Search Results - "Villalba, Jose Manuel"

Regulation of coenzyme Q biosynthesis pathway in eukaryotes by Villalba, José Manuel, Navas, Plácido

“…Coenzyme Q (CoQ, ubiquinone/ubiquinol) is a ubiquitous and unique molecule that drives electrons in mitochondrial respiratory chain and an obligatory step for…”
Get full text

Unprecedented Ring-Ring Interconversion of N,P,C-Cage Ligands by Villalba Franco, José Manuel, Schnakenburg, Gregor, Espinosa Ferao, Arturo, Streubel, Rainer

“…The novel N,P,C‐cage complexes 5 a–f and 6 a–f have been obtained by the reaction of the P‐pentamethylcyclopentadienylphosphinidene complex 2, generated…”
Get full text

Stimuli-Responsive Frustrated Lewis-Pair-Type Reactivity of a Tungsten Iminoazaphosphiridine Complex by Villalba Franco, José Manuel, Schnakenburg, Gregor, Sasamori, Takahiro, Espinosa Ferao, Arturo, Streubel, Rainer

“…Reactions of 3‐imino‐azaphosphiridine complexes 1 a,b with carbodiimides 2 a,b, isocyanates 3 a,b, and carbon dioxide are described. Whereas exchange of the…”
Get full text

Protective Role of Nrf2 in Renal Disease by Guerrero-Hue, Melania, Rayego-Mateos, Sandra, Vázquez-Carballo, Cristina, Palomino-Antolín, Alejandra, García-Caballero, Cristina, Opazo-Rios, Lucas, Morgado-Pascual, José Luis, Herencia, Carmen, Mas, Sebastián, Ortiz, Alberto, Rubio-Navarro, Alfonso, Egea, Javier, Villalba, José Manuel, Egido, Jesús, Moreno, Juan Antonio

“…Chronic kidney disease (CKD) is one of the fastest-growing causes of death and is predicted to become by 2040 the fifth global cause of death. CKD is…”
Get full text

The importance of plasma membrane coenzyme Q in aging and stress responses by Navas, Plácido, Villalba, José Manuel, de Cabo, Rafael

“…The plasma membrane of eukaryotic cells is the limit to interact with the environment. This position implies receiving stress signals that affects its…”
Get full text

Synthesis, Structure, and First Reactivity Studies of Functional (Phosphinoamino)boranes by Majhi, Paresh Kumar, Franco, José Manuel Villalba, Schnakenburg, Gregor, Sasamori, Takahiro, Streubel, Rainer

“…Functional phosphanes having a P–N–B motif were obtained by treatment of chloro(organo)phosphanes with boryl amides. Compounds 4a–e are stable up to 100 °C and…”
Get full text

Proteomic analysis of acute myeloid leukemia: Identification of potential early biomarkers and therapeutic targets by López-Pedrera, Chary, Villalba, José Manuel, Siendones, Emilio, Barbarroja, Nuria, Gómez-Díaz, Consuelo, Rodríguez-Ariza, Antonio, Buendía, Paula, Torres, Antonio, Velasco, Francisco

“…The main goal of this study was to analyze, using proteomic techniques, changes in protein expression of acute myeloid leukemia (AML) cells that could give…”
Get full text

Anti-dsDNA Antibodies Increase the Cardiovascular Risk in Systemic Lupus Erythematosus Promoting a Distinctive Immune and Vascular Activation by Patiño-Trives, Alejandra María, Pérez-Sánchez, Carlos, Pérez-Sánchez, Laura, Luque-Tévar, María, Ábalos-Aguilera, M. Carmen, Alcaide-Ruggiero, Lourdes, Arias-de la Rosa, Iván, Román-Rodríguez, Cristóbal, Seguí, Pedro, Espinosa, Mario, Font, Pilar, Barbarroja, Nuria, Escudero-Contreras, Alejandro, Antonio González-Reyes, José, Manuel Villalba, José, Collantes-Estévez, Eduardo, Aguirre-Zamorano, M. Ángeles, López-Pedrera, Chary

“…ObjectiveSystemic lupus erythematosus (SLE) is associated to boosted atherosclerosis development and a higher cardiovascular disease risk. This study aimed to…”
Get full text

Nox4 is involved in acute kidney injury associated to intravascular hemolysis by García-Caballero, Cristina, Guerrero-Hue, Melania, Vallejo-Mudarra, Mercedes, Palomino Antolin, Alejandra, Decouty-Pérez, Celine, Sánchez-Mendoza, Luz Marina, Villalba, José Manuel, González-Reyes, José Antonio, Opazo-Rios, Lucas, Vázquez-Carballo, Cristina, Herencia, Carmen, Leiva-Cepas, Fernando, Cortegano, Isabel, Andrés, Belén de, Egido, Jesús, Egea, Javier, Moreno, Juan Antonio

