Search Results - "Villalón, C M"

Olcegepant blocks neurogenic and non‐neurogenic CGRPergic vasodepressor responses and facilitates noradrenergic vasopressor responses in pithed rats by Avilés‐Rosas, V H, Rivera‐Mancilla, E, Marichal‐Cancino, B A, Manrique‐Maldonado, G, Altamirano‐Espinoza, A H, Maassen Van Den Brink, A, Villalón, C M

“…Background and Purpose Olcegepant (BIBN4096BS) is a selective non‐peptide CGRP receptor antagonist with acute antimigraine properties. Since systemic vascular…”
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Is CGRP Receptor Blockade Cardiovascularly Safe? Appropriate Studies Are Needed by Maassen van den Brink, A., Rubio‐Beltrán, E., Duncker, D., Villalón, C.M.

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Development of an experimental model to study trigeminal nerve-mediated vasodilation on the human forehead by Ibrahimi, K, Vermeersch, S, Danser, Ahj, Villalón, C M, van den Meiracker, A H, de Hoon, J, MaassenVanDenBrink, A

“…During migraine, trigeminal sensory nerve terminals release calcitonin gene-related peptide (CGRP), inducing nociception and vasodilation. Applied on the skin,…”
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Effects of ionotropic glutamate receptor antagonists on rat dural artery diameter in an intravital microscopy model by Chan, KY, Gupta, S, de Vries, R, Danser, AHJ, Villalón, CM, Muñoz‐Islas, E, MaassenVanDenBrink, A

“…Background and purpose:  During migraine, trigeminal nerves may release calcitonin gene‐related peptide (CGRP), inducing cranial vasodilatation and central…”
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The role of peripheral 5-HT1A , 5-HT1B , 5-HT1D , 5-HT1E and 5-HT1F serotonergic receptors in the reduction of nociception in rats by Granados-Soto, V, Argüelles, C.F, Rocha-González, H.I, Godínez-Chaparro, B, Flores-Murrieta, F.J, Villalón, C.M

“…Abstract This study assessed the possible antinociceptive role of peripheral 5-HT1 receptor subtypes in the rat formalin test. Rats were injected into the…”
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Pharmacological profile of the clonidine‐induced inhibition of vasodepressor sensory outflow in pithed rats: correlation with α2A/2C‐adrenoceptors by Villalón, C M, Albarrán‐Juárez, J A, Lozano‐Cuenca, J, Pertz, H H, Görnemann, T, Centurión, D

“…Background and purpose: Resistance blood vessels are innervated by sympathetic and primary sensory nerves, which modulate vascular tone through the release of…”
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Experimental migraine models and their relevance in migraine therapy by Arulmani, U, Gupta, S, VanDenBrink, A Maassen, Centurión, D, Villalón, C M, Saxena, P R

“…Although the understanding of migraine pathophysiology is incomplete, it is now well accepted that this neurovascular syndrome is mainly due to a cranial…”
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Evidence that some imidazoline derivatives inhibit peripherally the vasopressor sympathetic outflow in pithed rats by Monroy-Ordoñez, E.B, Villalón, C.M, Cobos-Puc, L.E, Márquez-Conde, J.A, Sánchez-López, A, Centurión, D

“…Abstract Imidazoline derivatives (e.g. clonidine and moxonidine) and α2 -adrenoceptor agonists (e.g. B-HT 933) have been shown to inhibit…”
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Pharmacological aspects of experimental headache models in relation to acute antimigraine therapy by De Vries, Peter, Villalón, Carlos M, Saxena, Pramod R

“…The last decade has witnessed a tremendous progress in the acute therapy of migraine, with sumatriptan, belonging to a new class of drugs, now known as 5-HT…”
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Donitriptan, but not sumatriptan, inhibits capsaicin‐induced canine external carotid vasodilatation via 5‐HT1B rather than 5‐HT1D receptors by Muñoz‐Islas, E, Gupta, S, Jiménez‐Mena, L R, Lozano‐Cuenca, J, Sánchez‐López, A, Centurión, D, Mehrotra, S, MaassenVanDenBrink, A, Villalón, C M

“…Background and purpose: It has been suggested that during a migraine attack capsaicin‐sensitive trigeminal sensory nerves release calcitonin gene‐related…”
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Possible role of alpha-adrenoceptor subtypes in acute migraine therapy by Willems, E W, Valdivia, L F, Villalón, C M, Saxena, P R

