Search Results - "Villa‐Morales, María"

Targeting the Fas/FasL signaling pathway in cancer therapy by Villa-Morales, María, Fernández-Piqueras, José

“…The Fas/FasL system plays a significant role in tumorigenesis. Research has shown that its impairment in cancer cells may lead to apoptosis resistance and…”
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The JAK3Q988P mutation reveals oncogenic potential and resistance to ruxolitinib by Lahera, Antonio, Vela‐Martín, Laura, Fernández‐Navarro, Pablo, Llamas, Pilar, López‐Lorenzo, José L., Cornago, Javier, Santos, Javier, Fernández‐Piqueras, José, Villa‐Morales, María

“…T‐cell acute lymphoblastic leukemia (T‐ALL) arises from the malignant transformation of T‐cell progenitors at various differentiation stages. Given that…”
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SOCS3 deregulation contributes to aberrant activation of the JAK/STAT pathway in precursor T‐cell neoplasms by Lahera, Antonio, López‐Nieva, Pilar, Alarcón, Hernán, Marín‐Rubio, José L., Cobos‐Fernández, María Á., Fernández‐Navarro, Pablo, Fernández, Agustín F., Vela‐Martín, Laura, Sastre, Isabel, Ruiz‐García, Sara, Llamas, Pilar, López‐Lorenzo, José L., Cornago, Javier, Santos, Javier, Fernández‐Piqueras, José, Villa‐Morales, María

“…Summary Despite the Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway being frequently altered in T‐ALL/LBL, no specific…”
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Identification of NRF2 Activation as a Prognostic Biomarker in T-Cell Acute Lymphoblastic Leukaemia by Villa-Morales, María, Pérez-Gómez, Laura, Pérez-Gómez, Eduardo, López-Nieva, Pilar, Fernández-Navarro, Pablo, Santos, Javier

“…The standard-of-care treatment of T-cell acute lymphoblastic leukaemia (T-ALL) with chemotherapy usually achieves reasonable rates of initial complete…”
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A Dual Role for FADD in Human Precursor T-Cell Neoplasms by Marín-Rubio, José Luis, Vela-Martín, Laura, Gudgeon, Jack, Pérez-Gómez, Eduardo, Sidgwick, Frances R, Trost, Matthias, Cunningham, Debbie L, Santos, Javier, Fernández-Piqueras, José, Villa-Morales, María

“…A reduction in levels has been reported in precursor T-cell neoplasms and other tumor types. Such reduction would impact on the ability of tumor cells to…”
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PIM1 is a potential therapeutic target for the leukemogenic effects mediated by JAK/STAT pathway mutations in T-ALL/LBL by Lahera, Antonio, Vela-Martín, Laura, Fernández-Navarro, Pablo, Llamas, Pilar, López-Lorenzo, José L., Cornago, Javier, Santos, Javier, Fernández-Piqueras, José, Villa-Morales, María

“…Precursor T-cell neoplasms (T-ALL/LBL) are aggressive hematological malignancies that arise from the malignant transformation of immature thymocytes. Despite…”
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RNA-Seq reveals the existence of a CDKN1C-E2F1-TP53 axis that is altered in human T-cell lymphoblastic lymphomas by López-Nieva, Pilar, Fernández-Navarro, Pablo, Vaquero-Lorenzo, Concepción, Villa-Morales, María, Graña-Castro, Osvaldo, Cobos-Fernández, María Ángeles, López-Lorenzo, José Luis, Llamas, Pilar, González-Sanchez, Laura, Sastre, Isabel, Pollan, Marina, Malumbres, Marcos, Santos, Javier, Fernández-Piqueras, José

“…Precursor T-cell lymphoblastic lymphomas (T-LBL) are rare aggressive hematological malignancies that mainly develop in children. As in other cancers, the loss…”
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A Role for Endoglin as a Suppressor of Malignancy during Mouse Skin Carcinogenesis by PEREZ-GOMEZ, Eduardo, VILLA-MORALES, Maria, SANTOS, Javier, FERNANDEZ-PIQUERAS, José, GAMALLO, Carlos, DOTOR, Javier, BERNABEU, Carmelo, QUINTANILLA, Miguel

“…Endoglin is a membrane glycoprotein that acts as a coreceptor for transforming growth factor-beta. We and others have previously suggested a function of…”
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Comprehensive characterization of a novel, oncogenic and targetable SEPTIN6::ABL2 fusion in T-ALL by Lahera, Antonio, Vela-Martín, Laura, López-Nieva, Pilar, Salgado, Rocío N, Rodríguez-Perales, Sandra, Torres-Ruiz, Raúl, López-Lorenzo, José L, Cornago, Javier, Llamas, Pilar, Fernández-Navarro, Pablo, Sánchez-Domínguez, Rebeca, Segovia, José C, Sastre, Isabel, Cobos-Fernández, María Á, Menéndez, Pablo, Santos, Javier, Fernández-Piqueras, José, Villa-Morales, María

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A Role for Stroma-Derived Annexin A1 as Mediator in the Control of Genetic Susceptibility to T-Cell Lymphoblastic Malignancies through Prostaglandin E2 Secretion by SANTOS, Javier, GONZILEZ-SINCHEZ, Laura, MONTAGUTELLI, Xavier, FERNANDEZ-PIQUERAS, José, MATABUENA-DEYZAGUIRRE, Maria, VILLA-MORALES, Maria, COZAR, Patricia, LOPEZ-NIEVA, Pilar, FERNANDEZ-NAVARRO, Pablo, FRESNO, Manuel, DIAZ-MUNOZ, Manuel D, GUENET, Jean-Louis

