Search Results - "Vila Petroff, Martín"

Chasing cardiac physiology and pathology down the CaMKII cascade by Mattiazzi, Alicia, Bassani, Rosana A, Escobar, Ariel L, Palomeque, Julieta, Valverde, Carlos A, Vila Petroff, Martín, Bers, Donald M

“…Calcium dynamics is central in cardiac physiology, as the key event leading to the excitation-contraction coupling (ECC) and relaxation processes. The primary…”
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Discordant Ca2+ release in cardiac myocytes: characterization and susceptibility to pharmacological RyR2 modulation by Sommese, Leandro M., Racioppi, María Florencia, Shen, Xin, Orlowski, Alejandro, Valverde, Carlos A., Louch, William E., Vila Petroff, Martín, Gonano, Luis A.

“…Systolic Ca 2+ transients are shaped by the concerted summation of Ca 2+ sparks across cardiomyocytes. At high pacing rates, alterations of…”
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Metformin Reduces Potassium Currents and Prolongs Repolarization in Non-Diabetic Heart by Malagueta-Vieira, Layse, Fernández-Ruocco, Julieta, Hortigón-Vinagre, María P, Zamora, Víctor, Zayas-Arrabal, Julián, Echeazarra, Leyre, Smith, Godfrey L, Vila Petroff, Martín, Medei, Emiliano, Casis, Óscar, Gallego, Mónica

“…Metformin is the first choice drug for the treatment of type 2 diabetes due to positive results in reducing hyperglycaemia and insulin resistance. However,…”
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Nitric oxide and CaMKII: Critical steps in the cardiac contractile response To IGF-1 and swim training by Burgos, Juan I., Yeves, Alejandra M., Barrena, Jorge P., Portiansky, Enrique L., Vila-Petroff, Martín G., Ennis, Irene L.

“…Cardiac adaptation to endurance training includes improved contractility by a non-yet clarified mechanism. Since IGF-1 is the main mediator of the…”
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Cellular Mechanisms Underlying the Low Cardiotoxicity of Istaroxime by Racioppi, María Florencia, Burgos, Juan Ignacio, Morell, Malena, Gonano, Luis Alberto, Vila Petroff, Martín

“…Background Istaroxime is an inhibitor of Na + /K + ATPase with proven efficacy to increase cardiac contractility and to accelerate relaxation attributable to a…”
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Aldosterone stimulates the cardiac sodium/bicarbonate cotransporter via activation of the g protein-coupled receptor gpr30 by De Giusti, Verónica C, Orlowski, Alejandro, Ciancio, María C, Espejo, María S, Gonano, Luis A, Caldiz, Claudia I, Vila Petroff, Martín G, Villa-Abrille, María C, Aiello, Ernesto A

“…Abstract Some cardiac non-genomic effects of aldosterone (Ald) are reported to be mediated through activation of the classic mineralocorticoid receptor (MR)…”
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The reduced myofilament responsiveness to calcium contributes to the negative force-frequency relationship in rat cardiomyocytes: role of reactive oxygen species and p-38 map kinase by Espejo, María Sofía, Aiello, Ignacio, Sepúlveda, Marisa, Vila Petroff, Martín G., Aiello, Ernesto A., De Giusti, Verónica C.

“…The force-frequency relationship (FFR) is an important intrinsic regulatory mechanism of cardiac contractility. However, a decrease (negative FFR) or no effect…”
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Glucagon-Like Peptide-1 Increases cAMP but Fails to Augment Contraction in Adult Rat Cardiac Myocytes by Vila Petroff, Martín G, Egan, Josephine M, Wang, Xiaolin, Sollott, Steven J

“…The gut hormone, glucagon-like peptide-1 (GLP-1), which is secreted in nanomolar amounts in response to nutrients in the intestinal lumen, exerts cAMP/protein…”
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Subcellular Mechanisms Underlying Digitalis-Induced Arrhythmias: Role of Calcium/Calmodulin-Dependent Kinase II (CaMKII) in the Transition from an Inotropic to an Arrhythmogenic Effect by Gonano, Luis Alberto, Petroff, Martín Vila

“…Cardiotonic glycosides or digitalis are positive inotropes used in clinical practice for the treatment of heart failure, which also exist as endogenous ligands…”
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Angiotensin II-induced negative inotropy in rat ventricular myocytes: role of reactive oxygen species and p38 MAPK by Palomeque, Julieta, Sapia, Luciana, Hajjar, Roger J, Mattiazzi, Alicia, Vila Petroff, Martín