“…Massive intravascular hemolysis occurs not unfrequently in many clinical conditions. Breakdown of erythrocytes promotes the accumulation of heme-derivates in…”
Get full text

Ubiquinol Effects on Antiphospholipid Syndrome Prothrombotic Profile: A Randomized, Placebo-Controlled Trial by Pérez-Sánchez, Carlos, Aguirre, María Ángeles, Ruiz-Limón, Patricia, Abalos-Aguilera, María Carmen, Jiménez-Gómez, Yolanda, Arias-de la Rosa, Iván, Rodriguez-Ariza, Antonio, Fernández-del Río, Lucía, Gonzalez-Reyes, José Antonio, Segui, Pedro, Collantes-Estévez, Eduardo, Barbarroja, Nuria, Velasco, Francisco, Sciascia, Savino, Cecchi, Irene, Cuadrado, María José, Villalba, José Manuel, López-Pedrera, Chary

“…OBJECTIVE—Antiphospholipid syndrome (APS) leukocytes exhibit an oxidative perturbation, directly linked to alterations in mitochondrial dynamics and…”
Get full text

Selenium-Substituted Phosphaalk­enes Obtained through 1,2-Elimination of Chlorosilanes from Selenen­ylchlorophosphines by Sasamori, Takahiro, Villalba Franco, José Manuel, Guo, Jing-Dong, Sugamata, Koh, Nagase, Shigeru, Streubel, Rainer, Tokitoh, Norihiro

“…Stable selenenyl‐chlorophosphines, bearing a silylalkyl group, were synthesized. Subsequent treatment with Lewis acids such as AlCl3 afforded the corresponding…”
Get full text

Cdkn1a transcript variant 2 is a marker of aging and cellular senescence by López-Domínguez, José Alberto, Rodríguez-López, Sandra, Ahumada-Castro, Ulises, Desprez, Pierre-Yves, Konovalenko, Maria, Laberge, Remi-Martin, Cárdenas, César, Villalba, José Manuel, Campisi, Judith

“…Cellular senescence is a cell fate response characterized by a permanent cell cycle arrest driven primarily the by cell cycle inhibitor and tumor suppressor…”
Get full text

Preclinical Characterization of Pharmacologic NAD + Boosting as a Promising Therapeutic Approach in Rheumatoid Arthritis by Perez-Sanchez, Carlos, Escudero-Contreras, Alejandro, Cerdó, Tomás, Sánchez-Mendoza, Luz Marina, Llamas-Urbano, Adrián, la Rosa, Iván Arias-de, Pérez-Rodriguez, Miguel, Muñoz-Barrera, Laura, Del Carmen Abalos-Aguilera, María, Barbarroja, Nuria, Calvo, Jerusalem, Ortega-Castro, Rafaela, Ruiz-Vilchez, Desiree, Moreno, Juan Antonio, Burón, María Isabel, González-Reyes, José Antonio, Collantes-Estevez, Eduardo, Lopez-Pedrera, Chary, Villalba, José Manuel

“…We analyzed NAD metabolism in patients with rheumatoid arthritis (RA), its association with disease activity and clinical outcomes of RA, and the therapeutic…”
Get full text

Atherosclerosis and cardiovascular disease in systemic lupus erythematosus: effects of in vivo statin treatment by Ruiz-Limon, Patricia, Barbarroja, Nuria, Perez-Sanchez, Carlos, Aguirre, Maria Angeles, Bertolaccini, Maria Laura, Khamashta, Munther A, Rodriguez-Ariza, Antonio, Almadén, Yolanda, Segui, Pedro, Khraiwesh, Husam, Gonzalez-Reyes, Jose Antonio, Villalba, Jose Manuel, Collantes-Estevez, Eduardo, Cuadrado, Maria Jose, Lopez-Pedrera, Chary

“…Statins may have beneficial vascular effects in systemic lupus erythematosus (SLE) beyond their cholesterol-lowering action, although the mechanisms involved…”
Get more information

Mitochondrial dysfunction in antiphospholipid syndrome: implications in the pathogenesis of the disease and effects of coenzyme Q10 treatment by Perez-Sanchez, Carlos, Ruiz-Limon, Patricia, Aguirre, Maria Angeles, Bertolaccini, Maria Laura, Khamashta, Munther A., Rodriguez-Ariza, Antonio, Segui, Pedro, Collantes-Estevez, Eduardo, Barbarroja, Nuria, Khraiwesh, Husam, Gonzalez-Reyes, Jose Antonio, Villalba, Jose Manuel, Velasco, Francisco, Cuadrado, Maria Jose, Lopez-Pedrera, Chary