“…Cancer susceptibility is essentially attributable to multiple low-penetrance genes. Using interspecific consomic and congenic mice between the tumor-resistant…”
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S194-P-FADD as a marker of aggressiveness and poor prognosis in human T-cell lymphoblastic lymphoma by Marín-Rubio, José L, Pérez-Gómez, Eduardo, Fernández-Piqueras, José, Villa-Morales, María

“…Abstract T-cell lymphoblastic lymphoma is a haematological disease with an urgent need for reliable prognostic biomarkers that allow therapeutic stratification…”
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Detection of novel fusion-transcripts by RNA-Seq in T-cell lymphoblastic lymphoma by López-Nieva, Pilar, Fernández-Navarro, Pablo, Graña-Castro, Osvaldo, Andrés-León, Eduardo, Santos, Javier, Villa-Morales, María, Cobos-Fernández, María Ángeles, González-Sánchez, Laura, Malumbres, Marcos, Salazar-Roa, María, Fernández-Piqueras, José

“…Fusions transcripts have been proven to be strong drivers for neoplasia-associated mutations, although their incidence in T-cell lymphoblastic lymphoma needs…”
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A role for the Fas/FasL system in modulating genetic susceptibility to T-cell lymphoblastic lymphomas by VILLA-MORALES, Maria, SANTOS, Javier, PEREZ-GOMEZ, Eduardo, QUINTANILLA, Miguel, FERNANDEZ-PIQUERAS, José

“…The Fas/FasL system mediates induced apoptosis of immature thymocytes and peripheral T lymphocytes, but little is known about its implication in genetic…”
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FADD in Cancer: Mechanisms of Altered Expression and Function, and Clinical Implications by Marín-Rubio, José L, Vela-Martín, Laura, Fernández-Piqueras, José, Villa-Morales, María

“…FADD was initially described as an adaptor molecule for death receptor-mediated apoptosis, but subsequently it has been implicated in nonapoptotic cellular…”
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Downregulation of specific FBXW7 isoforms with differential effects in T-cell lymphoblastic lymphoma by Vázquez-Domínguez, Irene, González-Sánchez, Laura, López-Nieva, Pilar, Fernández-Navarro, Pablo, Villa-Morales, María, Cobos-Fernández, María Á., Sastre, Isabel, F. Fraga, Mario, F. Fernández, Agustín, Malumbres, Marcos, Salazar-Roa, María, Graña-Castro, Osvaldo, Santos, Javier, Llamas, Pilar, López-Lorenzo, José L., Fernández-Piqueras, José

“…FBXW7 is a driver gene in T-cell lymphoblastic neoplasia acting through proteasome degradation of key proto-oncogenes. FBXW7 encodes three isoforms, α, β and…”
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Down-regulation of specific miRNAs enhances the expression of the gene Smoothened and contributes to T-cell lymphoblastic lymphoma development by González-Gugel, Elena, Villa-Morales, María, Santos, Javier, Bueno, Maria José, Malumbres, Marcos, Rodríguez-Pinilla, Socorro María, Piris, Miguel Ángel, Fernández-Piqueras, José

“…Inappropriate activation of the GLI/hedgehog (GLI/Hh) signalling occurs in several human cancers, including haematological neoplasms. However, little is known…”
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EPHA7, a new target gene for 6q deletion in T-cell lymphoblastic lymphomas by López-Nieva, Pilar, Vaquero, Concepción, Fernández-Navarro, Pablo, González-Sánchez, Laura, Villa-Morales, María, Santos, Javier, Esteller, Manel, Fernández-Piqueras, José

“…Cryptic deletions at chromosome 6q are common cytogenetic abnormalities in T-cell lymphoblastic leukemia/lymphoma (T-LBL), but the target genes have not been…”
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The JAK3 Q988P mutation reveals oncogenic potential and resistance to ruxolitinib by Lahera, Antonio, Vela‐Martín, Laura, Fernández‐Navarro, Pablo, Llamas, Pilar, López‐Lorenzo, José L., Cornago, Javier, Santos, Javier, Fernández‐Piqueras, José, Villa‐Morales, María

“…Abstract T‐cell acute lymphoblastic leukemia (T‐ALL) arises from the malignant transformation of T‐cell progenitors at various differentiation stages. Given…”
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Deregulated FADD expression and phosphorylation in T-cell lymphoblastic lymphoma by Marín-Rubio, José L, de Arriba, María C, Cobos-Fernández, María A, González-Sánchez, Laura, Ors, Inmaculada, Sastre, Isabel, Fernández-Piqueras, José, Villa-Morales, María

“…In the present work, we show that T-cell lymphoblastic lymphoma cells exhibit a reduction of FADD availability in the cytoplasm, which may contribute to…”
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Role of cannabinoid receptor CB2 in HER2 pro-oncogenic signaling in breast cancer by Pérez-Gómez, Eduardo, Andradas, Clara, Blasco-Benito, Sandra, Caffarel, María M, García-Taboada, Elena, Villa-Morales, María, Moreno, Estefanía, Hamann, Sigrid, Martín-Villar, Ester, Flores, Juana M, Wenners, Antonia, Alkatout, Ibrahim, Klapper, Wolfram, Röcken, Christoph, Bronsert, Peter, Stickeler, Elmar, Staebler, Annette, Bauer, Maret, Arnold, Norbert, Soriano, Joaquim, Pérez-Martínez, Manuel, Megías, Diego, Moreno-Bueno, Gema, Ortega-Gutiérrez, Silvia, Artola, Marta, Vázquez-Villa, Henar, Quintanilla, Miguel, Fernández-Piqueras, José, Canela, Enric I, McCormick, Peter J, Guzmán, Manuel, Sánchez, Cristina

“…Pharmacological activation of cannabinoid receptors elicits antitumoral responses in different cancer models. However, the biological role of these receptors…”
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