“…The octapeptide angiotensin II (ANG II) can modulate cardiac contractility and is increased in heart failure, where contractile function is impaired. In rat…”
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Calcium/Calmodulin Protein Kinase II-Dependent Ryanodine Receptor Phosphorylation Mediates Cardiac Contractile Dysfunction Associated With Sepsis by Sepúlveda, Marisa, Gonano, Luis A., Viotti, Manuel, Morell, Malena, Blanco, Paula, López Alarcón, Micaela, Peroba Ramos, Isalira, Bastos Carvalho, Adriana, Medei, Emiliano, Vila Petroff, Martín

“…OBJECTIVES:Sepsis is associated with cardiac contractile dysfunction attributed to alterations in Ca handling. We examined the subcellular mechanisms involved…”
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Toll-Like Receptor 4 and NLRP3 Caspase 1- Interleukin-1β-Axis are Not Involved in Colon Ascendens Stent Peritonitis-Associated Heart Disease by Alarcón, Maria Micaela Lopez, Ruocco, Julieta Fernández, Ferreira, Fabiano, Paula-Neto, Heitor A, Sepúlveda, Marisa, Vila Petroff, Martín, Carvalho, Adriana Bastos, Ramos, Isalira Peroba, Branda, Hugo Justino, Paiva, Claudia N, Medei, Emiliano

“…ABSTRACTHemodynamic collapse and myocardial dysfunction are among the major causes of death in severe sepsis. The purpose of this study was to assess the role…”
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Subcellular mechanisms of the positive inotropic effect of angiotensin II in cat myocardium by Petroff, Martín G. Vila, Aiello, Ernesto A., Palomeque, Julieta, Salas, Margarita A., Mattiazzi, Alicia

“…Cat ventricular myocytes loaded with [Ca 2+ ] i - and pH i -sensitive probes were used to examine the subcellular mechanism(s) of the Ang II-induced positive…”
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Role of CaMKII and ROS in rapid pacing-induced apoptosis by Sepúlveda, Marisa, Gonano, Luis A, Back, Tom G, Chen, S.R. Wayne, Vila Petroff, Martin

“…Abstract Tachycardia promotes cell death and cardiac remodeling, leading to congestive heart failure. However, the underlying mechanism of tachycardia- or…”
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Non-β-Blocking Carvedilol Analog, VK-II-86, Prevents Ouabain-Induced Cardiotoxicity by Gonano, Luis A., Sepúlveda, Marisa, Morell, Malena, Toteff, Tamara, Racioppi, María Florencia, Lascano, Elena, Negroni, Jorge, Ruocco, María Julieta Fernández, Medei, Emiliano, Neiman, Gabriel, Miriuka, Santiago G., Back, Thomas G., Chen, S. R. Wayne, Mattiazzi, Alicia, Petroff, Martin Vila

“…Background: It has been shown that carvedilol and its non β-blocking analog, VK-II-86, inhibit spontaneous Ca2+ release from the sarcoplasmic reticulum (SR)…”
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Endogenous nitric oxide mechanisms mediate the stretch dependence of Ca2+ release in cardiomyocytes by Petroff, M G, Kim, S H, Pepe, S, Dessy, C, Marbán, E, Balligand, J L, Sollott, S J

“…Stretching of cardiac muscle modulates contraction through the enhancement of the Ca2+ transient, but how this occurs is still not known. We found that…”
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Calcium-Calmodulin Kinase II Mediates Digitalis-Induced Arrhythmias by Gonano, Luis A, Sepúlveda, Marisa, Rico, Yanina, Kaetzel, Marcia, Valverde, Carlos A, Dedman, John, Mattiazzi, Alicia, Vila Petroff, Martin

“…BACKGROUND—Digitalis-induced Na accumulation results in an increase in Cai via the Na/Ca exchanger, leading to enhanced sarcoplasmic reticulum (SR) Ca load,…”
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The electrogenic Na+/HCO3− cotransport modulates resting membrane potential and action potential duration in cat ventricular myocytes by Villa‐Abrille, María C., Petroff, Martín G. Vila, Aiello, Ernesto A.

“…Perforated whole‐cell configuration of patch clamp was used to determine the contribution of the electrogenic Na+/HCO3− cotransport (NBC) on the shape of the…”
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Evidence for an electrogenic Na+‐HCO3− symport in rat cardiac myocytes by Aiello, Ernesto A., Petroff, Martín G. Vila, Mattiazzi, Alicia R., Cingolani, Horacio E.

“…1 The perforated whole‐cell configuration of patch clamp and the pH fluorescent indicator SNARF were used to determine the electrogenicity of the Na+‐HCO3−…”
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Is Bauman's "liquid modernity" influencing the way we are doing science? by Mattiazzi, Alicia, Vila-Petroff, Martín

“…This commentary analyzes the possible effects of lightness-a typical attribute of modern (liquid) society, according to Bauman-on the way we are doing science…”
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