Search Results - "Vilches, José"
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SETD3 is an actin histidine methyltransferase that prevents primary dystocia
Published in Nature (London) (01-01-2019)“…For more than 50 years, the methylation of mammalian actin at histidine 73 has been known to occur 1 . Despite the pervasiveness of His73 methylation, which we…”
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2
Enhanced safety and efficacy of protease-regulated CAR-T cell receptors
Published in Cell (12-05-2022)“…Regulatable CAR platforms could circumvent toxicities associated with CAR-T therapy, but existing systems have shortcomings including leakiness and attenuated…”
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Ultrasound/microbubble-mediated targeted delivery of anticancer microRNA-loaded nanoparticles to deep tissues in pigs
Published in Journal of controlled release (10-09-2019)“…In this study, we designed and validated a platform for ultrasound and microbubble-mediated delivery of FDA-approved pegylated poly lactic-co-glycolic acid…”
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4
A protease-activated, near-infrared fluorescent probe for early endoscopic detection of premalignant gastrointestinal lesions
Published in Proceedings of the National Academy of Sciences - PNAS (05-01-2021)“…Fluorescence imaging is currently being actively developed for surgical guidance; however, it remains underutilized for diagnostic and endoscopic surveillance…”
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Embryonic Chicken (Gallus gallus domesticus) as a Model of Cardiac Biology and Development
Published in Comparative medicine (01-05-2019)“…Cardiovascular disease remains one of the top contributors to morbidity and mortality in the United States. Increasing evidence suggests that many processes,…”
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Notable surgical trials in gynecologic oncology: a 10-year overview
Published in International journal of gynecological cancer (05-08-2024)“…In the last decade, we have witnessed important advances in novel therapeutics in the management of gynecologic cancers. These studies have built on the…”
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7
Design of a mucin-selective protease for targeted degradation of cancer-associated mucins
Published in Nature biotechnology (01-04-2024)“…Targeted protein degradation is an emerging strategy for the elimination of classically undruggable proteins. Here, to expand the landscape of targetable…”
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Investigating circulating tumor cells and distant metastases in patient-derived orthotopic xenograft models of triple-negative breast cancer
Published in Breast cancer research : BCR (28-08-2019)“…Circulating tumor cells (CTCs) represent a temporal "snapshot" of a patient's cancer and changes that occur during disease evolution. There is an extensive…”
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In‐Depth Analysis of the Complex Interactions Induced by Nanolayered Additives in PHBV Nanocomposites
Published in Macromolecular materials and engineering (01-07-2024)“…New nanocomposites based on biopolymer poly(3‐hydroxybutyrate‐ co ‐3‐hydroxyvalerate) (PHBV) are processed via extrusion, using low content of calcined…”
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10
Electrodes Based on Carbon Aerogels Partially Graphitized by Doping with Transition Metals for Oxygen Reduction Reaction
Published in Nanomaterials (Basel, Switzerland) (23-04-2018)“…A series of carbon aerogels doped with iron, cobalt and nickel have been prepared. Metal nanoparticles very well dispersed into the carbon matrix catalyze the…”
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Receptor subtype discrimination using extensive shape complementary designed interfaces
Published in Nature structural & molecular biology (01-06-2019)“…To discriminate between closely related members of a protein family that differ at a limited number of spatially distant positions is a challenge for drug…”
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Effect of Washing Treatment on the Textural Properties and Bioactivity of Silica/Chitosan/TCP Xerogels for Bone Regeneration
Published in International journal of molecular sciences (01-08-2021)“…Silica/biopolymer hydrogel-based materials constitute very attractive platforms for various emerging biomedical applications, particularly for bone repair. The…”
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13
Molecular Imaging of Infective Endocarditis With 6′′-[18F]Fluoromaltotriose Positron Emission Tomography–Computed Tomography
Published in Circulation (New York, N.Y.) (26-05-2020)Get full text
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14
Ribbon‐like microfiber of vulcanized and non‐vulcanized natural rubber obtained by the solution blow spinning
Published in Polymers for advanced technologies (01-02-2024)“…Natural rubber (NR) microfibers were obtained from NR/chloroform solutions with or without vulcanization agents, by a solution blow spinning (SBS) technique…”
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Block Copolymer-Based Membranes for Vanadium Redox Flow Batteries: Synthesis, Characterization, and Performance
Published in ACS applied polymer materials (09-08-2024)“…Nonfluorinated polymers have been widely proposed to replace Nafion as raw materials for redox flow battery ion-exchange membranes. Hereby, block copolymers…”
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Ablation of Adar1 in myeloid cells imprints a global antiviral state in the lung and heightens early immunity against SARS-CoV-2
Published in Cell reports (Cambridge) (31-01-2023)“…Under normal homeostatic conditions, self-double-stranded RNA (self-dsRNA) is modified by adenosine deaminase acting on RNA 1 (ADAR1) to prevent the induction…”
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Effect of temperature on the rheological behavior of a new aqueous liquid crystal bio-lubricant
Published in Journal of molecular liquids (01-03-2020)“…The rheological behavior of bis[(2-hydroxyethyl)ammonium] palmitate (DPA) fatty acid-derived ionic liquid crystal (ILC) and its dispersions in water has been…”
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Extruded PLA Nanocomposites Modified by Graphene Oxide and Ionic Liquid
Published in Polymers (22-02-2021)“…Polylactic acid (PLA)-based nanocomposites were prepared by twin-screw extrusion. Graphene oxide (GO) and an ionic liquid (IL) were used as additives…”
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Management of Morbidity and Mortality in a New Zealand White Rabbit Model of Steroid-Induced Osteonecrosis of the Femoral Head
Published in Comparative medicine (01-02-2021)“…Steroid-induced osteonecrosis of the femoral head (SONFH) is a condition documented in humans and animals exposed to chronic steroid administration. The rabbit…”
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Primary ovarian endometrioid stromal sarcoma presenting with reno-ureteral colic
Published in BMC women's health (03-12-2022)“…Endometrioid Stromal Sarcomas are an infrequent group of mesenchymal tumors that we must take into account in the differential diagnosis despite representing…”
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