Search Results - "Villa, Federico"

Extracellular Vesicles as Natural, Safe and Efficient Drug Delivery Systems by Villa, Federico, Quarto, Rodolfo, Tasso, Roberta

“…Extracellular vesicles (EVs) are particles naturally released from cells, delimited by a lipid bilayer, carrying functionally active biological molecules. In…”
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New drug pricing criteria in Italy: considerations and proposals to support value and innovation by Patarnello, Francesca, Villa, Federico

“…The definition of criteria and processes for the submission of price and reimbursement requests (P&R) of a drug in Italy cannot be separated from the…”
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Variables affecting pricing of orphan drugs: the Italian case by Jommi, Claudio, Listorti, Elisabetta, Villa, Federico, Ghislandi, Simone, Genazzani, Armando, Cangini, Agnese, Trotta, Francesco

“…Abstract Background and aim Evidence on determinants of prices for orphan medicines is scarce and not available for Italy. The aim of this paper is to provide…”
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Physical Characterization of Colorectal Cancer Spheroids and Evaluation of NK Cell Infiltration Through a Flow-Based Analysis by Sargenti, Azzurra, Musmeci, Francesco, Bacchi, Francesco, Delprete, Cecilia, Cristaldi, Domenico Andrea, Cannas, Federica, Bonetti, Simone, Pasqua, Simone, Gazzola, Daniele, Costa, Delfina, Villa, Federico, Zocchi, Maria Raffaella, Poggi, Alessandro

“…To improve pathogenetic studies in cancer development and reliable preclinical testing of anti-cancer treatments, three-dimensional (3D) cultures, including…”
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Value generated by the multiplier effect of investments by the pharmaceutical industry in Italy: proposals to promote competitiveness and attractiveness by Patarnello, Francesca, Briante, Emiliano, Villa, Federico

“…Pharmaceutical industry investments in Italy must be supported with a reform process that promotes simplifications to generate an attractive ecosystem that can…”
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Targeting PIK3CA Actionable Mutations in the Circulome: A Proof of Concept in Metastatic Breast Cancer by Cardinali, Barbara, De Luca, Giuseppa, Tasso, Roberta, Coco, Simona, Garuti, Anna, Buzzatti, Giulia, Sciutto, Andrea, Arecco, Luca, Villa, Federico, Carli, Franca, Reverberi, Daniele, Quarto, Rodolfo, Dono, Mariella, Del Mastro, Lucia

“…The study of circulating cancer-derived components (circulome) is considered the new frontier of liquid biopsy. Despite the recognized role of circulome…”
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Comprehensive Profiling of Secretome Formulations from Fetal- and Perinatal Human Amniotic Fluid Stem Cells by Costa, Ambra, Ceresa, Davide, De Palma, Antonella, Rossi, Rossana, Turturo, Sara, Santamaria, Sara, Balbi, Carolina, Villa, Federico, Reverberi, Daniele, Cortese, Katia, De Biasio, Pierangela, Paladini, Dario, Coviello, Domenico, Ravera, Silvia, Malatesta, Paolo, Mauri, Pierluigi, Quarto, Rodolfo, Bollini, Sveva

“…We previously reported that c-KIT+ human amniotic-fluid derived stem cells obtained from leftover samples of routine II trimester prenatal diagnosis (fetal…”
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Targeting of colorectal cancer organoids with zoledronic acid conjugated to the anti-EGFR antibody cetuximab by Benelli, Roberto, Costa, Delfina, Salvini, Laura, Tardito, Samuele, Tosetti, Francesca, Villa, Federico, Zocchi, Maria Raffaella, Poggi, Alessandro

“…Antibody-drug conjugates (ADC) are essential therapeutic options to treat solid and hematological cancers. The anti-epidermal growth factor-receptor (EGFR)…”
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Challenging Giant Insular Gliomas With Brain Mapping: Evaluation of Neurosurgical, Neurological, Neuropsychological, and Quality of Life Results in a Large Mono-Institutional Series by Rossi, Marco, Gay, Lorenzo, Conti Nibali, Marco, Sciortino, Tommaso, Ambrogi, Federico, Leonetti, Antonella, Puglisi, Guglielmo, Howells, Henrietta, Zito, Paola, Villa, Federico, Ciroi, Gjulio, Riva, Marco, Bello, Lorenzo

