Evolution of Lipid Profiles after Bariatric Surgery

Background The most commonly encountered dyslipidemia in obese individuals is characterized by a cluster of interrelated plasma lipid and lipoprotein abnormalities including hypertriglyceridemia, low HDL cholesterol values, and increased small, dense LDL cholesterol particles. The aim of this study...

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Published in:	Obesity surgery Vol. 22; no. 4; pp. 609 - 616
Main Authors:	Garcia-Marirrodriga, Ignacio, Amaya-Romero, Cesar, Ruiz-Diaz, Gabriel Patiño, Férnandez, Sandra, Ballesta-López, Carlos, Pou, Jose Ma, Romeo, June H., Vilhur, Gemma, Badimon, Lina, Ybarra, Juan
Format:	Journal Article
Language:	English
Published:	New York Springer-Verlag 01-04-2012 Springer Nature B.V
Subjects:	Adult Analysis of Variance Cholesterol, HDL - blood Cholesterol, LDL - blood Clinical Research Female Follow-Up Studies Gastric Bypass - methods Gastrointestinal surgery Humans Hyperlipidemias - blood Hyperlipidemias - epidemiology Lipids Lipids - blood Male Medicine Medicine & Public Health Middle Aged Obesity Obesity, Morbid - blood Obesity, Morbid - epidemiology Pilot Projects Postoperative Period Preoperative Period Retrospective Studies Spain - epidemiology Surgery Treatment Outcome Triglycerides - blood Weight Loss Young Adult Spain Lipoprotein sub-fractions Bariatric surgery Morbid obesity
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Summary:	Background The most commonly encountered dyslipidemia in obese individuals is characterized by a cluster of interrelated plasma lipid and lipoprotein abnormalities including hypertriglyceridemia, low HDL cholesterol values, and increased small, dense LDL cholesterol particles. The aim of this study was to assess the changes in lipid profiles at baseline (pre-operatively) and at follow-up (6, 12, and 18 months) after a laparoscopic Roux-en-Y gastric bypass (LRYGBP). A retrospective observational study was performed involving all patients who consecutively underwent a LRYGBP between January 1, 2007 and December 31, 2009. Fasting lipids sub-fractions (total cholesterol, LDL cholesterol, HDL cholesterol, and triglycerides) were measured and HOMA-IR calculated pre-operatively and at follow-up post-LRYGBP. Pearson’s correlation coefficients were used to assess the relationship between excess weight loss (EWL) and lipid sub-fractions. ANOVA was used to assess the differences between each lipid sub-fraction at various time-points. Methods One hundred twenty eight ( N = 128) medical charts were reviewed, and those containing data on lipid fractions at the three follow-up time-points were analyzed. One hundred fourteen patients ( N = 114), 84 of whom were women (73.7%), were finally included in the study. Results Total cholesterol, LDL cholesterol, triglycerides, and HOMA-IR were significantly reduced after LRYGBP ( P < 0.0005 for all). Inversely, HDL cholesterol disclosed a significant rise ( P < 0.0005). Noteworthy significant associations between lipid subfractions and EWL were detected overall ( P < 0.0005 for all). A gender effect was found since female patients displayed a milder association than male patients ( P < 0.0005). Conclusions LRYGBP-induced weight loss improves the lipid profile while reducing insulin resistance, with male patients showing a better profile than female patients.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0960-8923 1708-0428
DOI:	10.1007/s11695-011-0534-7