Search Results - "Vihko, P T"

Mouse 17 beta-hydroxysteroid dehydrogenase type 2 mRNA is predominantly expressed in hepatocytes and in surface epithelial cells of the gastrointestinal and urinary tracts by Mustonen, MV, Poutanen, MH, Kellokumpu, S, de Launoit, Y, Isomaa, VV, Vihko, RK, Vihko, PT

“…17 beta-Hydroxysteroid dehydrogenase (17HSD) type 2 efficiently catalyzes the conversion of the high activity 17 beta-hydroxy forms of sex steroids into less…”
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Site-directed mutagenesis of the putative active site of human 17 beta-hydroxysteroid dehydrogenase type 1 by Puranen, T J, Poutanen, M H, Peltoketo, H E, Vihko, P T, Vihko, R K

“…Several amino acid residues (Cys54, Tyr155, His210, His213 and His221) at a putative catalytic site of human 17 beta-hydroxysteroid dehydrogenase type 1 were…”
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Site-directed mutagenesis of prostatic acid phosphatase. Catalytically important aspartic acid 258, substrate specificity, and oligomerization by Porvari, K S, Herrala, A M, Kurkela, R M, Taavitsainen, P A, Lindqvist, Y, Schneider, G, Vihko, P T

“…At the active site of rat prostatic acid phosphatase (rPAP), residue Asp258 is a suitable candidate to act as an acid/base catalyst during phosphoester…”
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Expression of transmembrane serine protease TMPRSS2 in mouse and human tissues by Vaarala, Markku H., Porvari, Katja S., Kellokumpu, Sakari, Kyllönen, Atte P., Vihko, Pirkko T.

“…The purpose of this study was to clarify the expression of TMPRSS2 in mice during development and to compare the tissue distribution of the transcripts in…”
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Characterization of Molecular and Catalytic Properties of Intact and Truncated Human 17β-Hydroxysteroid Dehydrogenase Type 2 Enzymes: Intracellular Localization of the Wild-Type Enzyme in the Endoplasmic Reticulum by Puranen, T. J., Kurkela, R. M., Lakkakorpi, J. T., Poutanen, M. H., Itäranta, P. V., Melis, J. P. J., Ghosh, D., Vihko, R. K., Vihko, P. T.

“…Abstract Human 17β-hydroxysteroid dehydrogenase (17HSD) type 2 is a widely distributed enzyme that primarily converts the highly active 17β-hydroxysteroids to…”
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Several genes encoding ribosomal proteins are over‐expressed in prostate‐cancer cell lines: Confirmation of L7a and L37 over‐expression in prostate‐cancer tissue samples by Vaarala, Markku H., Porvari, Katja S., Kyllönen, Atte P., Mustonen, Mika V. J., Lukkarinen, Olavi, Vihko, Pirkko T.

“…A cDNA library specific for mRNA over‐expressed in prostate cancer was generated by subtractive hybridization of transcripts originating from prostatic…”
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Human 17β-hydroxysteroid dehydrogenase type 2 messenger ribonucleic acid expression and localization in term placenta and in endometrium during the menstrual cycle by MUSTONEN, M. V. J, ISOMAA, V. V, VASKIVUO, T, TAPANAINEN, J, POUTANEN, M. H, STENBÄCK, F, VIHKO, R. K, VIHKO, P. T

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Comparison of human prostate specific glandular kallikrein 2 and prostate specific antigen gene expression in prostate with gene amplification and overexpression of prostate specific glandular kallikrein 2 in tumor tissue by Herrala, Annakaisa M., Porvari, Katja S., Kyllönen, Atte P., Vihko, Pirkko T.

“…BACKGROUND There is a need for specific markers that can indicate the different stages of prostate carcinoma. There is ongoing speculation concerning the value…”
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Cloning of mouse 17 β -hydroxysteroid dehydrogenase type 2, and analysing expression of the mRNAs for types 1, 2, 3, 4 and 5 in mouse embryos and adult tissues by MUSTONEN, Mika V. J., POUTANEN, Matti H., ISOMAA, Veli V., VIHKO, Pirkko T., VIHKO, Reijo K.

