Villaluz, Mark, Rees, Steven D., Lee, Sung Chang, Doshi, Rupak, Urbatsch, Ina L., Zhang, Qinghai, Chang, Geoffrey

“…P‐glycoprotein (P‐gp) is a transporter of great clinical and pharmacological significance. Several structural studies of P‐gp and its homologs have provided…”
Get full text

Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain by Ward, Andrew B., Szewczyk, Paul, Grimard, Vinciane, Lee, Chang-Wook, Martinez, Lorena, Doshi, Rupak, Caya, Alexandra, Villaluz, Mark, Pardon, Els, Cregger, Cristina, Swartz, Douglas J., Falson, Pierre Guy, Urbatsch, Ina L., Govaerts, Cedric, Steyaert, Jan, Chang, Geoffrey

“…P-glycoprotein (P-gp) is one of the best-known mediators of drug efflux-based multidrug resistance in many cancers. This validated therapeutic target is a…”
Get full text