“…Giant insular tumors are commonly not amenable to complete resection and are associated with a high postoperative morbidity rate. Transcortical approach and…”
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The treament of hyperglycemia in acute ischemic stroke with incretin-based drugs by Ferrari, Federica, Moretti, Antonio, Villa, Roberto Federico

“…[Display omitted] Stroke is a major cause of mortality and morbidity worldwide. Considerable experimental and clinical evidence suggests that both diabetes…”
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Circulating healing (CH) cells expressing BST2 are functionally activated by the injury-regulated systemic factor HGFA by Lo Sicco, Claudia, Reverberi, Daniele, Villa, Federico, Pfeffer, Ulrich, Quarto, Rodolfo, Cancedda, Ranieri, Tasso, Roberta

“…Restoration of damaged tissues through the activation of endogenous progenitors is an attractive therapeutic option. A deep evaluation of the intrinsic…”
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Hyperglycemia in acute ischemic stroke: physiopathological and therapeutic complexity by Ferrari, Federica, Moretti, Antonio, Villa, Roberto

“…Diabetes mellitus and associated chronic hyperglycemia enhance the risk of acute ischemic stroke and lead to worsened clinical outcome and increased mortality…”
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Hemodynamic management of acute brain injury caused by cerebrovascular diseases: a survey of the European Society of Intensive Care Medicine by Messina, Antonio, Villa, Federico, Lionetti, Giulia, Galarza, Laura, Meyfroidt, Geert, van der Jagt, Mathieu, Monnet, Xavier, Pelosi, Paolo, Cecconi, Maurizio, Robba, Chiara

“…Background The optimal hemodynamic targets and management of patients with acute brain injury are not completely elucidated, but recent evidence points to…”
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Orphan Drug Prices and Epidemiology of Rare Diseases: A Cross-Sectional Study in Italy in the Years 2014-2019 by Villa, Federico, Di Filippo, Aurora, Pierantozzi, Andrea, Genazzani, Armando, Addis, Antonio, Trifirò, Gianluca, Cangini, Agnese, Tafuri, Giovanni, Settesoldi, Daniela, Trotta, Francesco

“…It is well acknowledged that the price of orphan drugs is normally higher than that resulting from the value-based pricing. A correlation between the cost of…”
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Accesso precoce al mercato: dalle approvazioni condizionate di EMA agli accordi negoziali particolari di AIFA by Villa, Federico, Jommi, Claudio, Genazzani, Armando, Antignani, Sara, Montilla, Simona, Melazzini, Mario

“…The European Medicines Agency (EMA) has adopted assessment systems and drug registration procedures to respond to the needs for rapid patient access to…”
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The Murine PSE/TATA-dependent transcriptome: evidence of functional homologies with its human counterpart by Bruzzone, Maria Jessica, Gavazzo, Paola, Massone, Sara, Balbi, Carolina, Villa, Federico, Conti, Anastasia, Dieci, Giorgio, Cancedda, Ranieri, Pagano, Aldo

“…A series of recent studies demonstrated an unexpectedly high frequency of intronic RNA polymerase (pol) III transcription units spread throughout the human…”
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Closed system endotracheal suctioning maintains lung volume during volume-controlled mechanical ventilation by CEREDA, Maurizio, VILLA, Federico, COLOMBO, Enrico, GRECO, Gianluca, NACOTI, Mirco, PESENTI, Antonio

“…A closed suction system (CS) maintains connection with the mechanical ventilator during tracheal suctioning and is claimed to limit loss in lung volume and…”
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Challenges in the hemodynamic management of acute nontraumatic neurological injuries by Messina, Antonio, Villa, Federico, Cecconi, Maurizio

“…To appraise the evidence from the literature and suggest an integrated hemodynamic approach of early and delayed phases of acute ischemic stroke (AIS),…”
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Challenges in the hemodynamic management of acute nontraumatic neurological injuries by Messina, Antonio, Villa, Federico, Cecconi, Maurizio

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Nuovi criteri di definizione del prezzo di un farmaco in Italia: riflessioni e proposte per supportare valore ed innovazione by Patarnello, Francesca, Villa, Federico

“…The definition of criteria and processes for the submission of price and reimbursement requests (P&R) of a drug in Italy cannot be separated from the…”
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