Search Results - "Vilette, Didier"

Wide distribution of prion infectivity in the peripheral tissues of vCJD and sCJD patients by Douet, Jean-Yves, Huor, Alvina, Cassard, Hervé, Lugan, Séverine, Aron, Naima, Arnold, Mark, Vilette, Didier, Torres, Juan-Maria, Ironside, James W., Andreoletti, Olivier

“…Sporadic Creutzfeldt-Jakob disease (sCJD) is the commonest human prion disease, occurring most likely as the consequence of spontaneous formation of abnormal…”
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Cells Release Prions in Association with Exosomes by Fevrier, Benoit, Vilette, Didier, Archer, Fabienne, Loew, Damarys, Faigle, Wolfgang, Vidal, Michel, Laude, Hubert, Raposo, Graça, De Camilli, Pietro V.

“…Prion diseases are infectious neurodegenerative disorders linked to the accumulation in the central nervous system of the abnormally folded prion protein (PrP)…”
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Preclinical detection of variant CJD and BSE prions in blood by Lacroux, Caroline, Comoy, Emmanuel, Moudjou, Mohammed, Perret-Liaudet, Armand, Lugan, Séverine, Litaise, Claire, Simmons, Hugh, Jas-Duval, Christelle, Lantier, Isabelle, Béringue, Vincent, Groschup, Martin, Fichet, Guillaume, Costes, Pierrette, Streichenberger, Nathalie, Lantier, Frederic, Deslys, Jean Philippe, Vilette, Didier, Andréoletti, Olivier

“…The emergence of variant Creutzfeldt Jakob Disease (vCJD) is considered a likely consequence of human dietary exposure to Bovine Spongiform Encephalopathy…”
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Efficient inhibition of infectious prions multiplication and release by targeting the exosomal pathway by Vilette, Didier, Laulagnier, Karine, Huor, Alvina, Alais, Sandrine, Simoes, Sabrina, Maryse, Romao, Provansal, Monique, Lehmann, Sylvain, Andreoletti, Olivier, Schaeffer, Laurent, Raposo, Graça, Leblanc, Pascal

“…Exosomes are secreted membrane vesicles of endosomal origin present in biological fluids. Exosomes may serve as shuttles for amyloidogenic proteins, notably…”
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Highly efficient prion transmission by blood transfusion by Andréoletti, Olivier, Litaise, Claire, Simmons, Hugh, Corbière, Fabien, Lugan, Séverine, Costes, Pierrette, Schelcher, François, Vilette, Didier, Grassi, Jacques, Lacroux, Caroline

“…It is now clearly established that the transfusion of blood from variant CJD (v-CJD) infected individuals can transmit the disease. Since the number of…”
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Prions from Sporadic Creutzfeldt-Jakob Disease Patients Propagate as Strain Mixtures by Cassard, Hervé, Huor, Alvina, Espinosa, Juan-Carlos, Douet, Jean-Yves, Lugan, Severine, Aron, Naima, Vilette, Didier, Delisle, Marie-Bernadette, Marín-Moreno, Alba, Peran, Patrice, Beringue, Vincent, Torres, Juan Maria, Ironside, James W, Andreoletti, Olivier

“…Sporadic Creutzfeldt-Jakob disease (sCJD) cases are currently classified according to the methionine/valine polymorphism at codon 129 of the gene and the…”
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Screening of 145 Anti-PrP Monoclonal Antibodies for Their Capacity to Inhibit PrPSc Replication in Infected Cells by Féraudet, Cécile, Morel, Nathalie, Simon, Stéphanie, Volland, Hervé, Frobert, Yveline, Créminon, Christophe, Vilette, Didier, Lehmann, Sylvain, Grassi, Jacques

“…Prion diseases are transmissible neurodegenerative disorders affecting humans and animals for which no therapeutic or prophylactic regimens exist. During the…”
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Prionemia and Leukocyte-Platelet-Associated Infectivity in Sheep Transmissible Spongiform Encephalopathy Models by LACROUX, Caroline, VILETTE, Didier, WEISBECKER, Jean-Louis, LANTIER, Isabelle, LANTIER, Frederic, SCHELCHER, François, GRASSI, Jacques, CASTILLA, Joaquin, ANDREOLETTI, Olivier, FERNANDEZ-BORGES, Natalia, LITAISE, Claire, LUGAN, Séverine, MOREL, Nathalie, CORBIERE, Fabien, SIMON, Stéphanie, SIMMONS, Hugh, COSTES, Pierrette

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Antihypertensive drug guanabenz is active in vivo against both yeast and mammalian prions by Tribouillard-Tanvier, Déborah, Béringue, Vincent, Desban, Nathalie, Gug, Fabienne, Bach, Stéphane, Voisset, Cécile, Galons, Hervé, Laude, Hubert, Vilette, Didier, Blondel, Marc

