Search Results - "Vila, Miquel"

Neuromelanin, aging, and neuronal vulnerability in Parkinson's disease by Vila, Miquel

“…Neuromelanin, a dark brown intracellular pigment, has long been associated with Parkinson's disease (PD). In PD, neuromelanin‐containing neurons preferentially…”
Get full text

Mitochondrial Quality Control in Neurodegenerative Diseases: Focus on Parkinson's Disease and Huntington's Disease by Franco-Iborra, Sandra, Vila, Miquel, Perier, Celine

“…In recent years, several important advances have been made in our understanding of the pathways that lead to cell dysfunction and death in Parkinson's disease…”
Get full text

Brain tyrosinase overexpression implicates age-dependent neuromelanin production in Parkinson’s disease pathogenesis by Carballo-Carbajal, Iria, Laguna, Ariadna, Romero-Giménez, Jordi, Cuadros, Thais, Bové, Jordi, Martinez-Vicente, Marta, Parent, Annabelle, Gonzalez-Sepulveda, Marta, Peñuelas, Núria, Torra, Albert, Rodríguez-Galván, Beatriz, Ballabio, Andrea, Hasegawa, Takafumi, Bortolozzi, Analía, Gelpi, Ellen, Vila, Miquel

“…In Parkinson’s disease (PD) there is a selective degeneration of neuromelanin-containing neurons, especially substantia nigra dopaminergic neurons. In humans,…”
Get full text

Chemical tagging and customizing of cellular chromatin states using ultrafast trans-splicing inteins by David, Yael, Vila-Perelló, Miquel, Verma, Shivam, Muir, Tom W.

“…Post-translational modification of the histone proteins in chromatin plays a central role in the epigenetic control of DNA-templated processes in eukaryotic…”
Get full text

Pathogenic lysosomal depletion in Parkinson's disease by Dehay, Benjamin, Bové, Jordi, Rodríguez-Muela, Natalia, Perier, Celine, Recasens, Ariadna, Boya, Patricia, Vila, Miquel

“…Mounting evidence suggests a role for autophagy dysregulation in Parkinson's disease (PD). The bulk degradation of cytoplasmic proteins (including α-synuclein)…”
Get full text

LRRK2 in Parkinson disease: challenges of clinical trials by Tolosa, Eduardo, Vila, Miquel, Klein, Christine, Rascol, Olivier

“…One of the most common monogenic forms of Parkinson disease (PD) is caused by mutations in the LRRK2 gene that encodes leucine-rich repeat kinase 2 (LRRK2)…”
Get full text

Microplate tectonics and environmental factors as distribution drivers in Western Mediterranean freshwater planarians by Leria, Laia, Riutort, Marta, Romero, Rafael, Ferrer, Xavier, Vila‐Farré, Miquel

“…Aim Species biogeography mainly focuses on palaeogeographical events, while environmental factors are generally overlooked despite their importance in species…”
Get full text

Defective mitochondrial protein import contributes to complex I-induced mitochondrial dysfunction and neurodegeneration in Parkinson’s disease by Franco-Iborra, Sandra, Cuadros, Thais, Parent, Annabelle, Romero-Gimenez, Jordi, Vila, Miquel, Perier, Celine

“…Mitochondria are the prime energy source in most eukaryotic cells, but these highly dynamic organelles are also involved in a multitude of cellular events…”
Get full text

Targeting α-synuclein for treatment of Parkinson's disease: mechanistic and therapeutic considerations by Dehay, Benjamin, PhD, Bourdenx, Mathieu, MS, Gorry, Philippe, MD, Przedborski, Serge, Prof, Vila, Miquel, MD, Hunot, Stéphane, PhD, Singleton, Andrew, PhD, Olanow, C Warren, Prof, Merchant, Kalpana M, PhD, Bezard, Erwan, Prof, Petsko, Gregory A, Prof, Meissner, Wassilios G, Prof

“…Summary Progressive neuronal cell loss in a small subset of brainstem and mesencephalic nuclei and widespread aggregation of the α-synuclein protein in the…”
Get full text

Bidirectional gut-to-brain and brain-to-gut propagation of synucleinopathy in non-human primates by Arotcarena, Marie-Laure, Dovero, Sandra, Prigent, Alice, Bourdenx, Mathieu, Camus, Sandrine, Porras, Gregory, Thiolat, Marie-Laure, Tasselli, Maddalena, Aubert, Philippe, Kruse, Niels, Mollenhauer, Brit, Trigo Damas, Ines, Estrada, Cristina, Garcia-Carrillo, Nuria, Vaikath, Nishant N, El-Agnaf, Omar M A, Herrero, Maria Trinidad, Vila, Miquel, Obeso, Jose A, Derkinderen, Pascal, Dehay, Benjamin, Bezard, Erwan

“…In Parkinson's disease, synucleinopathy is hypothesized to spread from the enteric nervous system, via the vagus nerve, to the CNS. Here, we compare, in baboon…”
Get full text

The spatiotemporal changes in dopamine, neuromelanin and iron characterizing Parkinson's disease by Biondetti, Emma, Santin, Mathieu D, Valabrègue, Romain, Mangone, Graziella, Gaurav, Rahul, Pyatigorskaya, Nadya, Hutchison, Matthew, Yahia-Cherif, Lydia, Villain, Nicolas, Habert, Marie-Odile, Arnulf, Isabelle, Leu-Semenescu, Smaranda, Dodet, Pauline, Vila, Miquel, Corvol, Jean-Christophe, Vidailhet, Marie, Lehéricy, Stéphane

“…In Parkinson's disease, there is a progressive reduction in striatal dopaminergic function, and loss of neuromelanin-containing dopaminergic neurons and…”
Get full text

Alpha-synuclein propagation: New insights from animal models by Dehay, Benjamin, Vila, Miquel, Bezard, Erwan, Brundin, Patrik, Kordower, Jeffrey H.

