Search Results - "Vihko, R."

Expression Cloning of a Novel Estrogenic Mouse 17β-Hydroxysteroid Dehydrogenase/ 17-Ketosteroid Reductase (m17HSD7), Previously Described as a Prolactin Receptor-Associated Protein (PRAP) in Rat by Nokelainen, Pasi, Peltoketo, Hellevi, Vihko, Reijo, Vihko, Pirkko

“…17β-Hydroxysteroid dehydrogenases/17-ketosteroid reductases (17HSDs) modulate the biological activity of certain estrogens and androgens by catalyzing…”
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Some endocrine characteristics of early menarche, a risk factor for breast cancer, are preserved into adulthood by Apter, D, Reinilä, M, Vihko, R

“…Early menarche is a risk factor for breast cancer. In a longitudinal manner, we have investigated the endocrine features of girls with early menarche. This…”
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Dietary estrogens act through estrogen receptor-mediated processes and show no antiestrogenicity in cultured breast cancer cells by Makela, S, Davis, V.L, Tally, W.C, Korkman, J, Salo, L, Vihko, R, Santti, R, Korach, K.S

“…Dietary estrogens are believed to exert their estrogenic or antiestrogenic (chemopreventive) action in estrogen responsive cells by interacting with the…”
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Complete amino acid sequence of human placental 17β-hydroxysteroid dehydrogenase deduced from cDNA by Peltoketo, H., Isomaa, V., Mäentausta, O., Vihko, R.

“…CDNA clones for 17β-hydroxysteroid dehydrogenase (17-HSD; EC 1.1.1.62) were isolated from a placental λgt11 expression library using polyclonal antibodies…”
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Endocrine determinants of fertility: serum androgen concentrations during follow-up of adolescents into the third decade of life by Apter, D, Vihko, R

“…We have completed a 13-yr longitudinal study of endocrine features in females originally aged 7-17 yr and report now factors related to fertility in these…”
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Differential estrogen substrate specificities for transiently expressed human placental 17 beta-hydroxysteroid dehydrogenase and an endogenous enzyme expressed in cultured COS-m6 cells by Poutanen, M, Miettinen, M, Vihko, R

“…The metabolism of estrogens catalyzed by human placental 17 beta-hydroxysteroid dehydrogenase (17HSD) transiently expressed in COS-m6 cells was studied, and…”
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Expression and regulation of 17 beta-hydroxysteroid dehydrogenase type 1 by Peltoketo, H, Isomaa, V, Poutanen, M, Vihko, R

“…The current data indicate that during a woman's reproductive years, 17 beta-hydroxysteroid dehydrogenase type 1 is the major 17 beta-hydroxysteroid…”
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Hormonal regulation of rat 17 beta-hydroxysteroid dehydrogenase type 1 in cultured rat granulosa cells: effects of recombinant follicle-stimulating hormone, estrogens, androgens, and epidermal growth factor by Ghersevich, S, Poutanen, M, Tapanainen, J, Vihko, R

“…Ovarian estradiol (E2) production is regulated by complex interaction of different hormones, such as gonadotropins, steroids, and growth factors. Despite the…”
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Characterization of Molecular and Catalytic Properties of Intact and Truncated Human 17β-Hydroxysteroid Dehydrogenase Type 2 Enzymes: Intracellular Localization of the Wild-Type Enzyme in the Endoplasmic Reticulum by Puranen, T. J., Kurkela, R. M., Lakkakorpi, J. T., Poutanen, M. H., Itäranta, P. V., Melis, J. P. J., Ghosh, D., Vihko, R. K., Vihko, P. T.

“…Abstract Human 17β-hydroxysteroid dehydrogenase (17HSD) type 2 is a widely distributed enzyme that primarily converts the highly active 17β-hydroxysteroids to…”
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Site-directed mutagenesis of the putative active site of human 17 beta-hydroxysteroid dehydrogenase type 1 by Puranen, T J, Poutanen, M H, Peltoketo, H E, Vihko, P T, Vihko, R K

“…Several amino acid residues (Cys54, Tyr155, His210, His213 and His221) at a putative catalytic site of human 17 beta-hydroxysteroid dehydrogenase type 1 were…”
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Expression of 17 beta-hydroxysteroid dehydrogenase in human granulosa cells: correlation with follicular size, cytochrome P450 aromatase activity and oestradiol production by Ghersevich, S A, Poutanen, M H, Martikainen, H K, Vihko, R K