“…Prion-based diseases are incurable transmissible neurodegenerative disorders affecting animals and humans. Here we report the discovery of the in vivo…”
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Prion strains associated with iatrogenic CJD in French and UK human growth hormone recipients by Douet, Jean-Yves, Huor, Alvina, Cassard, Hervé, Lugan, Séverine, Aron, Naïma, Mesic, Chloé, Vilette, Didier, Barrio, Tomás, Streichenberger, Nathalie, Perret-Liaudet, Armand, Delisle, Marie-Bernadette, Péran, Patrice, Deslys, Jean-Philippe, Comoy, Emmanuel, Vilotte, Jean-Luc, Goudarzi, Katayoun, Béringue, Vincent, Barria, Marcelo A, Ritchie, Diane L, Ironside, James W, Andréoletti, Olivier

“…Treatment with human pituitary-derived growth hormone (hGH) was responsible for a significant proportion of iatrogenic Creutzfeldt-Jakob disease (iCJD) cases…”
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White blood cell-based detection of asymptomatic scrapie infection by ex vivo assays by Halliez, Sophie, Jaumain, Emilie, Huor, Alvina, Douet, Jean-Yves, Lugan, Séverine, Cassard, Hervé, Lacroux, Caroline, Béringue, Vincent, Andréoletti, Olivier, Vilette, Didier

“…Prion transmission can occur by blood transfusion in human variant Creutzfeldt-Jakob disease and in experimental animal models, including sheep. Screening of…”
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Expression of Prion Protein Increases Cellular Copper Binding and Antioxidant Enzyme Activities but Not Copper Delivery by Rachidi, Walid, Vilette, Didier, Guiraud, Pascale, Arlotto, Marie, Riondel, Jacqueline, Laude, Hubert, Lehmann, Sylvain, Favier, Alain

“…The N-terminal region of the prion protein PrP C contains a series of octapeptide repeats. This region has been implicated in the binding of divalent metal…”
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A simple, versatile and sensitive cell-based assay for prions from various species by Arellano-Anaya, Zaira E, Savistchenko, Jimmy, Mathey, Jacinthe, Huor, Alvina, Lacroux, Caroline, Andréoletti, Olivier, Vilette, Didier

“…Detection and quantification of prion infectivity is a crucial step for various fundamental and applied aspects of prion research. Identification of cell lines…”
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Recovery of Small Infectious PrPres Aggregates from Prion-infected Cultured Cells by Anaya, Zaira E. Arellano, Savistchenko, Jimmy, Massonneau, Véronique, Lacroux, Caroline, Andréoletti, Olivier, Vilette, Didier

“…Prion diseases are characterized by deposits of abnormal conformers of the PrP protein. Although large aggregates of proteinase K-resistant PrP (PrPres) are…”
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Protein folding activity of ribosomal RNA is a selective target of two unrelated antiprion drugs by Tribouillard-Tanvier, Déborah, Dos Reis, Suzana, Gug, Fabienne, Voisset, Cécile, Béringue, Vincent, Sabate, Raimon, Kikovska, Ema, Talarek, Nicolas, Bach, Stéphane, Huang, Chenhui, Desban, Nathalie, Saupe, Sven J, Supattapone, Surachai, Thuret, Jean-Yves, Chédin, Stéphane, Vilette, Didier, Galons, Hervé, Sanyal, Suparna, Blondel, Marc

“…6-Aminophenanthridine (6AP) and Guanabenz (GA, a drug currently in use for the treatment of hypertension) were isolated as antiprion drugs using a yeast-based…”
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Efficient dissemination of prions through preferential transmission to nearby cells by Paquet, Sophie, Langevin, Christelle, Chapuis, Jerome, Jackson, Graham S, Laude, Hubert, Vilette, Didier

“…1 Virologie et Immunologie Moléculaires, Institut National de la Recherche Agronomique, 78350 Jouy-en-Josas, France 2 MRC Prion Unit, Department of…”
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Exosomes: A Bubble Ride for Prions? by Février, Benoît, Vilette, Didier, Laude, Hubert, Raposo, Graça

“…In certain cell types, endosomal multivesicular bodies may fuse with the cell surface in an exocytic manner. During this process, the small 50–90‐nm‐diameter…”
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Infection of Cell Lines with Experimental and Natural Ovine Scrapie Agents by NEALE, Michael H, MOUNTJOY, Susan J, EDWARDS, Jane C, VILETTE, Didier, LAUDE, Hubert, WINDL, Otto, SAUNDERS, Ginny C

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Successful Transmission of Three Mouse-Adapted Scrapie Strains to Murine Neuroblastoma Cell Lines Overexpressing Wild-Type Mouse Prion Protein by Nishida, N, Harris, D A, Vilette, D, Laude, H, Frobert, Y, Grassi, J, Casanova, D, Milhavet, O, Lehmann, S

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PrPc Does Not Mediate Internalization of PrPSc but Is Required at an Early Stage for De Novo Prion Infection of Rov Cells by PAQUET, Sophie, DAUDE, Nathalie, COURAGEOT, Marie-Pierre, CHAPUIS, Jérome, LAUDE, Hubert, VILETTE, Didier

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