Search Results - "Vigont, Vladimir A"

Patient-Specific iPSCs-Based Models of Neurodegenerative Diseases: Focus on Aberrant Calcium Signaling by Grekhnev, Dmitriy A, Kaznacheyeva, Elena V, Vigont, Vladimir A

“…The development of cell reprogramming technologies became a breakthrough in the creation of new models of human diseases, including neurodegenerative…”
Get full text

The Mystery of EVP4593: Perspectives of the Quinazoline-Derived Compound in the Treatment of Huntington's Disease and Other Human Pathologies by Grekhnev, Dmitriy A, Kruchinina, Anna A, Vigont, Vladimir A, Kaznacheyeva, Elena V

“…Quinazoline derivatives have various pharmacological activities and are widely used in clinical practice. Here, we reviewed the proposed mechanisms of the…”
Get full text

An Efficient 2D Protocol for Differentiation of iPSCs into Mature Postmitotic Dopaminergic Neurons: Application for Modeling Parkinson's Disease by Lebedeva, Olga S, Sharova, Elena I, Grekhnev, Dmitriy A, Skorodumova, Liubov O, Kopylova, Irina V, Vassina, Ekaterina M, Oshkolova, Arina, Novikova, Iuliia V, Krisanova, Alena V, Olekhnovich, Evgenii I, Vigont, Vladimir A, Kaznacheyeva, Elena V, Bogomazova, Alexandra N, Lagarkova, Maria A

“…About 15% of patients with parkinsonism have a hereditary form of Parkinson's disease (PD). Studies on the early stages of PD pathogenesis are challenging due…”
Get full text

Huntingtin-Associated Protein 1A Regulates Store-Operated Calcium Entry in Medium Spiny Neurons From Transgenic YAC128 Mice, a Model of Huntington's Disease by Czeredys, Magdalena, Vigont, Vladimir A, Boeva, Vasilisa A, Mikoshiba, Katsuhiko, Kaznacheyeva, Elena V, Kuznicki, Jacek

“…Huntington's disease (HD) is a hereditary neurodegenerative disease that is caused by polyglutamine expansion within the huntingtin (HTT) gene. One of the…”
Get full text

STIM2 Mediates Excessive Store-Operated Calcium Entry in Patient-Specific iPSC-Derived Neurons Modeling a Juvenile Form of Huntington's Disease by Vigont, Vladimir A, Grekhnev, Dmitriy A, Lebedeva, Olga S, Gusev, Konstantin O, Volovikov, Egor A, Skopin, Anton Yu, Bogomazova, Alexandra N, Shuvalova, Lilia D, Zubkova, Olga A, Khomyakova, Ekaterina A, Glushankova, Lyubov N, Klyushnikov, Sergey A, Illarioshkin, Sergey N, Lagarkova, Maria A, Kaznacheyeva, Elena V

“…Huntington's disease (HD) is a severe autosomal-dominant neurodegenerative disorder caused by a mutation within a gene, encoding huntingtin protein. Here we…”
Get full text

Comparison of the calcium signaling alterations in GABA-ergic medium spiny neurons produced from iPSCs of different origins by Oshkolova, Arina A., Grekhnev, Dmitriy A., Kruchinina, Anna A., Belikova, Lilia D., Volovikov, Egor A., Lebedeva, Olga S., Bogomazova, Alexandra N., Vigont, Vladimir A., Lagarkova, Maria A., Kaznacheyeva, Elena V.

“…Disease models based on induced pluripotent stem cells (iPSCs) are in high demand because of their physiological adequacy and well-reproducibility of the…”
Get full text

Dithiadiazole derivative 3-(4-nitrophenyl)-5-phenyl-3H-1,2,3,4-dithiadiazole-2-oxide – Novel modulator of store-operated calcium entry by Grekhnev, Dmitriy A., Novikova, Iuliia V., Krisanova, Alena V., Yuskovets, Valeriy N., Chernov, Nikita M., Yakovlev, Igor P., Kaznacheyeva, Elena V., Vigont, Vladimir A.

“…Pathological calcium homeostasis accompanies the development of a large number of different diseases, therefore, the search for new modulators of calcium…”
Get full text

1,2,3,4-dithiadiazole derivatives as a novel class of calcium signaling modulators by Novikova, Iuliia V, Grekhnev, Dmitriy A, Oshkolova, Arina, Nomerovskaya, Maria A, Kolesnikov, Dmitrii O, Krisanova, Alena V, Yuskovets, Valeriy N, Chernov, Nikita M, Yakovlev, Igor P, Kaznacheyeva, Elena V, Vigont, Vladimir A

“…Aberrant calcium signaling is associated with a diverse range of pathologies, including cardiovascular and neurodegenerative diseases, diabetes, cancer, etc……”
Get full text

Manifestation of Huntington's disease pathology in human induced pluripotent stem cell-derived neurons by Nekrasov, Evgeny D, Vigont, Vladimir A, Klyushnikov, Sergey A, Lebedeva, Olga S, Vassina, Ekaterina M, Bogomazova, Alexandra N, Chestkov, Ilya V, Semashko, Tatiana A, Kiseleva, Elena, Suldina, Lyubov A, Bobrovsky, Pavel A, Zimina, Olga A, Ryazantseva, Maria A, Skopin, Anton Yu, Illarioshkin, Sergey N, Kaznacheyeva, Elena V, Lagarkova, Maria A, Kiselev, Sergey L

“…Huntington's disease (HD) is an incurable hereditary neurodegenerative disorder, which manifests itself as a loss of GABAergic medium spiny (GABA MS) neurons…”
Get full text