“…The aim of this study was to examine the expression and regulation of type 1 17 beta-hydroxysteroid dehydrogenase (type 1 17-HSD) enzyme protein and mRNA, and…”
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Immunological analysis of 17 beta-hydroxysteroid dehydrogenase in benign and malignant human breast tissue by Poutanen, M, Isomaa, V, Lehto, V P, Vihko, R

“…The expression of 17 beta-hydroxysteroid dehydrogenase (17-HSD) enzyme protein was studied in benign and malignant human breast tissue using the time-resolved…”
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Human 17 beta-hydroxysteroid dehydrogenase type 1 and type 2 isoenzymes have opposite activities in cultured cells and characteristic cell- and tissue-specific expression by Miettinen, M M, Mustonen, M V, Poutanen, M H, Isomaa, V V, Vihko, R K

“…17 beta-Hydroxysteroid dehydrogenase (17HSD) isoenzymes catalyse the interconversion between highly active 17 beta-hydroxy- and low-activity 17-keto-steroids…”
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Mouse 17 beta-hydroxysteroid dehydrogenase type 2 mRNA is predominantly expressed in hepatocytes and in surface epithelial cells of the gastrointestinal and urinary tracts by Mustonen, MV, Poutanen, MH, Kellokumpu, S, de Launoit, Y, Isomaa, VV, Vihko, RK, Vihko, PT

“…17 beta-Hydroxysteroid dehydrogenase (17HSD) type 2 efficiently catalyzes the conversion of the high activity 17 beta-hydroxy forms of sex steroids into less…”
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Estrogen-specific 17 beta-hydroxysteroid oxidoreductase type 1 (E.C. 1.1.1.62) as a possible target for the action of phytoestrogens by Mäkelä, S, Poutanen, M, Lehtimäki, J, Kostian, M L, Santti, R, Vihko, R

“…Several plant estrogens, especially coumestrol and genistein, were found to reduce the conversion of [3H]estrone to [3H] 17 beta-estradiol catalyzed by…”
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Human 17β-hydroxysteroid dehydrogenase type 2 messenger ribonucleic acid expression and localization in term placenta and in endometrium during the menstrual cycle by MUSTONEN, M. V. J, ISOMAA, V. V, VASKIVUO, T, TAPANAINEN, J, POUTANEN, M. H, STENBÄCK, F, VIHKO, R. K, VIHKO, P. T

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Expression of 17 beta-hydroxysteroid dehydrogenase in the rat ovary during follicular development and luteinization induced with pregnant mare serum gonadotrophin and human chorionic gonadotrophin by Ghersevich, S A, Poutanen, M H, Rajaniemi, H J, Vihko, R K

“…Antibodies against human placental 17 beta-hydroxysteroid dehydrogenase (17-HSD) and 17-HSD cDNA were used to study the expression of the corresponding enzyme…”
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Endocrine characteristics of adolescent menstrual cycles: impact of early menarche by Vihko, R, Apter, D

“…An initial group of 200 girls, 7-17 years old, was investigated longitudinally 4 times at 1.5-, 1.5- and 5-year intervals. The present study gives information…”
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The effects of an antiprogestin, mifepristone, and an antiestrogen, tamoxifen, on endometrial 17 beta-hydroxysteroid dehydrogenase and progestin and estrogen receptors during the luteal phase of the menstrual cycle: an immunohistochemical study by Mäentausta, O, Svalander, P, Danielsson, K G, Bygdeman, M, Vihko, R

“…The effects of a progesterone antagonist, mifepristone (RU486), and an estrogen antagonist, tamoxifen, given during the early luteal phase on endometrial 17…”
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Immunohistochemical localization of 17 beta-hydroxysteroid dehydrogenase in the human endometrium during the menstrual cycle by Mäentausta, O, Sormunen, R, Isomaa, V, Lehto, V P, Jouppila, P, Vihko, R

“…Immunoaffinity-purified polyclonal anti-rabbit antibody against human placental 17 beta-hydroxysteroid dehydrogenase (17HSD) was used to localize 17HSD in…”
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