“…The exact mechanisms underlying the role of oxidative stress in the pathogenesis and the prothrombotic or proinflammatory status of antiphospholipid syndrome…”
Get full text

Metabolic and mitochondria alterations induced by SARS‐CoV‐2 accessory proteins ORF3a, ORF9b, ORF9c and ORF10 by López‐Ayllón, Blanca D., Marin, Silvia, Fernández, Marco Fariñas, García‐García, Tránsito, Fernández‐Rodríguez, Raúl, Lucas‐Rius, Ana, Redondo, Natalia, Mendoza‐García, Laura, Foguet, Carles, Grigas, Juozas, Calvet, Alba, Villalba, José Manuel, Gómez, María Josefa Rodríguez, Megías, Diego, Mandracchia, Biagio, Luque, Daniel, Lozano, Juan José, Calvo, Cristina, Herrán, Unai Merino, Thomson, Timothy M., Garrido, Juan J., Cascante, Marta, Montoya, María

“…Antiviral signaling, immune response and cell metabolism are dysregulated by SARS‐CoV‐2, the causative agent of COVID‐19. Here, we show that SARS‐CoV‐2…”
Get full text

Metabolic shift underlies tumor progression and immune evasion in S‐nitrosoglutathione reductase‐deficient cancer by Mena‐Osuna, Rafael, Mantrana, Ana, Guil‐Luna, Silvia, Sánchez‐Montero, María Teresa, Navarrete‐Sirvent, Carmen, Morales‐Ruiz, Teresa, Rivas‐Crespo, Aurora, Toledano‐Fonseca, Marta, García‐Ortíz, María Victoria, García‐Jurado, Gema, Gómez‐España, María Auxiliadora, González‐Fernández, Rafael, Villar, Carlos, Medina‐Fernández, Francisco Javier, Villalba, José Manuel, Aranda, Enrique, Rodríguez‐Ariza, Antonio

“…S‐nitrosoglutathione reductase (GSNOR) is a denitrosylase enzyme that has been suggested to play a tumor suppressor role, although the mechanisms responsible…”
Get full text

Enhanced NETosis generation in radiographic axial spondyloarthritis: utility as biomarker for disease activity and anti-TNF-α therapy effectiveness by Ruiz-Limon, Patricia, Ladehesa-Pineda, Maria Lourdes, Castro-Villegas, Maria Del Carmen, Abalos-Aguilera, Maria Del Carmen, Lopez-Medina, Clementina, Lopez-Pedrera, Chary, Barbarroja, Nuria, Espejo-Peralbo, Daniel, Gonzalez-Reyes, Jose Antonio, Villalba, Jose Manuel, Perez-Sanchez, Carlos, Escudero-Contreras, Alejandro, Collantes-Estevez, Eduardo, Font-Ugalde, Pilar, Jimenez-Gomez, Yolanda

“…Radiographic axial spondyloarthritis (r-axSpA) is a chronic inflammatory form of arthritis in which tumor necrosis factor (TNF)-α, a potent inducer of…”
Get full text

Regulation of hepatic coenzyme Q biosynthesis by dietary omega-3 polyunsaturated fatty acids by Fernández-del-Río, Lucía, Rodríguez-López, Sandra, Gutiérrez-Casado, Elena, González-Reyes, José Antonio, Clarke, Catherine F., Burón, María Isabel, Villalba, José Manuel

“…Dietary fats are important for human health, yet it is not fully understood how different fats affect various health problems. Although polyunsaturated fatty…”
Get full text

The influence of dietary fat source on liver and skeletal muscle mitochondrial modifications and lifespan changes in calorie-restricted mice by Villalba, José Manuel, López-Domínguez, José Alberto, Chen, Yana, Khraiwesh, Husam, González-Reyes, José Antonio, del Río, Lucía Fernández, Gutiérrez-Casado, Elena, del Río, Mercedes, Calvo-Rubio, Miguel, Ariza, Julia, de Cabo, Rafael, López-Lluch, Guillermo, Navas, Plácido, Hagopian, Kevork, Burón, María Isabel, Ramsey, Jon Jay

“…The Membrane Theory of Aging proposes that lifespan is inversely related to the level of unsaturation in membrane phospholipids. Calorie restriction (CR)…”
Get full text