Search Results - "Vila, Cristina"
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Increased expression of the ATP‐gated P2X7 receptor reduces responsiveness to anti‐convulsants during status epilepticus in mice
Published in British journal of pharmacology (01-06-2022)“…Background and Purpose Refractory status epilepticus is a clinical emergency associated with high mortality and morbidity. Increasing evidence suggests…”
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2
P2X7 receptor activation impairs antitumour activity of natural killer cells
Published in British journal of pharmacology (01-01-2023)“…Background and purpose A high number of intratumoural infiltrating natural killer (NK) cells is associated with better survival in several types of cancer,…”
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3
Evolutionary analyses of the gasdermin family suggest conserved roles in infection response despite loss of pore-forming functionality
Published in BMC biology (07-01-2022)“…Gasdermins are ancient (>500million-years-ago) proteins, constituting a family of pore-forming proteins that allow the release of intracellular content…”
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4
Purinergic receptors and the inflammatory response mediated by lipids
Published in Current opinion in pharmacology (01-08-2019)“…•Inflammation is regulated by eicosanoids and extracellular nucleotides.•Purinergic P2X7 and P2X4 receptor activation enhance the production of…”
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Endoplasmic Reticulum Stress-Induced Upregulation of STARD1 Promotes Acetaminophen-Induced Acute Liver Failure
Published in Gastroenterology (New York, N.Y. 1943) (01-08-2019)“…Acetaminophen (APAP) overdose is a major cause of acute liver failure (ALF). Mitochondrial SH3BP5 (also called SAB) and phosphorylation of c-Jun N-terminal…”
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6
Sensing low intracellular potassium by NLRP3 results in a stable open structure that promotes inflammasome activation
Published in Science advances (17-09-2021)“…The NLRP3 inflammasome is activated by a wide range of stimuli and drives diverse inflammatory diseases. The decrease of intracellular K concentration is a…”
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7
Numerical Modeling of Injection‐Induced Earthquakes Using Laboratory‐Derived Friction Laws
Published in Water resources research (01-12-2018)“…Modeling injection‐induced earthquakes requires coupling porous media flow, rock mechanics, and fault friction. Highly nonlinear laboratory‐derived…”
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8
Myristic acid potentiates palmitic acid-induced lipotoxicity and steatohepatitis associated with lipodystrophy by sustaning de novo ceramide synthesis
Published in Oncotarget (08-12-2015)“…Palmitic acid (PA) induces hepatocyte apoptosis and fuels de novo ceramide synthesis in the endoplasmic reticulum (ER). Myristic acid (MA), a free fatty acid…”
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CD14 release induced by P2X7 receptor restricts inflammation and increases survival during sepsis
Published in eLife (02-11-2020)“…P2X7 receptor activation induces the release of different cellular proteins, such as CD14, a glycosylphosphatidylinositol (GPI)-anchored protein to the plasma…”
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10
Dietary and genetic disruption of hepatic methionine metabolism induce acid sphingomyelinase to promote steatohepatitis
Published in Redox biology (01-02-2023)“…Alcoholic (ASH) and nonalcoholic. (NASH).steatohepatitis are advanced.stages.of.fatty.liver.disease.Methionine adenosyltransferase 1A (MAT1A) plays a key role…”
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Ferritin, Serum Iron and Hemoglobin as Acute Phase Reactants in Laparoscopic and Open Surgery of Cholecystectomy: An Observational Prospective Study
Published in Pathophysiology (Amsterdam) (11-10-2022)“…Cytokines are expressed by various cells after several stimuli such as surgical tissue damage, producing a systemic inflammatory response (SIR). C-reactive…”
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12
Lysosomal Cholesterol Accumulation Sensitizes To Acetaminophen Hepatotoxicity by Impairing Mitophagy
Published in Scientific reports (11-12-2015)“…The role of lysosomes in acetaminophen (APAP) hepatotoxicity is poorly understood. Here, we investigated the impact of genetic and drug-induced lysosomal…”
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13
Is fine-needle aspiration a reliable tool in the diagnosis of malignant salivary gland tumors?
Published in Journal of cranio-maxillo-facial surgery (01-07-2017)“…The purpose of the present study was to establish the reliability of fine needle aspiration (FNA) in the diagnosis of malignant salivary gland tumors in our…”
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14
Human embryonic mesenchymal lung-conditioned medium promotes differentiation to myofibroblast and loss of stemness phenotype in lung adenocarcinoma cell lines
Published in Journal of experimental & clinical cancer research (26-01-2022)“…When genes responsible for normal embryonic development are abnormally expressed in adults, it can lead to tumor development. This can suggest that the same…”
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15
A Holistic Approach in Re-Mining Old Tailings Deposits for the Supply of Critical-Metals: A Portuguese Case Study
Published in Minerals (Basel) (01-10-2019)“…Demand growth for metallic minerals has been faced with the need for new techniques and improving technologies for all mining life-cycle operations. Nowadays,…”
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P2X7 receptor induces mitochondrial failure in monocytes and compromises NLRP3 inflammasome activation during sepsis
Published in Nature communications (20-06-2019)“…Sepsis is characterized by a systemic inflammatory response followed by immunosuppression of the host. Metabolic defects and mitochondrial failure are common…”
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The Legacy of Potential Environmental Soil Contamination in an Antimony Mining Heritage Area
Published in Minerals (Basel) (01-02-2023)“…In the Valongo Belt, with an extension of about 90 km, located very close to Porto, northern Portugal, dozens of ore deposits of various metallic minerals and…”
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Effectiveness of the Modification of Sewers to Reduce the Reproduction of Culex pipiens and Aedes albopictus in Barcelona, Spain
Published in Pathogens (Basel) (31-03-2022)“…Mosquitoes breeding in urban sewage infrastructure are both a source of nuisance to the local population and a public health risk, given that biting mosquitoes…”
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Is there a learning effect on 1-min sit-to-stand test in post-COVID-19 patients?
Published in ERJ open research (01-07-2022)“…https://bit.ly/3y3ycAP…”
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Plant species richness and abundance in residential yards across a tropical watershed: implications for urban sustainability
Published in Ecology and society (01-01-2014)“…Green spaces within residential areas provide important contributions to the sustainability of urban systems. Therefore, studying the characteristics of these…”
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