Search Results - "Viiklepp, Piret"
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Mortality in adults with multidrug-resistant tuberculosis and HIV by antiretroviral therapy and tuberculosis drug use: an individual patient data meta-analysis
Published in The Lancet (British edition) (08-08-2020)“…HIV-infection is associated with increased mortality during multidrug-resistant tuberculosis treatment, but the extent to which the use of antiretroviral…”
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Aminoglycosides and Capreomycin in the Treatment of Multidrug-resistant Tuberculosis: Individual Patient Data Meta-analysis of 12 030 Patients From 25 Countries, 2009–2016
Published in Clinical infectious diseases (06-12-2021)“…Abstract Background As new drugs are developed for multidrug-resistant tuberculosis (MDR-TB), the role of currently used drugs must be reevaluated. Methods We…”
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Estimating treatment importance in multidrug‐resistant tuberculosis using Targeted Learning: An observational individual patient data network meta‐analysis
Published in Biometrics (01-09-2020)“…Persons with multidrug‐resistant tuberculosis (MDR‐TB) have a disease resulting from a strain of tuberculosis (TB) that does not respond to at least isoniazid…”
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Spatiotemporal dynamics of drug‐resistant Mycobacterium tuberculosis: Contrasting trends and implications for tuberculosis control in EU high‐priority country
Published in Transboundary and emerging diseases (01-03-2021)“…Different and contrasting trends related to human migration and the implementation of health control programmes influence the spread of drug‐resistant…”
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Treatment Outcomes in Multidrug-Resistant Tuberculosis
Published in The New England journal of medicine (15-09-2016)“…Multidrug-resistant tuberculosis is a major global challenge. This report examines the definition of treatment success and its effect on determining cure. To…”
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Evaluating the performance of propensity score matching based approaches in individual patient data meta-analysis
Published in BMC medical research methodology (23-11-2021)“…Individual-patient data meta-analysis (IPD-MA) is an increasingly popular approach because of its analytical benefits. IPD-MA of observational studies must…”
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Modeling treatment effect modification in multidrug-resistant tuberculosis in an individual patientdata meta-analysis
Published in Statistical methods in medical research (01-04-2022)“…Effect modification occurs while the effect of the treatment is not homogeneous across the different strata of patient characteristics. When the effect of…”
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Surgery as an Adjunctive Treatment for Multidrug-Resistant Tuberculosis: An Individual Patient Data Metaanalysis
Published in Clinical infectious diseases (01-04-2016)“…Background. Medical treatment for multidrug-resistant (MDR)-tuberculosis is complex, toxic, and associated with poor outcomes. Surgical lung resection may be…”
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A successful introduction to a non-expert setting of the thin-layer agar Colour Test as an indirect phenotypic drug susceptibility test for Mycobacterium tuberculosis
Published in International journal of infectious diseases (01-03-2021)“…•Results from the thin-layer agar MDR/XDR-TB Colour Test are highly reproducible.•Implementation of the thin-layer agar Colour Test does not require skilled…”
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Sputum culture conversion as a prognostic marker for end-of-treatment outcome in patients with multidrug-resistant tuberculosis: a secondary analysis of data from two observational cohort studies
Published in The lancet respiratory medicine (01-03-2015)“…Summary Background Sputum culture conversion is often used as an early microbiological endpoint in phase 2 clinical trials of tuberculosis treatment on the…”
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Treatment outcomes of MDR-TB and HIV co-infection in Europe
Published in The European respiratory journal (01-06-2017)“…The ongoing HIV epidemic and the increasing number of patients with drug-resistant tuberculosis (TB) are seriously hampering global TB-control activities,…”
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Group 5 drugs for multidrug-resistant tuberculosis: individual patient data meta-analysis
Published in The European respiratory journal (01-01-2017)“…The role of so-called "group 5" second-line drugs as a part of antibiotic therapy for multidrug-resistant tuberculosis (MDR-TB) is widely debated. We performed…”
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Drug Susceptibility Patterns in MDR-TB Patients: Challenges for Future Regimen Design. A Cross-Sectional Study
Published in PloS one (11-11-2015)“…Globally, there is substantial concern regarding the challenges of treating complex drug resistance patterns in multidrug resistant tuberculosis cases…”
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Correction to: Reply to van Deun and Decroo
Published in Clinical infectious diseases (30-05-2022)Get full text
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Treatment correlates of successful outcomes in pulmonary multidrug-resistant tuberculosis: an individual patient data meta-analysis
Published in The Lancet (British edition) (08-09-2018)“…Treatment outcomes for multidrug-resistant tuberculosis remain poor. We aimed to estimate the association of treatment success and death with the use of…”
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Low Body Mass Index at Treatment Initiation and Rifampicin-Resistant Tuberculosis Treatment Outcomes: An Individual Participant Data Meta-Analysis
Published in Clinical infectious diseases (19-12-2022)“…Abstract Background The impact of low body mass index (BMI) at initiation of rifampicin-resistant tuberculosis (RR-TB) treatment on outcomes is uncertain. We…”
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Reply to van Deun and Decroo
Published in Clinical infectious diseases (15-06-2021)Get full text
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Emerging resistant clones of Mycobacterium tuberculosis in a spatiotemporal context
Published in Journal of antimicrobial chemotherapy (01-02-2018)“…We assessed the genetic structure of the Mycobacterium tuberculosis population in Estonia with a special focus on major epidemic/endemic clones and drug…”
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National lung cancer screening program feasibility study in Estonia
Published in Interdisciplinary cardiovascular and thoracic surgery (01-06-2023)“…Abstract OBJECTIVES The main aim of the lung cancer screening (LCS) feasibility study was to investigate the plausibility of and bottlenecks to systematic…”
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Tuberculosis elimination: theory and practice in Europe
Published in The European respiratory journal (01-05-2014)“…Although Europe identified the pathway to tuberculosis (TB) elimination in 1990, no information on programmes for country preparedness is available. A…”
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