“…Even though the underlying mechanisms for the pathophysiology of migraine attacks are not completely understood, little doubt exists that the headache phase is…”
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5-HT1-like receptors: a time to bid goodbye by Saxena, P R, De Vries, P, Villalón, C M

“…It is exactly half a century ago that 5-hydroxytryptamine was discovered and over four decades ago two types of 5-HT receptors were described. In this article,…”
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Effects of sumatriptan on capsaicin-induced carotid haemodynamic changes and CGRP release in anaesthetized pigs by Arulmani, U, Heiligers, J P C, Garrelds, I M, Sánchez-López, A, Willems, E W, Villalón, C M, Saxena, P R

“…It is suggested that during a migraine attack capsaicin-sensitive trigeminal sensory nerves release calcitonin gene related peptide (CGRP), resulting in…”
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The role of dopamine D 2 , but not D 3 or D 4 , receptor subtypes, in quinpirole‐induced inhibition of the cardioaccelerator sympathetic outflow in pithed rats by Altamirano‐Espinoza, A H, González‐Hernández, A, Manrique‐Maldonado, G, Marichal‐Cancino, B A, Ruiz‐Salinas, I, Villalón, C M

“…Background and Purpose Quinpirole (a dopamine D 2 ‐like receptor agonist) inhibits the cardioaccelerator sympathetic outflow in pithed rats by…”
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The role of dopamine D2, but not D3 or D4, receptor subtypes, in quinpirole‐induced inhibition of the cardioaccelerator sympathetic outflow in pithed rats by Altamirano-Espinoza, A H, Gonzalez-Hernandez, A, Manrique-Maldonado, G, Marichal-Cancino, B A, Ruiz-Salinas, I, Villalon, C M

“…Background and Purpose Quinpirole (a dopamine D2‐like receptor agonist) inhibits the cardioaccelerator sympathetic outflow in pithed rats by sympathoinhibitory…”
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Assessment of anti-migraine potential of a novel alpha-adrenoceptor agonist S19014: effects on porcine carotid and regional haemodynamics and human coronary artery by Kapoor, K, Willems, E W, Maassen VanDenBrink, A, Heiligers, J P C, Cordi, A A, Vayssettes-Courchay, C, Verbeuren, T J, Villalón, C M, Saxena, P R

“…Taking into account the drawbacks associated with the use of triptans, attempts are being made to explore other avenues for the treatment of migraine…”
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Lack of effect of the adenosine A1 receptor agonist, GR79236, on capsaicin-induced CGRP release in anaesthetized pigs by Arulmani, U, Heiligers, J P C, Centurión, D, Garrelds, I M, Villalón, C M, Saxena, P R

“…Migraine is a common neurological disorder that is associated with an increase in plasma calcitonin gene-related peptide (CGRP) levels. CGRP, a potent…”
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Pharmacological profile of the receptors that mediate external carotid vasoconstriction by 5‐HT in vagosympathectomized dogs by Villalón, Carlos M., Juan, Eduardo Ramírez‐San, Castillo, Carlos, Castillo, Enrique, López‐Muñoz, Francisco J., Terrón, José A.

“…1 5‐Hydroxytryptamine (5‐HT) can produce vasodilatation or vasoconstriction of the canine external carotid bed depending upon the degree of carotid sympathetic…”
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Characterization of the postjunctional α 2C ‐adrenoceptor mediating vasoconstriction to UK14304 in porcine pulmonary veins by Görnemann, T, von Wenckstern, H, Kleuser, B, Villalón, C M, Centurión, D, Jähnichen, S, Pertz, H H

“…Background and purpose: In terms of postjunctional α 2 ‐adrenoceptors in the pulmonary circulation, no evidence is available with regard to the receptor…”
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Pharmacological profile of the clonidine-induced inhibition of vasodepressor sensory outflow in pithed rats: correlation with alpha(2A/2C)-adrenoceptors by Villalón, C M, Albarrán-Juárez, J A, Lozano-Cuenca, J, Pertz, H H, Görnemann, T, Centurión, D

“…Resistance blood vessels are innervated by sympathetic and primary sensory nerves, which modulate vascular tone through the release of noradrenaline and…”
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