“…Aggregation of alpha-synuclein is implicated in several neurodegenerative diseases collectively termed synucleinopathies. Emerging evidence strongly implicates…”
Get full text

Lysosomal impairment in Parkinson's disease by Dehay, Benjamin, Martinez-Vicente, Marta, Caldwell, Guy A., Caldwell, Kim A., Yue, Zhenyue, Cookson, Mark R., Klein, Christine, Vila, Miquel, Bezard, Erwan

“…ABSTRACT Impairment of autophagy‐lysosomal pathways (ALPs) is increasingly regarded as a major pathogenic event in neurodegenerative diseases, including…”
Get full text

Chitinase 3-like 1 is neurotoxic in primary cultured neurons by Matute-Blanch, Clara, Calvo-Barreiro, Laura, Carballo-Carbajal, Iria, Gonzalo, Ricardo, Sanchez, Alex, Vila, Miquel, Montalban, Xavier, Comabella, Manuel

“…Chitinase 3-like 1 (CHI3L1) is known to play a role as prognostic biomarker in the early stages of multiple sclerosis (MS), and patients with high…”
Get full text

Detection of cell–cell interactions via photocatalytic cell tagging by Oslund, Rob C., Reyes-Robles, Tamara, White, Cory H., Tomlinson, Jake H., Crotty, Kelly A., Bowman, Edward P., Chang, Dan, Peterson, Vanessa M., Li, Lixia, Frutos, Silvia, Vila-Perelló, Miquel, Vlerick, David, Cromie, Karen, Perlman, David H., Ingale, Sampat, Hara, Samantha D. O’, Roberts, Lee R., Piizzi, Grazia, Hett, Erik C., Hazuda, Daria J., Fadeyi, Olugbeminiyi O.

“…The growing appreciation of immune cell–cell interactions within disease environments has led to extensive efforts to develop immunotherapies. However,…”
Get full text

Disease‐specific phenotypes in dopamine neurons from human iPS‐based models of genetic and sporadic Parkinson's disease by Sánchez‐Danés, Adriana, Richaud‐Patin, Yvonne, Carballo‐Carbajal, Iria, Jiménez‐Delgado, Senda, Caig, Carles, Mora, Sergio, Di Guglielmo, Claudia, Ezquerra, Mario, Patel, Bindiben, Giralt, Albert, Canals, Josep M., Memo, Maurizio, Alberch, Jordi, López‐Barneo, José, Vila, Miquel, Cuervo, Ana Maria, Tolosa, Eduard, Consiglio, Antonella, Raya, Angel

“…Induced pluripotent stem cells (iPSC) offer an unprecedented opportunity to model human disease in relevant cell types, but it is unclear whether they could…”
Get full text

Sediment characterization in deltas using electrical resistivity tomography: The Ebro delta case by Bellmunt, Fabian, Gabàs, Anna, Macau, Albert, Benjumea, Beatriz, Vilà, Miquel, Figueras, Sara

“…Surface electrical resistivity tomography is a non-invasive and highly competitive technique that can be used to effectively characterize subsurface sediments…”
Get full text

Loss of P-type ATPase ATP13A2/PARK9 function induces general lysosomal deficiency and leads to Parkinson disease neurodegeneration by Dehay, Benjamin, Ramirez, Alfredo, Martinez-Vicente, Marta, Perier, Celine, Canron, Marie-Hélène, Doudnikoff, Evelyne, Vital, Anne, Vila, Miquel, Klein, Christine, Bezard, Erwan

“…Parkinson disease (PD) is a progressive neurodegenerative disorder pathologically characterized by the loss of dopaminergic neurons from the substantia nigra…”
Get full text

Outstanding intraindividual genetic diversity in fissiparous planarians (Dugesia, Platyhelminthes) with facultative sex by Leria, Laia, Vila-Farré, Miquel, Solà, Eduard, Riutort, Marta

“…Predicted genetic consequences of asexuality include high intraindividual genetic diversity (i.e., the Meselson effect) and accumulation of deleterious…”
Get full text

Overexpression of TFEB Drives a Pleiotropic Neurotrophic Effect and Prevents Parkinson’s Disease-Related Neurodegeneration by Torra, Albert, Parent, Annabelle, Cuadros, Thais, Rodríguez-Galván, Beatriz, Ruiz-Bronchal, Esther, Ballabio, Andrea, Bortolozzi, Analía, Vila, Miquel, Bové, Jordi

“…The possible implication of transcription factor EB (TFEB) as a therapeutic target in Parkinson’s disease has gained momentum since it was discovered that TFEB…”
Get full text