Search Results - "Vijay G. Sankaran"

Scalable, multimodal profiling of chromatin accessibility, gene expression and protein levels in single cells by Mimitou, Eleni P., Lareau, Caleb A., Chen, Kelvin Y., Zorzetto-Fernandes, Andre L., Hao, Yuhan, Takeshima, Yusuke, Luo, Wendy, Huang, Tse-Shun, Yeung, Bertrand Z., Papalexi, Efthymia, Thakore, Pratiksha I., Kibayashi, Tatsuya, Wing, James Badger, Hata, Mayu, Satija, Rahul, Nazor, Kristopher L., Sakaguchi, Shimon, Ludwig, Leif S., Sankaran, Vijay G., Regev, Aviv, Smibert, Peter

“…Recent technological advances have enabled massively parallel chromatin profiling with scATAC-seq (single-cell assay for transposase accessible chromatin by…”
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Advances in understanding erythropoiesis: evolving perspectives by Nandakumar, Satish K., Ulirsch, Jacob C., Sankaran, Vijay G.

“…Summary Red blood cells (RBCs) are generated from haematopoietic stem and progenitor cells (HSPCs) through the step‐wise process of differentiation known as…”
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Lineage Tracing in Humans Enabled by Mitochondrial Mutations and Single-Cell Genomics by Ludwig, Leif S., Lareau, Caleb A., Ulirsch, Jacob C., Christian, Elena, Muus, Christoph, Li, Lauren H., Pelka, Karin, Ge, Will, Oren, Yaara, Brack, Alison, Law, Travis, Rodman, Christopher, Chen, Jonathan H., Boland, Genevieve M., Hacohen, Nir, Rozenblatt-Rosen, Orit, Aryee, Martin J., Buenrostro, Jason D., Regev, Aviv, Sankaran, Vijay G.

“…Lineage tracing provides key insights into the fate of individual cells in complex organisms. Although effective genetic labeling approaches are available in…”
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Systematic Functional Dissection of Common Genetic Variation Affecting Red Blood Cell Traits by Ulirsch, Jacob C., Nandakumar, Satish K., Wang, Li, Giani, Felix C., Zhang, Xiaolan, Rogov, Peter, Melnikov, Alexandre, McDonel, Patrick, Do, Ron, Mikkelsen, Tarjei S., Sankaran, Vijay G.

“…Genome-wide association studies (GWAS) have successfully identified thousands of associations between common genetic variants and human disease phenotypes, but…”
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MECOM Deficiency: from Bone Marrow Failure to Impaired B-Cell Development by Voit, Richard A., Sankaran, Vijay G.

“…MECOM deficiency is a recently identified inborn error of immunity and inherited bone marrow failure syndrome caused by haploinsufficiency of the hematopoietic…”
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Hacking hematopoiesis - emerging tools for examining variant effects by Gundry, Michael, Sankaran, Vijay G

“…Hematopoiesis is a continuous process of blood and immune cell production. It is orchestrated by thousands of gene products that respond to extracellular…”
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Targeted therapeutic strategies for fetal hemoglobin induction by Sankaran, Vijay G

“…Increased levels of fetal hemoglobin (HbF) can ameliorate the severity of the β-hemoglobin disorders, sickle cell disease (SCD) and β-thalassemia, which are…”
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The Genetic Landscape of Diamond-Blackfan Anemia by Ulirsch, Jacob C., Verboon, Jeffrey M., Kazerounian, Shideh, Guo, Michael H., Yuan, Daniel, Ludwig, Leif S., Handsaker, Robert E., Abdulhay, Nour J., Fiorini, Claudia, Genovese, Giulio, Lim, Elaine T., Cheng, Aaron, Cummings, Beryl B., Chao, Katherine R., Beggs, Alan H., Genetti, Casie A., Sieff, Colin A., Newburger, Peter E., Niewiadomska, Edyta, Matysiak, Michal, Vlachos, Adrianna, Lipton, Jeffrey M., Atsidaftos, Eva, Glader, Bertil, Narla, Anupama, Gleizes, Pierre-Emmanuel, O’Donohue, Marie-Françoise, Montel-Lehry, Nathalie, Amor, David J., McCarroll, Steven A., O’Donnell-Luria, Anne H., Gupta, Namrata, Gabriel, Stacey B., MacArthur, Daniel G., Lander, Eric S., Lek, Monkol, Da Costa, Lydie, Nathan, David G., Korostelev, Andrei A., Do, Ron, Sankaran, Vijay G., Gazda, Hanna T.

“…Diamond-Blackfan anemia (DBA) is a rare bone marrow failure disorder that affects 7 out of 1,000,000 live births and has been associated with mutations in…”
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Pathogenic BCL11A variants provide insights into the mechanisms of human fetal hemoglobin silencing by Shen, Yong, Li, Rick, Teichert, Kristian, Montbleau, Kara E, Verboon, Jeffrey M, Voit, Richard A, Sankaran, Vijay G

“…Increased production of fetal hemoglobin (HbF) can ameliorate the severity of sickle cell disease and β-thalassemia. BCL11A has been identified as a key…”
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Interrogation of human hematopoiesis at single-cell and single-variant resolution by Ulirsch, Jacob C., Lareau, Caleb A., Bao, Erik L., Ludwig, Leif S., Guo, Michael H., Benner, Christian, Satpathy, Ansuman T., Kartha, Vinay K., Salem, Rany M., Hirschhorn, Joel N., Finucane, Hilary K., Aryee, Martin J., Buenrostro, Jason D., Sankaran, Vijay G.

