Diagnosis at different stages of paracoccidioidomycosis with oral manifestation: Report of two cases

Paracocciodiomycosis (PCDM) is a chronic systemic fungal infection, mainly affecting residents and rural workers, being characterized by a long incubation period, which it can take months or years without clinical manifestations, making diagnosis late and difficult. Depending on the stage of the dis...

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Bibliographic Details
Published in:	Journal de mycologie médicale Vol. 30; no. 4; p. 101025
Main Authors:	de Oliveira, M.S., Fernandes, T.B., de Lima Medeiros, Y., de Abreu Guimarães, L.D., Sanches, G.T., de Carvalho, M.F., Vilela, E.M.
Format:	Journal Article
Language:	English
Published:	France Elsevier Masson SAS 01-12-2020
Subjects:	Antifungal Agents - therapeutic use Disease Progression Humans Infection Itraconazole - therapeutic use Lung injury Male Middle Aged Mouth - microbiology Mouth - pathology Mouth - surgery Mouth Diseases - diagnosis Mouth Diseases - drug therapy Mouth Diseases - microbiology Mouth Diseases - surgery Oral diagnosis Paracoccidioidomycosis Paracoccidioidomycosis - diagnosis Paracoccidioidomycosis - drug therapy Paracoccidioidomycosis - pathology Paracoccidioidomycosis - surgery Radiography, Thoracic Respiratory Tract Infections - diagnosis Respiratory Tract Infections - drug therapy Respiratory Tract Infections - microbiology Respiratory Tract Infections - surgery Infection PAS Oral diagnosis Paracoccidioidomycosis PCDM mg kg Lung injury
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Summary:	Paracocciodiomycosis (PCDM) is a chronic systemic fungal infection, mainly affecting residents and rural workers, being characterized by a long incubation period, which it can take months or years without clinical manifestations, making diagnosis late and difficult. Depending on the stage of the disease, it can cause sequelae and low quality of life, so its correct diagnosis is of great importance for the accurate treatment. Therefore, the aim of this report is to present two cases of diagnosis of patients with PCDM at different stages, who developed chronic manifestations, pain, clinical involvement of the oral cavity and in one case also presented lung injury with fibrosis, as well as to weight loss, dysphagia and cachexia. Both of patients were treated with antifungal therapy and it was observed total remission of the lesions and no recurrences were detected.
Bibliography:	ObjectType-Case Study-2 SourceType-Scholarly Journals-1 ObjectType-Feature-4 content type line 23 ObjectType-Report-1 ObjectType-Article-3
ISSN:	1156-5233 1773-0449
DOI:	10.1016/j.mycmed.2020.101025