“…17β-Hydroxysteroid dehydrogenases (17HSDs) are responsible for the conversion of low-activity sex steroids to more potent forms, and vice versa. 17HSD activity…”
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Cloning of mouse 17beta-hydroxysteroid dehydrogenase type 2, and analysing expression of the mRNAs for types 1, 2, 3, 4 and 5 in mouse embryos and adult tissues by Mustonen, M V, Poutanen, M H, Isomaa, V V, Vihko, P T, Vihko, R K

“…17beta-Hydroxysteroid dehydrogenases (17HSDs) are responsible for the conversion of low-activity sex steroids to more potent forms, and vice versa. 17HSD…”
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Several genes encoding ribosomal proteins are over-expressed in prostate-cancer cell lines : Confirmation of L7a and L37 over-expression in prostate-cancer tissue samples by VAARALA, M. H, PORVARI, K. S, KYLLÖNEN, A. P, MUSTONEN, M. V. J, LUKKARINEN, O, VIHKO, P. T

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Prostatic expression of human 5alpha-reductase type 2 during finasteride therapy: a randomized, double-blind, placebo-controlled study by Vaarala, M H, Lukkarinen, O, Marttila, T, Kyllönen, A P, Porvari, K S, Vihko, P T

“…This study was aimed at exploring the effect of finasteride, a non-steroidal competitive inhibitor of the enzyme 5alpha-reductase, on 5alpha-reductase type 2…”
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Characterization of molecular and catalytic properties of intact and truncated human 17beta-hydroxysteroid dehydrogenase type 2 enzymes: intracellular localization of the wild-type enzyme in the endoplasmic reticulum by Puranen, T J, Kurkela, R M, Lakkakorpi, J T, Poutanen, M H, Itäranta, P V, Melis, J P, Ghosh, D, Vihko, R K, Vihko, P T

“…Human 17beta-hydroxysteroid dehydrogenase (17HSD) type 2 is a widely distributed enzyme that primarily converts the highly active 17beta-hydroxysteroids to…”
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Characterization of Molecular and Catalytic Properties of Intact and Truncated Human 17β-Hydroxysteroid Dehydrogenase Type 2 Enzymes: Intracellular Localization of the Wild-Type Enzyme in the Endoplasmic Reticulum1 by Puranen, T. J, Kurkela, R. M, Lakkakorpi, J. T, Poutanen, M. H, Itäranta, P. V, Melis, J. P. J, Ghosh, D, Vihko, R. K, Vihko, P. T

“…Human 17β-hydroxysteroid dehydrogenase (17HSD) type 2 is a widely distributed enzyme that primarily converts the highly active 17β-hydroxysteroids to their…”
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Downregulation of estrogen‐metabolizing 17β‐hydroxysteroid dehydrogenase Type 2 expression correlates inversely with Ki67 proliferation marker in colon‐cancer development by Oduwole, Olayiwola O., Isomaa, Veli V., Nokelainen, Pasi A., Stenbäck, Frej, Vihko, Pirkko T.

“…The 17HSDs are a group of isozymes that catalyze the interconversion between high‐activity 17β‐hydroxysteroids and low‐activity 17‐ketosteroids. In the present…”
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Human 17beta-hydroxysteroid dehydrogenase type 2 messenger ribonucleic acid expression and localization in term placenta and in endometrium during the menstrual cycle by Mustonen, M V, Isomaa, V V, Vaskivuo, T, Tapanainen, J, Poutanen, M H, Stenbäck, F, Vihko, R K, Vihko, P T

“…According to the current hypothesis, 17beta-hydroxysteroid dehydrogenases (17HSDs) regulate the extent of estrogen influence in the endometrium by converting…”
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Sex steroid metabolism in human gastric mucosa: 17 beta-hydroxysteroid dehydrogenase type 2 in normal, inflamed and neoplastic gastric tissues by Oduwole, Olayiwola O, Mäkinen, Johanna M, Isomaa, Veli V, Karttunen, Tuomo J, Vihko, Pirkko T

“…The 17 beta-hydroxysteroid dehydrogenase (17HSD) enzymes are involved in the regulation of the biological activity of sex steroids. We analyzed the expression…”
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Inactivation of prostatic acid phosphatase (PAP), a lipid phosphatase, is a novel cancer mechanism by Vihko, PT, Quintero, I, Ronka, A, Herrala, A, Lindqvist, Y, Porvari, K, Kaija, H, Pulkka, A, Sormunen, R, Soini, Y, Halmekyto, M, Janne, J, Vuoristo, J, Jantti, P, Luokkala, T, Kurkela, R

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Prostatic expression of human 5α-reductase type 2 during finasteride therapy : a randomized, double-blind, placebo-controlled study by VAARALA, Markku H, LUKKARINEN, Olavi, MARTTILA, Timo, KYLLÖNEN, Atte P, PORVARI, Katja S, VIHKO, Pirkko T

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