“…Widespread linkage disequilibrium and incomplete annotation of cell-to-cell state variation represent substantial challenges to elucidating mechanisms of…”
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Transcriptional States and Chromatin Accessibility Underlying Human Erythropoiesis by Ludwig, Leif S, Lareau, Caleb A, Bao, Erik L, Nandakumar, Satish K, Muus, Christoph, Ulirsch, Jacob C, Chowdhary, Kaitavjeet, Buenrostro, Jason D, Mohandas, Narla, An, Xiuli, Aryee, Martin J, Regev, Aviv, Sankaran, Vijay G

“…Human erythropoiesis serves as a paradigm of physiologic cellular differentiation. This process is also of considerable interest for better understanding…”
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A genetic disorder reveals a hematopoietic stem cell regulatory network co-opted in leukemia by Voit, Richard A., Tao, Liming, Yu, Fulong, Cato, Liam D., Cohen, Blake, Fleming, Travis J., Antoszewski, Mateusz, Liao, Xiaotian, Fiorini, Claudia, Nandakumar, Satish K., Wahlster, Lara, Teichert, Kristian, Regev, Aviv, Sankaran, Vijay G.

“…The molecular regulation of human hematopoietic stem cell (HSC) maintenance is therapeutically important, but limitations in experimental systems and…”
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Topological control of cytokine receptor signaling induces differential effects in hematopoiesis by Mohan, Kritika, Ueda, George, Kim, Ah Ram, Jude, Kevin M, Fallas, Jorge A, Guo, Yu, Hafer, Maximillian, Miao, Yi, Saxton, Robert A, Piehler, Jacob, Sankaran, Vijay G, Baker, David, Garcia, K Christopher

“…Although tunable signaling by G protein-coupled receptors can be exploited through medicinal chemistry, a comparable pharmacological approach has been lacking…”
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Control of human hemoglobin switching by LIN28B-mediated regulation of BCL11A translation by Basak, Anindita, Munschauer, Mathias, Lareau, Caleb A., Montbleau, Kara E., Ulirsch, Jacob C., Hartigan, Christina R., Schenone, Monica, Lian, John, Wang, Yaomei, Huang, Yumin, Wu, Xianfang, Gehrke, Lee, Rice, Charles M., An, Xiuli, Christou, Helen A., Mohandas, Narla, Carr, Steven A., Chen, Jane-Jane, Orkin, Stuart H., Lander, Eric S., Sankaran, Vijay G.

“…Increased production of fetal hemoglobin (HbF) can ameliorate the severity of sickle cell disease and β-thalassemia 1 . BCL11A represses the genes encoding HbF…”
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The genetics of human hematopoiesis and its disruption in disease by Bao, Erik L, Cheng, Aaron N, Sankaran, Vijay G

“…Hematopoiesis, or the process of blood cell production, is a paradigm of multi‐lineage cellular differentiation that has been extensively studied, yet in many…”
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Super interactive promoters provide insight into cell type-specific regulatory networks in blood lineage cell types by Wen, Jia, Lagler, Taylor M, Sun, Quan, Yang, Yuchen, Chen, Jiawen, Harigaya, Yuriko, Sankaran, Vijay G, Hu, Ming, Reiner, Alexander P, Raffield, Laura M, Li, Yun

“…Existing studies of chromatin conformation have primarily focused on potential enhancers interacting with gene promoters. By contrast, the interactivity of…”
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Functional Selectivity in Cytokine Signaling Revealed Through a Pathogenic EPO Mutation by Kim, Ah Ram, Ulirsch, Jacob C., Wilmes, Stephan, Unal, Ekrem, Moraga, Ignacio, Karakukcu, Musa, Yuan, Daniel, Kazerounian, Shideh, Abdulhay, Nour J., King, David S., Gupta, Namrata, Gabriel, Stacey B., Lander, Eric S., Patiroglu, Turkan, Ozcan, Alper, Ozdemir, Mehmet Akif, Garcia, K. Christopher, Piehler, Jacob, Gazda, Hanna T., Klein, Daryl E., Sankaran, Vijay G.

“…Cytokines are classically thought to stimulate downstream signaling pathways through monotonic activation of receptors. We describe a severe anemia resulting…”
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Transcriptional divergence and conservation of human and mouse erythropoiesis by Pishesha, Novalia, Thiru, Prathapan, Shi, Jiahai, Eng, Jennifer C., Sankaran, Vijay G., Lodish, Harvey F.

“…Mouse models have been used extensively for decades and have been instrumental in improving our understanding of mammalian erythropoiesis. Nonetheless, there…”
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DNA polymorphisms at the BCL11A, HBS1L-MYB, and β-globin loci associate with fetal hemoglobin levels and pain crises in sickle cell disease by Lettre, Guillaume, Sankaran, Vijay G, Bezerra, Marcos André C, Araújo, Aderson S, Uda, Manuela, Sanna, Serena, Cao, Antonio, Schlessinger, David, Costa, Fernando F, Hirschhorn, Joel N, Orkin, Stuart H

“…Sickle cell disease (SCD) is a debilitating monogenic blood disorder with a highly variable phenotype characterized by severe pain crises, acute clinical…”
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Clonal hematopoiesis in sickle cell disease by Liggett, L Alexander, Cato, Liam D, Weinstock, Joshua S, Zhang, Yingze, Nouraie, S Mehdi, Gladwin, Mark T, Garrett, Melanie E, Ashley-Koch, Allison, Telen, Marilyn J, Custer, Brian, Kelly, Shannon, Dinardo, Carla L, Sabino, Ester C, Loureiro, Paula, Carneiro-Proietti, Anna B, Maximo, Cláudia, Reiner, Alexander P, Abecasis, Gonçalo R, Williams, David A, Natarajan, Pradeep, Bick, Alexander G, Sankaran, Vijay G

“…BACKGROUNDCurative gene therapies for sickle cell disease (SCD) are currently undergoing clinical evaluation. The occurrence of myeloid malignancies in these…”
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